Navigation Links
Cancer bound
Date:11/2/2012

as. When it finds one, it slips a structure called a beta-hairpin between the strands, marking the DNA for NER. But if a lesion makes DNA more stable, the strands become more difficult to separate and the beta hairpin can't signal for repair.

How can molecules as large and disruptive as a PAH stabilize DNA in the first place?

"If you remember from chemistry, every kind of molecule interacts with other molecules through so-called Van der Waals interactions," said Nicholas Geacintov, a chemistry professor at NYU. "The DNA and the carcinogen bound to it also have the same kind of interactions," he said, specifically referring to the PAH-derived lesions that intercalate, or wedge themselves, between DNA base pairs.

The role of Van der Waals forces, which Broyde calls "stacking interactions" for these systems, was made clear through a series of computer simulations performed, analyzed, interpreted and visualized by Yuqin Cai, a post-doctoral senior research scientist in Broyde's lab. "The computer simulations revealed the structural, energetic and dynamic properties of the DNA containing the PAH-derived lesions, " said Broyde, who specializes in providing a mechanistic understanding of complex biological processes using molecular dynamics simulations and other front-line computational approaches.

"You can make movies of the dynamic trajectory which allow you to see the real mobility of the entire system," Broyde said. "You can watch the DNA flexing and the backbone moving dynamically and the carcinogen moving in and out. It's not rigid you can see its aliveness."

Broyde and her team's simulations revealed that of the six different lesions examined (three chemicals with two different geometric configurations each), those caused by dibenzo[a,l]pyrene, the most tumorigenic PAH investigated, were the most resistant to repair. The five-ringed structure of the carcinogen provided ample stacking opportunities, which stabilized the D
'/>"/>

Contact: Aaron Dubrow
aarondubrow@tacc.utexas.edu
512-475-9439
University of Texas at Austin, Texas Advanced Computing Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. New finding gives clues for overcoming tamoxifen-resistant breast cancer
2. Combination treatment may improve survival of breast cancer patients with brain metastases
3. UC Davis scientists identify new target for lung cancer treatment
4. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
5. George Mason University researchers target breast cancer in 3 trials
6. Orange County partnership to target cancer health disparities
7. Laser-light testing of breast tumor fiber patterns helps show whose cancer is spreading
8. Male fertility can be restored after cancer treatment, says Pitt team
9. Stem cells show promise for treating infertility in cancer patients
10. Cancer Drug Reduced Relapses in MS Patients: Studies
11. Study: Repeated surgeries appear to extend life of patients with deadliest of brain cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer bound
(Date:7/12/2014)... SATURDAY, July 12, 2014 (HealthDay News) -- If you make ... contends. In one experiment, 56 adults were led on ... an exercise walk or a scenic walk. The participants were ... it was an exercise outing ate 35 percent more chocolate ... a scenic walk. In another experiment, 46 adults were ...
(Date:7/12/2014)... PA (PRWEB) July 12, 2014 Using ... so one of two inventors from Ashland, Va., decided ... do this. "This inspired us to conceive of our ... of the patent-pending KIDNEY KOVER, which provides an inconspicuous ... It avoids embarrassment, as well as promotes comfort and ...
(Date:7/12/2014)... 2014 “Critical Care Therapeutics in ... Late-Stage Four-Factor PCCs and Recombinant Products to Drive ... care market in the US, UK, France, Germany, ... an estimation of market size for 2013, along ... care indications that are being treated using the ...
(Date:7/12/2014)... article released by Seattle's well known plastic surgeon, Dr. Bryan ... cosmetic surgical procedures in summer months . , As ... enliven the rainy Pacific Northwest, many people are turning their ... out as much during the winter as they had planned. ... eager to look their best for their summer vacations, and ...
(Date:7/12/2014)... West Palm Beach, FL (PRWEB) July 12, 2014 ... wide variety of high-quality peptides that are used solely ... online. To honor two successful years in business, Maxim ... Performance LLC, has just launched a new and updated ... addition, the research blog section has been updated with ...
Breaking Medicine News(10 mins):Health News:Make Exercise Fun, Eat Less Afterwards 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2
... Macmillan Cancer Support of UK has taken a strong campaign ... that in Scotland people spent// an average of ?636 on ... in Wales. ,The demand of the charity is ... ,"These regional variations are shocking and grossly unfair - cancer ...
... to heart abnormalities, is apparently safe to use in ... yesterday//. The researchers said that they found no ... their pregnancies fearing that the drug could affect their ... studied 119 women treated with Seroxat for six years ...
... suffering, a tuberculosis (TB) patient in Madhya Pradesh has requested Indian ... life and that of his four minor children. ... late 40s, is suffering from TB and has long been dependent ... of TB a few years ago. ,He has now ...
... chemical compound found in cannabis, also known as hashish ... after testing it on rats //. ,Yehoshua ... Israel, has created a synthetic version of a minor ... help in lowering blood pressure, reported science portal The ...
... a common school system in the country, educationists Sunday ... primary education //system and remove disparities among students. ... system in the country so that all students get ... said Madhu Prasad, educationist and a professor in Delhi ...
... Administration borrowed data from the 2004 National Survey on ... persons, 12 years of age or older, made ... to the survey. Meanwhile, an estimated 2.1 million Americans ... cocaine abuse. ,The statistics revealed the following ...
Cached Medicine News:
(Date:7/10/2014)... -- Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... sale to Galderma of all rights to Restylane, Perlane, ... for $1.4 billion in cash, pursuant to the previously ... acquisition of Galderma. "We are pleased ... company that is firmly committed to the aesthetic dermatology ...
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:7/10/2014)... 10, 2014 CVS Caremark Corporation (NYSE: ... approved a quarterly dividend of $0.275 (27.5 cents) per share ... August 1, 2014, to holders of record on July 21, ... Caremark is dedicated to helping people on their path to ... the United States . Through the company,s more ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... 20, 2012  NxStage Medical, Inc. (Nasdaq: NXTM ... announced plans to release its financial results for the ... on Wednesday, February 29, 2012  before the opening of ... ) NxStage will also host a conference ...
... 2012  INVO Bioscience, Inc. (OTC BB: IVOB), a medical ... with infertility, today announced that the National Health Surveillance ... INVOcell for use as a Class II device. This ... of infertile couples in Brazil and marks a major ...
Cached Medicine Technology:NxStage® to Report Fourth Quarter and Full Year 2011 Financial Results 2INVO Bioscience Announces Approval of INVOcell by Brazil's ANVISA 2INVO Bioscience Announces Approval of INVOcell by Brazil's ANVISA 3
... eliminate false signals and contamination caused ... Promega Barrier Tips offer performance and ... acids (PCR(a)), radioactive isotopes, tissue culture ... specimens. , ,Promega Barrier Tips are ...
... tips eliminate false signals and contamination ... tested, Promega Barrier Tips offer performance ... nucleic acids (PCR(a)), radioactive isotopes, tissue ... serological specimens. , ,Promega Barrier Tips ...
... AvantGard Low Binding 0.5l - 10l Eppendorf ... binding technology that significantly reduces the amount of ... other filter tips are advertised as low retention, ... adhering to the pipet tip. However, AvantGard also ...
10 L, Racked, Filtered, Pre-sterilized, 96 tips/rack Recommended for 2, 5 and 10 L pipettes....
Medicine Products: