Navigation Links
Cancer cell line developed that is resistant to new cancer therapy
Date:12/11/2007

A cancer cell line that is resistant to one of the newest classes of cancer treatments has been developed by researchers who already are using it to determine what else to give patients when this happens.

The ultimate goal is to be able to understand how cancer cells develop resistance and to have forward-thinking strategies about how to combat that resistance, says Dr. Warren Fiskus, postdoctoral fellow in the laboratory of Dr. Kapil Bhalla, director of the Medical College of Georgia Cancer Center.

Resistant cells emerged by treating human leukemic cells with regular, increasing doses of histone deacetylase, or HDAC, inhibitors, similar to what patients would receive. At each dose level, there were some cells that did die, says Dr. Fiskus. Ultimately, we isolated a population of cells that were resistant to very high concentrations of these agents and other agents in the same class.

Dr. Fiskus is presenting the findings Dec. 11 during the American Society of Hematologys 49th Annual Meeting and Exposition in Atlanta.

They found the HDAC inhibitor-resistant cell line resistant to many therapies, including more standard treatment such as chemotherapy, but highly sensitive to heat shock protein 90, or hsp90, inhibitors, another emerging cancer treatment.

As part of their resistance mechanisms, they acquired greater sensitivity to hsp90 inhibitors, says Dr. Bhalla, Cecil F. Whitaker Jr., M.D./Georgia Research Alliance Eminent Scholar in Cancer. This creates a potential combination that can be tested in mouse models and ultimately clinical trials.

HDAC and hsp90 inhibitors are both being studied in combination with other cancer therapies but not each other. However the MCG researchers, who already have published work indicating a synergistic effect, were not surprised by what they found.

Resistance to HDAC inhibitors is going to emerge, so you need a cellular model to understand mechanisms of resistance and an in vivo model, a mouse model typically, to test new combinations you design based on studies in culture, says Dr. Bhalla.

The researchers have put the cell line into a mouse model and other scientists already are asking for the resistant cell line, he says.

This particular cell line can be used to really look at newer agents and new combinations in vitro and in vivo and see if they are safe and effective together, Dr. Fiskus says.

Heat shock proteins are protein caretakers, activating genes that ultimately make proteins, move them around cells and fold them into shape for proper function. Misfolded proteins can cause cancer.

MCG is participating in an early-phase clinical trial of the oral HDAC inhibitor, LBH589, developed by Novartis Corp. Studies also are underway for some innovative uses of hsp90 inhibitors, including Dr. John Catravas studies of its potential as an anti-angiogenesis agent and Dr. Abdullah Kutlars studies to see if it can reduce morbidity and related lung problems in sickle cell disease by suppressing inflammation.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia  
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer cell line developed that is resistant to new cancer therapy
(Date:5/28/2017)... ... May 28, 2017 , ... ... proud to announce that Sheldon K. Cho, MD, has joined its Winter Haven ... specialty that concentrates on minimally invasive techniques to treat and manage many types ...
(Date:5/27/2017)... ... May 26, 2017 , ... A May 8 article ... doctor for colds or respiratory issues that are not responsive to antibiotics nevertheless obtain ... doctors may be largely responsible for the problem both in Canada and the United ...
(Date:5/27/2017)... ... May 27, 2017 , ... In any business, follow up is ... of your dental team at presenting treatment, there will always be some patients who ... time and money on best practices when it comes to presenting treatment. After ...
(Date:5/27/2017)... ... , ... Most us are familiar with the sound of occasional popping joints ... Initiative shows that certain people who experience consistent joint popping, grating and grinding ... the opportunity to treat patients before the problem becomes pronounced, potentially hedging off more ...
(Date:5/26/2017)... ... May 26, 2017 , ... The American Parkinson ... more than eighty-nine grant submissions all vying for nearly $1,000,000 in funding that ... field.     , The American Parkinson Disease Association (APDA) is focused on advancing scientific ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... PORTLAND, Ore. , May 9, 2017 /PRNewswire/ ... company that provides technology solutions to improve the ... reported financial results for the first quarter ended ... that our products enable our customers to identify ... them to intervene before events like heart attacks ...
(Date:5/8/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO)., has completed its acquisition ... care service center company based in Chantilly, ... management programs for leading pharmaceutical manufacturers and health care ... will join Envoy Health Management, LLC , as ... firms, and other service companies. Together, WRB and EnvoyHealth ...
(Date:5/6/2017)... is Stroke Awareness Month and Omron Healthcare is reminding ... prevent a stroke: monitor and manage your blood pressure. ... undetected and uncontrolled hypertension is a leading risk factor ... personal heart health technology, recently evolved its mission to ... and is advancing a national public education effort to ...
Breaking Medicine Technology: