Navigation Links
Cancer Stem Cells Created in Lab
Date:4/9/2008

Experts say discovery could unlock secrets of cancer one day

WEDNESDAY, April 9 (HealthDay News) -- Researchers at Stanford University have succeeded in transforming skin cells into what appear to be cancer stem cells, in a feat that could propel cancer research forward.

Cancer stem cells are thought to start the unhindered proliferation of cells which ultimately results in cancer.

"This has the potential for unlocking some of the secrets of cancer," said Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society, which supported the study.

"This means that now you have a good way to study cancer cells and the mechanisms involved versus getting a piece of the tumor," added Paul Sanberg, distinguished professor of neurosurgery and director of the University of South Florida Center for Aging and Brain Repair in Tampa. "Here, you have more control, more ability to look at genetic consequences and the effects of developing new therapies."

"This might allow you to identify cancers that are going to be more aggressive earlier on and allow you to tailor therapies," noted Dr. Fabrice Roegiers, co-director of the Keystone Program for Epigenetics and Progenitor Cells at Fox Chase Cancer Center in Philadelphia. "In the future, being able to identify which cancers are really being driven by the stem cell population will allow us to target those sooner."

The work, published in the April 10 issue of Cell Stem Cell, also noted that cancer stem cells are closer to embryonic stem cells (which can develop into all tissue types) than adult stem cells (which are more limited in what types of tissue they can become). This discovery could shed light on how tumors originate.

Thus far, however, researchers have been hindered in their efforts to understand this type of cell, because they are rare and difficult to grow in the lab. And, added Roegiers, there is still some controversy as to whether this type of cell actually exists in tumors.

For this study, researchers reviewed existing data on gene expression patterns in various stem cell populations and ultimately came up with two different groups: one that is closer to most adult stem cells and one that's closer to embryonic stem cells.

They were also able to detect the "signature" of the embryonic stem cells in certain tumor samples and to note that these tumors tended to be more aggressive.

The findings have implications for future therapies that might be derived from stem cells. The researchers found that one oncogene, "Myc," seems to be a key regulator in converting skin cells to stem cells. But when overexpressed, this gene can induce tumors. If stem cells are created with Myc, then put back into a patient for therapy, there is also the possibility that it will stimulate cancer growth.

"As they're clearly showing, Myc is capable of reprogramming cells into stem cells, but it does that in tumors as well," Roegiers said. "It will be really important to see what Myc is doing and whether it's possible to create these types of stem cells in the lab in a way that will not threaten people when you introduce these cells."

More information

Visit the American Cancer Society for more on different types of cancer.



SOURCES: Paul Sanberg, Ph.D., D.Sc., distinguished professor of neurosurgery and director, University of South Florida Center for Aging and Brain Repair, Tampa; Len Lichtenfeld, M.D., deputy chief medical officer, American Cancer Society, Atlanta; Fabrice Roegiers, Ph.D., co-director, Keystone Program for Epigenetics and Progenitor Cells, Fox Chase Cancer Center, Philadelphia; April 10, 2008, Cell Stem Cell


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cancer widows are often emotionally isolated
2. Kidney cancer deaths show overall decrease in Europe
3. Looping genes may hold a key to understanding breast cancer
4. Breast Cancer Lymph Node Biopsy May Need Closer Look
5. Nuvelo Announces Presentations on NU206 and rNAPc2 at 2008 American Association for Cancer Research Annual Meeting
6. European Society for Medical Oncology and European CanCer Organization join forces
7. Stopping a cancer trial early: is it for the benefit of patients or industry?
8. High-intensity chemotherapy does not improve survival in small cell lung cancer
9. Scientists Block Prostate Cancer Cells Spread
10. Two Liver Cancer Treatments Better Than One
11. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Stem Cells Created in Lab
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
(Date:6/23/2016)... , June 23, 2016 Leading ... that address medical conditions resulting from a breakdown ... has appointed Greg Doyle as chief ... Leading BioSciences, executive management team and board of ... chief financial officer. He will provide continued leadership ...
Breaking Medicine Technology: