Navigation Links
Cancer cells show rewired, fragmented microRNA networks
Date:5/3/2010

COLUMBUS, Ohio A new study shows that a family of molecules called microRNA work together in single, well-connected networks to control many important functions in healthy cells, but that in cancer cells the networks are rewired and fragmented.

The research, led by scientists at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in collaboration with investigators at 11 other centers, introduces a new way of discovering cancer genes and identifies new miRNAs that can be used as targets for drug development and pinpoints possible new cancer-related proteins, says study leader Dr. Carlo Croce, professor of molecular virology, immunology and medical genetics, and director of Ohio State's Human Cancer Genetics program.

MicroRNA (miRNA) are tiny molecules discovered 10 years ago that control important cell functions, including growth, proliferation and differentiation. Abnormal miRNA activity plays an important role in cancer development.

The new study, published in the May 3 issue of the journal Genome Research, shows that the miRNA network in healthy cells, when mapped, resembles a family tree with dozens to hundreds of members. Each cell type has its own specific network, with particular miRNAs playing a more central role and serving as hubs within the network.

In cancer cells, however, the single network is replaced by subnetworks that usually include small detached clusters of two to six miRNAs.

"The presence of these small groups that exist outside the main network was completely unexpected," Croce says. "Some of these miRNA outliers are well known cancer genes, while the involvement of others in cancer was unknown."

Previous studies have measured differences in individual miRNA levels between cancer and normal tissues, says first author Stefano Volinia, assistant professor of biomedical informatics and of molecular virology,
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... safe and sound is one of the best Halloween treats ... and goody bags have reflective strips that improve visibility to ... Meadowlands Hospital Medical Center in Secaucus, N.J. Trick-or-treaters ... Davis said. He offers these others tips: ... small area of skin first to ensure it doesn,t cause ...
(Date:10/25/2014)... WI (PRWEB) October 25, 2014 ... tax-advantaged medical and other benefits account management services, ... to help employers save on taxes, reduce administrative ... Suites provide tax savings and the efficient handling ... pick the Suite that best meets their goals ...
(Date:10/25/2014)... QueenBeeTickets.com has a variety of tickets for ... prices. Bob Seger & The Silver Bullet Band tickets ... are going on sale October 25 and are expected ... browse the selection of tickets for Bob Seger & ... singer is touring North America beginning next month, and ...
(Date:10/25/2014)... Mesothelioma researchers are reporting extended survival in a ... his combination drug therapy became too toxic. Click ... on the Surviving Mesothelioma website. , A new ... suggests that “maintenance therapy” with pemetrexed may be the ... higher doses of cisplatin. , “Although the standard ...
(Date:10/25/2014)... Steven Reinberg HealthDay Reporter ... causes common cold sores -- herpes simplex -- might increase ... suggest. In fact, being a carrier of certain antibodies ... the researchers found. "The identification of a treatable ... a breakthrough," said lead researcher Dr. Hugo Lovheim, an associate ...
Breaking Medicine News(10 mins):Health News:Tips for Safe Trick-or-Treating 2Health News:TASC’s New Suites Offer Tax Savings and Protection 2Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3
... central government is supporting a programme named the "golden ... validate medicine protocols //for the global market.These are the ... of Medical Research and the Department of Indian System ... that the market for plant medicines would be worth ...
... Fibrosis is a rare genetic disorder, usually diagnosed in ... mucus to become thick, dry and sticky. //The mucus ... and other organs in the body. ,There ... disease varies from person to person and generally focuses ...
... afflicting the older population its possible to drive safely ... ,According to the latest edition of Harvard Men's Health ... increase the risk for auto accidents. Even normal, healthy ... reaction time, and sensory abilities. But simple preparations and ...
... Research by the scientists from Johns Hopkins had found that ... are the ones who follow all the advice of their ... ,In a national survey of more than 5,000 Americans, those ... medical encounter were more likely to report higher levels of ...
... The problem of child obesity is severe like never before. ... believe as a study from Tufts University this month proves, ... prologue. // ,''It's quite astounding -- this shows ... Boston Medical Center nutrition specialist involved with the initiative that ...
... the incidence of breast cancer is rapidly increasing in urban ... number one cancer in our major metros according to a ... ,The number of breast cancer cases is estimated to have ... marriage and delayed motherhood are some factors that can lead ...
Cached Medicine News:Health News:Early Awareness About Weight Management Needed To Tackle Lifelong Obesity 2
(Date:10/22/2014)... IRVINE, Calif. , Oct 22, 2014 ... Irvine, California , announced the receipt ... Small Business Innovation Research award (SBIR) from the National Institute of ... will fund the development of a Pan-HIV Protein Microarray ... the HIV-1 and HIV-2 subtypes and aid in the ...
(Date:10/22/2014)... , Oct. 22, 2014 Moms are ... health trackers for themselves and their kids, according to ... Report: Health & Fitness Go Mobile for Moms, the ... Series. BabyCenter, the number 1 pregnancy and parenting web ... that 55 percent of moms surveyed say they can,t ...
(Date:10/22/2014)... PORTLAND, Oregon , October 22, 2014 ... titled, "Global Disposable Gloves Market (Product type, Form, End ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... the global disposable gloves market. Based on key trends ... to be valued at $7.9 billion by 2020, registering ...
Breaking Medicine Technology:Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
Latex agglutination slide test for the qualitative and semi-quantitative in vitro determination of Rheumatoid Factor in serum....
For the quantitative in vitro determination of Carbon Dioxide in serum and plasma....
For the quantitative in vitro determination of Uric Acid in serum, plasma and urine...
The BUN method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of urea nitrogen in serum, plasma and urine....
Medicine Products: