Navigation Links
Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer
Date:6/25/2009

organ development would be significant."

Hill says not everyone who inherits a mutation develops PPB and children with PPB are typically normal in every other way. The team theorizes that something else must happen to the normal copy of DICER1 in lung cells for a tumor to develop. When the research team looked at PPB tumors to see if there is any DICER1 protein being made from the remaining normal copy of the gene, they were surprised by the results: "We expected to see that the tumor cells had no DICER1 protein giving us a nice explanation for why the tumor cells had gone haywire." But that wasn't the case. They found that the benign cells that grew on the surface of the tumor had lost the DICER1 protein. "During lung development the cells that line the airways and the cells that make up the support structures have to communicate." Hill explained. "Loss of DICER1 in the airway lining cells could disrupt this communication, possibly setting the stage for abnormal growth."

Studying tumor cells for genetic mutations has led to many advances in the understanding of cancer. This discovery may represent a first step in understanding a new mechanism for how cancer begins. Conceivably, the mutated cells do not turn into tumors themselves. Instead, these cells influence surrounding cells to grow quickly, setting the stage for additional genetic mutations in cells that then become cancerous. Hill's team will now focus on demonstrating the sequence of events that result from loss of DICER1.

Only 50 or 60 cases of PPB are diagnosed worldwide each year. The cancer presents as cysts in early stages and progresses to solid lung tumors over time. If detected in the earliest stages, 90 percent of patients appear to be cured when treated with a surgical intervention and sometimes chemotherapy.

The research was conducted at Children's National Medical Center, the International Pleuropulmonary Blastoma Regist
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer
(Date:4/27/2015)... A' Design Award and Competition is pleased to ... Boombang Inc Design Team has been announced as a ... Instruments, Medical Devices and Research Equipment Design Competition ... Inc Design Team, the creative team behind the awarded ... Lumica is a two-way communication device between patients and ...
(Date:4/27/2015)... On May 15, Mount Soma Ashram students (monks) ... raise awareness of the vision of Mount Soma; the ... Ironically, when many of these people moved to the ... were leaving the social and technological world behind. Ashram ... service to a higher cause, deep introspection, and renunciation ...
(Date:4/27/2015)... April 27, 2015 The global ... a lower CAGR in developed countries; however, it ... countries such as China, India and Brazil in ... analyzers market is driven by factors such as ... laboratories, development of high-throughput hemostasis analyzers, developments in ...
(Date:4/27/2015)... 27, 2015 Healthpointe clinics throughout Southern ... nail fungi and infections. Onychomycosis, which is commonly known ... 10% of adults in the Western population. This fungal ... thickness. , Healthpointe’s Anaheim clinic is home ... dedicated to providing quality skincare products and restorative services. ...
(Date:4/27/2015)... 2015 Scooter Direct is now offering ... discounted price of only $929.00, marked down from the ... store is known for offering quality mobility solutions to ... lifts, wheel chairs, lift chairs, and their accessories at ... features of Go Go Traveller Elite, a senior store ...
Breaking Medicine News(10 mins):Health News:Boombang Inc Design Team wins Platinum in A' Medical Product Design Awards 2Health News:Mount Soma Monks Do Social Media 2Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 2Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 3Health News:Southern California Healthpointe Clinics Now Treating Nail Fungus 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 3
... , WHITE PLAINS, N.Y., July 14 A new ... - alerting them to a patient,s increased risk for birth defects ... agreement with a $1.2 million grant from the Health Resources and ... The National Coalition for Health Professional Education in Genetics ...
... ... and senior partner at the Pederson Immigration Law Group, P.C. is slated to be ... , ... (PRWEB) July 14, 2009 - The Pederson Immigration Law Group, P.C., (PILG) announced that ...
... , , , ... leading provider of electronic medical records systems, electronic prescribing and advanced ... on June 24(th), 2009. meridianEMR users will now be able to ... in communities throughout all 50 states and Washington, D.C. , ...
... 14, 2009 News media covering chemical sciences, small ... Chemical Society (ACS) Small & Medium Business Webinar on ... and entrepreneurs. Scheduled for Thursday, July ... will feature Kenneth Polk, who joined ACS in October ...
... KANSAS CITY, Mo., July 14 We have all heard this warning: ... Do we first notice the hair, the eyes, or the clothing? ... smile is the first feature we notice about someone. Smiling is also ... we should all be interested in making sure we are taking care of ...
... 14 To help the general public better understand the ... on Skin Cancer Prevention has issued a position statement on ... recommends that vitamin D be obtained from a combination of ... ultraviolet (UV) radiation. , , ...
Cached Medicine News:Health News:New HHS HRSA Grant Will Fund Development of an Electronic Genetic and Family History Record for Doctors' Offices 2Health News:New HHS HRSA Grant Will Fund Development of an Electronic Genetic and Family History Record for Doctors' Offices 3Health News:Pederson Immigration Law Group Attorneys Featured in 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 2Health News:Pederson Immigration Law Group Attorneys Featured in 14th Annual J-1/H-1B Foreign Physician Immigration Conference and Job Fair Series 3Health News:meridianEMR Completes Surescripts(R) Certification 2Health News:meridianEMR Completes Surescripts(R) Certification 3Health News:Want to attract the opposite sex? It's in the Smile. 2Health News:National Council on Skin Cancer Prevention Encourages Americans to Obtain Vitamin D Through Diet and Supplements 2
(Date:4/27/2015)... , April 27, 2015  Boston Scientific Corporation (NYSE: ... America Merrill Lynch 2015 Healthcare Conference on May 12 in ... Brennan , executive vice president and chief financial officer, and ... in a 30-minute question and answer session regarding the company ... A live webcast of the presentation and question and ...
(Date:4/27/2015)... and WASHINGTON , April 27, 2015 ... and SmartBrief recently partnered to deliver a daily newsletter ... the top news in the industry. The purpose of ... biotechnology manufacturers, GPOs, distributors and other specialty pharmacy stakeholders ... on April 27, 2015. "We are looking ...
(Date:4/27/2015)... , April 27, 2015 The ... estimated to grow to around $4,211.2 million by 2019, at ... Browse through the TOC of the North America ... of the in-depth analysis provided. It also provides a glimpse ... and is supported by various tables and figures. ...
Breaking Medicine Technology:Boston Scientific To Participate In The Bank Of America Merrill Lynch 2015 Healthcare Conference 2NASP and SmartBrief Partner on Specialty Pharmacy SmartBrief 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 3
... -- ShangPharma Corporation (NYSE: SHP ) ("ShangPharma" ... research and development outsourcing company, today announced that it ... in its biologics division, which portends strong growth for ... milestones were achieved for two oncology projects that are ...
... WuXi PharmaTech (Cayman) Inc. (NYSE: ... the pharmaceutical, biotechnology, and medical device industries, with operations in ... for the second quarter of 2011. Highlights ... Million for the First Time Second-Quarter 2011 Net ...
Cached Medicine Technology:ShangPharma's Biologics Division Announces Accelerated Achievement of Milestones for Two Multi-Stage Projects 2WuXi PharmaTech Announces Second Quarter 2011 Results 2WuXi PharmaTech Announces Second Quarter 2011 Results 3WuXi PharmaTech Announces Second Quarter 2011 Results 4WuXi PharmaTech Announces Second Quarter 2011 Results 5WuXi PharmaTech Announces Second Quarter 2011 Results 6WuXi PharmaTech Announces Second Quarter 2011 Results 7WuXi PharmaTech Announces Second Quarter 2011 Results 8WuXi PharmaTech Announces Second Quarter 2011 Results 9WuXi PharmaTech Announces Second Quarter 2011 Results 10WuXi PharmaTech Announces Second Quarter 2011 Results 11WuXi PharmaTech Announces Second Quarter 2011 Results 12WuXi PharmaTech Announces Second Quarter 2011 Results 13WuXi PharmaTech Announces Second Quarter 2011 Results 14WuXi PharmaTech Announces Second Quarter 2011 Results 15WuXi PharmaTech Announces Second Quarter 2011 Results 16WuXi PharmaTech Announces Second Quarter 2011 Results 17
... of German Craftsmanship have produced ... the world. Ocutek now makes ... holders of the coveted Meisterbrief ... apprenticeship, are qualified to become ...
1mm by 7mm horizontal punch. Flat serrated handle. Overall length 87mm....
... integrated neck. Piston assembly fits into ... spring to recoil back to ready ... into precision milled cavity in platform. ... - 9.0mm. Designed for the preparation ...
Adjustable piston accommodates 7-9mm trephine blade. Complete punch includes base plate, piston carrier, piston for 7 - 9mm trephine blades and 18mm diameter Teflon block. Designed for accurate donor...
Medicine Products: