Navigation Links
Cancer-causing virus associated with higher risk of new HIV infection
Date:4/30/2009

Infection with anal human papillomavirus (HPV), a virus that can cause anal and cervical cancers, is associated with a higher risk of new HIV infection in previously HIV-negative men who have sex with men (MSM), according to new UCSF research.

Reported online ahead of print in the journal AIDS, the findings are available now. They are scheduled for publication in an upcoming print issue.

In previous studies, other sexually transmitted infections have been associated with higher risk of HIV infection and HPV is the most common sexually transmitted infection.

"We looked at HIV-negative men who have sex with men who were at high risk for HIV infection and who had multiple risk factors. Our results showed a strong independent association for increased risk of HIV acquisition among those men who were already infected with anal HPV," said the study's lead investigator, Peter V. Chin-Hong, MD, associate professor of clinical medicine and director of the program in transplant and immunocompromised host infectious diseases at UCSF.

The 1400 study participants were part of the EXPLORE trial, a large clinical trial to test the efficacy of a behavioral intervention for HIV-negative MSM with sites in Boston, Denver, New York and San Francisco. Risk factors were calculated from those men who became HIV-infected over the course of the trial and infections were identified by blood tests.

"We think that HPV enhances susceptibility to HIV infection through two mechanisms. Anatomically, the virus causes anal lesions. These lesions bring blood vessels closer to the surface and also the lesions' skin layer is thinner and more easily shredded, which frequently causes bleeding. These disruptions of the mucosal barrier could allow easier entry for HIV," said Chin-Hong.

In addition, HPV activates the immune system. The inflammatory cells recruited to the HPV lesionsdendritic cells, macrophages and CD4 T cellsare the immune cells most susceptible to HIV infection.

HPV vaccine has been found effective in preventing acquisition of the virus by women. Clinical trials testing the effectiveness of the vaccine among MSM are currently under way.

"To date, the focus of attention on HPV has been almost exclusively on its key role in causing squamous cell cancer. This study points to another important means by which HPV infection may be associated with morbidity and mortality, i.e., through potentiation of HIV infection. A direct role for HPV in this process will need to be confirmed in additional studies, and additional studies will be needed to understand the mechanisms by which HPV may do this, said the study's senior investigator and author, Joel Palefsky, MD, professor of medicine and director of the Anal Neoplasia Clinic at UCSF.

"But it is encouraging to note that to the degree that HPV truly plays a role in increasing the risk of acquiring HPV infection, primary prevention of HPV infection through HPV vaccination may potentially reduce that risk," he added.


'/>"/>

Contact: Jeff Sheehy
jsheehy@ari.ucsf.edu
415-597-8165
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. Cancer-Causing Toxins Detected in Fluoride Chemicals, Says NYS Coalition Opposed to Fluoridation
2. URI scientists reveal mechanism that regulates cancer-causing gene
3. Cancer-Causing Gene Discovery Suggests New Therapies
4. K-State Researcher Finds That the 1918 Spanish Flu Virus Can Infect Swine and Resulted in Current Lineage of H1N1 Swine Influenza Viruses
5. Aethlon Medical Confirms Hemopurifier(R) Is a Treatment Candidate Against Swine Flu Virus
6. DxNA to Use its Rapid Detection Platform to Simplify Testing for Swine Flu (H1N1 Virus)
7. Skinvisibles DermSafe(R) Hand Sanitizer Kills Swine Flu Virus
8. Grupo Aeroportuario del Pacifico, S.A.B. de C.V. Announcement Regarding Swine Flu Virus
9. Pelosi Statement on Swine Flu Virus
10. Copan Diagnostics, Inc. Offers Kit for Rapid Collection of Nasopharyngeal Sample to Detect Swine Flu Virus
11. Harmless Virus May Be Deadly to Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... The Rett Syndrome Research Trust ... disorder that afflicts 350,000 individuals worldwide. Rett Syndrome is caused by alterations ... strikes females. Following a normal infancy, Rett Syndrome takes effect in toddlerhood ...
(Date:3/22/2017)... ... , ... Last year, 43 million gallons of surplus milk was reportedly dumped ... excess dairy can be caused by several factors, one pharmaceutical company CEO suggests high ... digest lactose, a sugar found in milk and milk products. It is ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... planning, and related services to communities across eastern Texas, is announcing a charity ... providing meals to hungry children and adults. , Consistently a top-rated nonprofit ...
(Date:3/22/2017)... ... March 22, 2017 , ... Martin J. Mitchell Insurance, ... to communities throughout central Ohio, is initiating a charity drive to raise support ... of Defense and the Veteran's Brain Injury Center conclude that more than one ...
(Date:3/22/2017)... ... ... NYC Chiropractor Dr. Steven Shoshany recently helped host a seminar at his cutting ... and focused on a new protocol for treating pain. Dr. Shoshany is among the ... furthermore the first seminar in the country was hosted at his Integrated Chiropractic Practice. ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... ENGLEWOOD, Colo. , March 22, 2017 /PRNewswire/ ... leader in the development of Ampion™, a low ... anti-inflammatory properties, today announced that it is re-issuing its ... 2017 to incorporate certain disclosures that are required ... and 610(b). Included below are these additional disclosures along ...
(Date:3/22/2017)... Inc. today announced the appointment of Martyn Coombs as ... of ImaginAb, said "At ImaginAb we have exciting science and technology. ... our business, particularly in commercializing and making step changes in the ... realize our potential." ... Mr. Coombs is a recognized industry leader in nuclear medicine and ...
(Date:3/22/2017)... 22. März 2017   VWR ... tätige Anbieter von Produkten und Dienstleistungen für ... von EPL Archives Inc. bekannt, eines internationalen ... im kompletten Zyklus regulierter Forschung, Entwicklung und ... Speicherung von Dokumenten und Zusatzdienstleistungen zur Seite ...
Breaking Medicine Technology: