Navigation Links
Cancer-associated long noncoding RNA regulates pre-mRNA splicing
Date:9/24/2010

CHAMPAIGN, Ill. Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing a critical step in the earliest stage of protein production. Their study appears in the journal Molecular Cell.

Nearly 5 percent of the human genome codes for proteins, and scientists are only beginning to understand the role of the rest of the "non-coding" genome. Among the least studied non-coding genes which are transcribed from DNA to RNA but generally are not translated into proteins are the long non-coding RNAs (lncRNAs).

Before the human genome was fully sequenced, it was a "protein-centric world," said University of Illinois cell and developmental biology professor Kannanganattu Prasanth, who led the study. With the sequencing of the genome it became clear, however, that a majority of genes code for RNAs that are not translated into proteins.

In recent years, research on non-coding RNAs has blossomed, but most studies have focused only on small non-coding RNAs, which play critical roles in several aspects of cellular function. There have been comparatively fewer studies on lncRNAs, Prasanth said. As a result, researchers are only beginning to understand the functions of a few lncRNAs.

Prasanth's laboratory focuses on understanding the role of lncRNAs, such as MALAT1, which normally are distributed in the nucleus of mammalian cells.

Preliminary studies suggest that lncRNAs carry out vital regulatory functions in cells. When those functions go awry, Prasanth said, serious consequences can result. Abnormal expression of the MALAT1 gene, for example, is implicated in many cancers, including breast, lung and liver cancers, "so the scientific world was interested in what this RNA could be doing in normal cells, and how changes in its expression correlate with cancer," he said.

Prasanth was also the co-first-author of another study, recently publis
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Linc-ing a noncoding RNA to a central cellular pathway
2. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
3. Adiposity hormone, leptin, regulates food intake by influencing learning and memory
4. A single protein regulates 2 immune pathways
5. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
6. U of T researchers crack splicing code, solve a mystery underlying biological complexity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-associated long noncoding RNA regulates pre-mRNA splicing
(Date:8/22/2014)... August 22, 2014 AttorneyOne.com, a recognized ... the latest information from the FDA on Diamondback ... US FDA announced on August 19, that certain lots ... number DPB-125MICRO145 (Part number 7-10003), by Cardiovascular Systems, are ... sheaths that could fracture during use and could possibly ...
(Date:8/22/2014)... August 22, 2014 Reacting to naysayers ... Rich Plasma therapy (PRP), a top PRP therapy LA ... therapy has everything to do with practical well researched ... hype. PRP therapy is a new medical breakthrough technology ... and bones using the PRP therapy. , The Managing ...
(Date:8/22/2014)... 22, 2014 Teen substance abuse has long ... The rising numbers of young adults falling victim to a ... help make a difference in the community, the new Troubled ... for teens seeking to overcome their chemical dependency. The helpline ... best youth rehab center to focus on achieving sobriety. , ...
(Date:8/22/2014)... 22, 2014 The rising numbers of ... OH. Over the years, countless lives have been lost due ... difference in the community a new helpline was established to ... in Northeast Ohio who are seeking to overcome their chemical ... helpline at (300) 400-2616, parents and their teens can speak ...
(Date:8/22/2014)... Carolina Senior Living Apartments, owned and operated ... recently opened 30 spacious one-bedroom affordable residential units ... in Lexington, NC. Each unit is equipped with ... heating and cooling system, and secured entry. ... of a three-story building with an elevator and ...
Breaking Medicine News(10 mins):Health News:Diamondback 360 Peripheral Orbital Atherectomy System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:MetroMD With The Help Of PRP Therapy Helps People Fight Hip Injuries 2Health News:New Helpline Provides Hope for Troubled Teens in Toledo 2Health News:Troubled Teens in Akron, OH Can Receive Assistance from New Helpline for Addiction Recovery 2Health News:United Church Homes and Services Announce New Affordable Housing Community for Seniors 2
... V. Bennett is Named as the President and CEO ... Halo Pharmaceutical, a privately held specialty pharmaceutical company, has ... to be called Halo Pharmaceutical Marketing (Canada) Ltd. This ... its main purpose will be the marketing, sale and ...
... now faced with a single benefit decision when selecting long-term care insurance. ... ... complexities involved in selecting long-term care insurance are scaring you off, ... simpler long-term care insurance product with few options to confuse the decision-making ...
... Legislature to "See the light on smokefree air"INDIANAPOLIS, March ... denominations today joined the fight to reduce the devastating ... asking legislators to pass a comprehensive smokefree law that ... Faith leaders will march to the State House and ...
... of the World,s Most Admired CompaniesEL SEGUNDO, Calif., March ... care services, today accepted the honor by FORTUNE ... facilities in the country. DaVita(R) ranked #1 in the ... Investment and Quality of Products and Services. Overall, the ...
... UC Irvine neuroscientists have received $2 million to ... findings could lead to clinical research and treatment of ... UCI scientists hope to gain a greater understanding of ... the auditory cortex. , "We still don,t know how ...
... N.J., March 3 Cantel Medical Corp. (NYSE: ... Company,s results for its second quarter ended January 31, 2009 ... in the call will be Charles M. Diker, Chairman; Andrew ... CFO; and Roy K. Malkin, President of Minntech Corporation. Minntech ...
Cached Medicine News:Health News:Halo Pharmaceutical Launches a Branded Product Marketing Company in Canada 2Health News:Prudential Long-Term Care Product Simplifies Decisions 2Health News:Prudential Long-Term Care Product Simplifies Decisions 3Health News:Indiana's Faith, Health Leaders Join Push for Comprehensive Smokefree Law 2Health News:FORTUNE Magazine Ranks DaVita #1 Health Care Medical Facility in Innovation, Investment and Quality 2Health News:Cantel Medical Corp. to Hold Conference Call to Discuss Results for Its Second Quarter Ended January 31, 2009 2
(Date:8/21/2014)... 21, 2014  Vermillion, Inc. (NASDAQ: VRML ... and women,s health, has appointed Holly B. Bauzon ... Ms. Bauzon has a proven track record ... for laboratory services companies. She has more than 20 ... where she held the position of Director, Lab Services ...
(Date:8/21/2014)... , Aug. 21, 2014  eRelevance Corporation ( ... announced today that it has completed integration with ... for Plastic Surgery and Dermatology practices. ... value to healthcare practices using Nextech," stated ... Corporation. "Using information from the EMR we are ...
(Date:8/21/2014)... YORK , Aug. 21, 2014  Publicis Groupe ... Shannon Hartley , Managing Partner and Healthcare Industry Group ... PharmaVoice 100, which recognizes the most inspiring people in ... are leaders in research and development, marketing, technology, creativity, ... agency in 2006 as a partner in its leading ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Shannon Hartley Shines in PharmaVOICE 100 2
... BRIDGEWATER, N.J., Oct. 8 Advanced Health Media, LLC ... marketing services and related technology for the pharmaceutical and ... industry leader in speaker bureau management, supplying automation and ... and coordinating promotional events for more than 200 brands. ...
... Oct. 8 Cancer treatments are on track to become ... to overall drug spending hit five percent for the first ... Health Solutions, Inc. (NYSE: MHS). Oncology specialty drug spending ... conditions and multiple sclerosis as a specialty drug growth driver. ...
Cached Medicine Technology:Advanced Health Media Announces Acquisition of Ephikacy, LLC 2Advanced Health Media Announces Acquisition of Ephikacy, LLC 3Cancer Drugs Emerging as Top Driver of Specialty Drug Spending 2Cancer Drugs Emerging as Top Driver of Specialty Drug Spending 3Cancer Drugs Emerging as Top Driver of Specialty Drug Spending 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: