Navigation Links
Cancer cell survival is not 'miR-ly' dependent on p53
Date:1/10/2011

Squamous cell carcinoma (SCC) is a common type of skin cancer. In this paper, Leif Ellisen and colleagues at Mass General Hospital investigated the p53-related proteins p63 and p73 in SCC cells, and discovered a feedback loop between p63, microRNAs (miRs), and p73. In a model of SCC, they found that inhibiting one of these miRs decreased tumor growth and made the cells more sensitive to chemotherapy, highlighting a new potential therapeutic target.

Squamous cell carcinoma (SCC) is a common type of skin cancer and remains one of the most resistant to available chemotherapies. Many cancer therapeutic strategies are directed at restoring the function of the tumor suppressor gene p53, because when active, cells are more sensitive to the DNA damage induced by chemotherapy. Other proteins related to p53, including p63 and p73, have also been implicated in cancer and cell sensitivity to chemotherapy. Both p63 and p73 are overexpressed in SCC, and are thought to play a role in chemoresistance. In new research, Leif Ellisen and colleagues at Mass General Hospital in Boston investigated the relationship between p63 and p73 in human and mouse SCC cells. They found that p63 negatively regulates the expression of a number of microRNAs (miRs), and that some of these miRs target p73 for inhibition. One of these, dubbed miR-193a, was also positively regulated by p73, suggesting a feedback loop that might promote chemoresistance in these cells. In a mouse model of SCC, the researchers found that inhibiting miR-193a decreased tumor growth and made the cells more sensitive to the chemotherapeutic agent cisplatin. The researchers believe that these findings identify a pro-survival mechanism in SCC, and may highlight new therapeutic targets in the fight against cancer.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Geography May Influence Colon Cancer Screening Rates
2. For non-whites, geography plays key role in colon cancer screening
3. Race affects regional colorectal cancer screening disparities
4. Quality of life measures in breast cancer clinical trials
5. Quality of Life Key Measure in Breast Cancer Clinical Trials
6. Breast Cancer Outcome: Your Doctor Matters
7. VIB-K.U. Leuven scientists clear the way to alternative anti-angiogenic cancer therapy
8. TGen drug development teams with Oncoholdings to fight cancer
9. High dietary fat, cholesterol linked to increased risk of breast cancer
10. Cancer in a single catastrophe
11. Steering cancer inflammation to inhibit tumor growth and spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2017)... ... , ... "Photo Cloud allows FCPX users to add favorited photos to any ... said Christina Austin - CEO of Pixel Film Studios. , To begin, select ... Presets include scenes with one, three, four or five focus points. There are five ...
(Date:1/21/2017)... ... ... Caronlab Australia, an Australian company known for health and beauty products such ... where it benefited from outstanding meetings with major retail buyers. , Caron Labs has ... this trade show, the company had the chance to demonstrate its products and provide ...
(Date:1/21/2017)... ... ... perfect set of tools for video editors that want to create the illusion of rack ... of Pixel Film Studios. , Video editors using ProDOF can add realistic depth of ... from one area into the next. ProDOF comes with 0.5 second, 1.0 second, 1.5 ...
(Date:1/21/2017)... ... January 21, 2017 , ... Phytocéane invites you to ... the rest of the world with ZANZIBAR SHOWER GEL. Inspired by the beauty of ... Virgin Coconut Oil and moisturizing vegetal coral to create this gentle, crystal-clear shower gel ...
(Date:1/21/2017)... Rosa, CA (PRWEB) , ... January 21, 2017 ... ... announce that Redwood Family Dermatology has recently joined their multi-specialty medical ... a full range of cosmetic services. , “We’re excited to add this excellent ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... The American Pharmacists Association (APhA) is excited ... Medically Underserved Areas Enhancement Act (H.R. 592) ... was previously introduced in the 114 th session ... through pharmacists and their patient care services. ... (R-KY), G.K. Butterfield (D-NC), Tom ...
(Date:1/23/2017)... ALBANY, New York , January 23, 2017 ... Non-Invasive Prenatal Testing Market was valued at US$0.53 bn ... by expanding at a strong 17.50% CAGR between 2014 and 2022. ... - Global Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ... ...
(Date:1/23/2017)... PALMA, Spain , January 23, ... a clinical-stage biopharmaceutical company focused on treatments for ... has been enrolled in the Phase IIb "CaLIPSO ... the treatment of cardiovascular calcification (CVC) in end-stage-renal-disease ... ESRD patients, in the last stage of chronic ...
Breaking Medicine Technology: