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Cancer bound
Date:11/2/2012

errupting unregulated replication. However, the cell's own NER machinery can combat the drug by removing it and repairing the genome, just as in healthy non-cancerous cells.

"One direction in drug design is to find pharmaceuticals that still inhibit replication but that are less susceptible to NER," Broyde said. "Understanding the mechanism of NER will be valuable in designing the next generation of chemotherapeutic agents. These would be more effective if they were more resistant to NER."


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Contact: Aaron Dubrow
aarondubrow@tacc.utexas.edu
512-475-9439
University of Texas at Austin, Texas Advanced Computing Center
Source:Eurekalert  

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