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Cancer cell line developed that is resistant to new cancer therapy
Date:12/11/2007

hanisms of resistance and an in vivo model, a mouse model typically, to test new combinations you design based on studies in culture, says Dr. Bhalla.

The researchers have put the cell line into a mouse model and other scientists already are asking for the resistant cell line, he says.

This particular cell line can be used to really look at newer agents and new combinations in vitro and in vivo and see if they are safe and effective together, Dr. Fiskus says.

Heat shock proteins are protein caretakers, activating genes that ultimately make proteins, move them around cells and fold them into shape for proper function. Misfolded proteins can cause cancer.

MCG is participating in an early-phase clinical trial of the oral HDAC inhibitor, LBH589, developed by Novartis Corp. Studies also are underway for some innovative uses of hsp90 inhibitors, including Dr. John Catravas studies of its potential as an anti-angiogenesis agent and Dr. Abdullah Kutlars studies to see if it can reduce morbidity and related lung problems in sickle cell disease by suppressing inflammation.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia  
Source:Eurekalert

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