Cancer could return unless stored ovarian tissue undergoes adequate testing before re-im...(Jehoshua Dor) carried out the research w...),Health

Date:4/21/2008

Jehoshua Dor), carried out the research with Professor Dina Ben Yehuda, director of the Hematology Division at Hadassah University Hospital, Jerusalem. Dr Meirow said that fertility centres with close connections to cancer and haematological centres should be able to work together in order to adopt the correct methods for checking stored tissue.

Before collecting tissue from the 58 young women in this study, Dr Meirow and his colleagues used various imaging methods (sonography, CT and PET scans) to look for cancer in the pelvis and ovaries of the patients; the women were about to receive chemotherapy for haematological cancers such as Hodgkins lymphoma, non-Hodgkins lymphoma and leukaemia, between 1997 and 2007. They found cancer in the pelvic area of two patients, and therefore ovarian tissue was not harvested. They collected tissue from the other 56 patients and, in addition to freezing strips for future transplantation; they also froze a smaller piece of ovarian tissue separately for each patient. They planned to use these extra strips for future checks for the presence of cancer cells, using the most modern methods that would be available at the time the tissue was thawed and prepared for transplantation.

When the ovarian tissue was thawed, they used several different methods to detect minimal residual disease:

• Histological evaluation (close examination of thin strips of tissue)
• Immunohistochemical staining (using antibodies to detect abnormal cells)
• PCR (polymerase chain reaction, which amplifies sections of DNA) and real-time PCR to detect molecular markers that would indicate the presence of cancer cells.

The results were compared with the same tests carried out on the patients diseased tissue to check that the tests were capable of detecting cancer when it was known to be present.

None of the tests detected minimal residual disease in ovarian tissue for any of the patients, wi
'/>"/>

Contact: Emma Mason wordmason@mac.com 07-711-296-986 European Society for Human Reproduction and Embryology Source:Eurekalert

0 GOOD

Page: 1 2 3
Related medicine news :

1. Cancer cells spread by releasing bubbles, according to an MUHC study
2. Thousands of volunteers needed to help bring cure for cancer closer
3. Many Cancer Survivors Are Overweight and Sedentary: Study
4. Study reveals inaccuracies in studies of cancer treatment
5. Cancer survivors have low levels of physical activity and high levels of obesity
6. Obesity, inactivity as common among cancer survivors as rest of Canadians, study shows
7. Exercise Combats Cancer Fatigue
8. Dealing Cervical Cancer a Knockout Blow
9. Talk Therapy Proves Effective for Terminal Cancer Patients
10. Vitamin D and breast cancer risk
11. Study finds patients overestimate cancer screening history