Navigation Links
Cancer categories recast in largest-ever genomic study
Date:8/7/2014

New research partly led by UC San Francisco-affiliated scientists suggests that one in 10 cancer patients would be more accurately diagnosed if their tumors were defined by cellular and molecular criteria rather than by the tissues in which they originated, and that this information, in turn, could lead to more appropriate treatments.

In the largest study of its kind to date, scientists analyzed molecular and genetic characteristics of more than 3,500 tumor samples of 12 different cancer types using multiple genomic technology platforms.

Cancers traditionally have been categorized by their "tissue of origin"such as breast, bladder, or kidney cancer. But tissues are composed of different types of cells, and the new work indicates that in many cases the type of cell affected by cancer may be a more useful guide to treatment than the tissue in which a tumor originates.

The study, published August 7, 2014 in the online edition of Cell, was conducted as part of The Cancer Genome Atlas (TCGA) initiative spearheaded by the National Cancer Institute and National Human Genome Research Institute, both part of the National Institutes of Health.

In the new work, TCGA Research Network scientists analyzed DNA, RNA, and protein from 12 tumor types using six different genomic technologies to see how different tumor types compare to one another. The team arrived at a classification based on 12 cancer subtypes. Five of these matched up well with tissue-of-origin classifications, but several newly identified subtypes were seen to affect a variety of tissues.

"This genomic study not only challenges our existing system of classifying cancers based on tissue type, but also provides a massive new data resource for further exploration, as well as a comprehensive list of the molecular features distinguishing each of the newly described cancer classes," said co-senior author Christopher Benz, MD, professor at the Buck Institute for
'/>"/>

Contact: Peter Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists uncover key piece to cancer cell survival puzzle
2. Largest cancer genetic analysis reveals new way of classifying cancer
3. Gut Bacteria May Reveal Colon Cancer, Study Finds
4. New Cancer Classification System Might Boost Patient Outcomes
5. Cell mechanics may hold key to how cancer spreads and recurs
6. Sharp Rise in Risk With New Breast Cancer Gene, Scientists Say
7. NuvOx Pharma Begins Clinical Trial to Treat Brain Cancer
8. Gut microbiome analysis improved noninvasive colorectal cancer screening
9. Young Cancer Patients at Loma Linda University Children's Hospital Treated to an Afternoon of Fun with UCLA Football Players, Sponsored by Stater Bros
10. Gene increases risk of breast cancer to 1 in 3 by age 70
11. Daily Aspirin May Help Prevent Cancer, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Dr. Vu Ho, a Dallas based facial plastic ... med-spa with the addition of new Silk Peel skin ... and services. , “Silk Peel is a procedure that ... “As a result it can address issues like acne ... or blemishes.” , Similar to microdermabrasion, Silk Peel ...
(Date:12/24/2014)... Mike Billings , PT, MS, CEEAA, President ... PT, MBA, GCS, Director of Professional Development to discuss ... of the Improving Medicare Post-Acute Care Transformation Act ... the Infinicast, the two leaders discuss how the IMPACT ... to standardize post-acute assessment data for quality, payment, and ...
(Date:12/24/2014)... (HealthDay News) -- A new, injectable weight-loss drug has ... The agency on Tuesday approved Saxenda (liraglutide) for ... overweight and have at least one weight-related health condition, ... high cholesterol. Patients taking the drug, made by ... exercise regularly, the FDA noted. "Obesity is a ...
(Date:12/24/2014)... Steven Reinberg HealthDay ... New guidelines from the American Diabetes Association (ADA) call for ... with diabetes to help prevent heart disease. These new ... of Cardiology and American Heart Association, which also recommend giving ... heart disease, including people with diabetes. "We agree that ...
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 24, 2014 ... COC Industry is a professional and in-depth research ... the report introduces COC basic information, including its ... policy analysis, news analysis, etc. This report also ... structure etc. Production is separated by regions, technology ...
Breaking Medicine News(10 mins):Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Latest Episode of Infinicast Features Infinity Rehab President Discussing IMPACT Act of 2014 and Changes for Post-Acute Therapy Providers in 2015 2Health News:FDA Approves New Weight-Loss Drug 2Health News:FDA Approves New Weight-Loss Drug 3Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 2Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 3Health News:COC/ Cyclic Olefin Copolymer Market: Global 2015-2020 Forecasts & Research Report Now at DeepResearchReports.com 2Health News:COC/ Cyclic Olefin Copolymer Market: Global 2015-2020 Forecasts & Research Report Now at DeepResearchReports.com 3
... At the 54th Annual Meeting of SNM, the ... medicine professionals, German researchers stated that early ... identifies patients responding to chemotherapy for esophageal cancer. ... apply PET results from early metabolic response assessment ...
... Secretary Mike Leavitt announced today that HHS has awarded a ... Denmark to manufacture and deliver 20 million doses of ... ,The vaccine would be recommended in the event of ... who have weakened immune systems. The full supply of the ...
... Center for Consumer Freedom (CCF) welcomed a new study ... & Adolescent Medicine, which will contribute to the steadily ... television food advertising and childhood obesity. A report issued ... similar results. ,The Archives study found that ...
... Pharmion Corporation today released interim findings from its ... company's third-generation synthetic anthracycline currently in development ... ,These findings indicate favorable interim results ... comparing Amrubicin to the current treatment standard, topotecan, ...
... by researchers at the Duke University Medical Center has found ... 3-fatty acids and fiber-related compounds known as lignans, is ... also think that the seed, which is similar to a ... events that leads cells to divide irregularly and become cancerous. ...
... why some people get anxious, or really scared when faced ... Well researchers at the European Molecular Biology Laboratory (EMBL) ... a new research they conducted on mice. ,They ... that could be potentially dangerous but not necessarily so, as ...
Cached Medicine News:Health News:Esophageal Cancer Patients' Positive Responses to Chemotherapy Accurately Identified by PET 2Health News:HHS Buys Next Generation Smallpox Vaccine 2Health News:HHS Buys Next Generation Smallpox Vaccine 3Health News:New Studies: Commercials Aren't Making Kids Fat 2Health News:Amrubicin Shows Encouraging Results for Small Cell Lung Cancer Treatment 2Health News:Flaxseed Helps in Reducing the Risk of Prostate Tumor Spread 2Health News:Researchers Have Found Clue to How Fear Changes into Phobia 2
(Date:12/24/2014)... /PRNewswire/  -- Tianyin Pharmaceutical Inc. (NYSE Amex: ... in the patented biopharmaceutical, modernized traditional Chinese medicine ... released unaudited preliminary financial results for the first ... Year 2015 Ended September 30, 2014 Financial Highlights: ... $14.7 million in 1Q14 with gross margins improved ...
(Date:12/24/2014)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ), ... announce Jennifer Hagerman , Pharm.D., AE-C, senior director ... as the president of the Michigan Pharmacists Association on ... place Feb. 28, 2015, at the MPA Annual Convention ... Center in Detroit, Michigan . Hagerman ...
(Date:12/24/2014)... KENNEWICK, Wash. , Dec. 23, 2014 /PRNewswire/ ... stage development company engaged primarily in the development ... and therapeutic applications, today announced that it has ... the Food and Drug Administration ("FDA") for marketing ... to Section 513(f)(2) of the U.S. Food, Drug ...
Breaking Medicine Technology:TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
... Solutions, Inc. (NYSE: MHS ) announced today ... principal amount of 2.750% senior notes due September 15, ... senior notes due September 15, 2020 in an underwritten ... & Co. are acting as representatives of the several ...
... Inc. (Nasdaq: CADX ), a biopharmaceutical ... product candidates principally for use in the hospital ... a corporate overview at the following investment conferences: ... Global Healthcare ConferenceDate:  Tuesday, September 14, 2010 Time: ...
Cached Medicine Technology:Medco Issues $1.0 Billion of Senior Notes 2Medco Issues $1.0 Billion of Senior Notes 3Cadence Pharmaceuticals to Present at Four Investment Conferences During the Month of September 2010 2