Navigation Links
Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer
Date:6/25/2009

Finding may have implications for gene's role in other cancers

Washington, DC (Vocus) June 25, 2009 -- Research published today in Science Express from the journal Science demonstrates the first definitive link between mutations in the gene DICER1and cancer. By studying the patterns of DNA from 11 families with an unusual predisposition to the rare childhood lung cancer pleuropulmonary blastoma (PPB) investigators from Children's Natioanl Medical Center and several other institutions found that children with the cancer carried a mutation in one of their two DICER1 gene copies.

DICER1 makes an important protein that works to suppress other genes through intermediary molecules known as microRNAs. Scientists have learned that microRNAs can fine-tune the expression of many other genes, which is particularly important in normal human development. Recent research has also focused on DICER1 as having a potential role in cancer because the micro-RNA molecules it produces appear vastly different from normal when found in cancer cells; some suggest that the pattern of microRNAs in cancers resembles an embryonic stage.

"When we realized that DICER1 was in the segment of chromosome that was shared among children with PPB we were very excited," said D. Ashley Hill, MD, lead author and chief of Pathology at Children's National Medical Center. "PPB is a tumor that appears to arise out of a localized area of abnormal lung development. The implications of a defect in a master controller gene for normal
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer
(Date:3/1/2015)... Atlanta, GA (PRWEB) March 01, 2015 ... of Evelyn King and Carolyn Roddy to the professional ... Director of Compliance, graduated from The Ohio State University-Mortiz ... over 15 years of experience working with several Fortune ... specifically in the area of corporate benefits. Her experiences ...
(Date:2/28/2015)... February 28, 2015 In recent years Medical ... of practicing physicians as a way for them to expand ... regarding Cannabis as medicine. Since the FDA still lists Cannabis ... resources available to licensed physicians that can help guide ... Dr. Deborah Malka in Santa Cruz, CA is a ...
(Date:2/28/2015)... The Heart Fit Clinic started doing ... the machine. The Heart Fit Clinic is also selling ... franchise model. The goal is to scale the business ... To buy External Counterpulsation machines can be ... through this process and achieve the desired results. ...
(Date:2/28/2015)... 2015 Indosoft Inc , developers ... Asterisk, are pleased to announce the development of Q-Suite ... 5.8 versions of Q-Suite, this new version will include ... of new features to the leading edge call center ... 5.9 will add features to enhance security and protection. ...
(Date:2/28/2015)... February 28, 2015 National ... outsourced sales, marketing and supply chain management for ... Botanicals, is bringing its award winning solutions for ... Botanicals’ products are specifically created to combat thinning-damaged ... BIOTA is committed to marrying science with nature ...
Breaking Medicine News(10 mins):Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3
... said that suicide rates in Sri Lanka has increased in multifold ... oleander plants even for the most trivial reasons. ,This ... over the island. It has yellow trumpet-like flowers and a fruit ... and one of these seeds is enough to kill you, the ...
... Ashok Bhatt has confirmed the absence of bird-flu cases in ... yielded negative results. ,Kadar Murghiwala, a poultry dealer ... died. Suspecting a possible bird-flu infection following complaints of fever, ... an isolation ward. The symptoms of bird-flu as listed by ...
... diabetes. New South Wales (NSW) has recorded a 300% increase ... 10 years. Experts have asked the health system and the ... it continues it is expected that about 2 million will ... increase is that of the diet and lifestyle factors. About ...
... revamp the drug system. Health Minister George Smitherman said ... drug program//. He also said that he would introduce ... and sustainable. They will also speed up the slow ... The taxpayers have not received fair value for their ...
... infant and maternal mortality rates in the state, Madhya Pradesh ... a study conducted by a voluntary group//. ,The state, ... mortality rate of 83 per 1,000 childbirths while the maternal ... ,"Despite Madhya Pradesh having the second highest rate of ...
... chemical in the United States. It is obtained primarily ... yellow liquid at room temperature//. It has a sweet ... both natural processes and human activities. Benzene is also ... It is of exceptional importance commercially on account of ...
Cached Medicine News:Health News:Its High Time the Australian Government Takes Steps against Diabetes 2Health News:The Multi-Faceted Chemical Benzene 2Health News:The Multi-Faceted Chemical Benzene 3Health News:The Multi-Faceted Chemical Benzene 4Health News:The Multi-Faceted Chemical Benzene 5Health News:The Multi-Faceted Chemical Benzene 6
(Date:2/26/2015)... Feb. 26, 2015  IRIDEX Corporation (NASDAQ: IRIX ... and full year 2014 financial results after the market closes ... the release, the Company will host a conference call with ... Thursday, March 5, 2015 to discuss the ... Interested parties may access the live conference call via telephone ...
(Date:2/26/2015)... WASHINGTON , Feb. 26, 2015  Mail-service ... consumers, employers and government health plans ... research released by the Pharmaceutical Care Management Association ... specialty drugs offers one of the easiest ways ... CEO Mark Merritt . "Policymakers should resist ...
(Date:2/26/2015)... Feb. 26, 2015 Every year many millions ... fight heart disease.  Nevertheless, year after year doctors and ... as the first test to determine the status of ... pain or not, even though that technology is over ... fact that doctors know, (while most patients do not ...
Breaking Medicine Technology:IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Texas Employers, Consumers and Public Programs by $23.3 Billion 2National Heart Health Month In February 2
... the first time, consumers shopping for over-the-counter products ... that appears on the skin, affecting as many ... and tendon disease—will find a National Psoriasis Foundation ... deem effective in relieving disease symptoms. Learn about ...
... 28, 2012  On February 28th, 2012, the New York ... interested in speaking at its 2012 Digital Health Conference, ... City,s Pier Sixty. At NYeC,s inaugural ... York City—over 600 healthcare providers, healthcare technology companies, IT ...
Cached Medicine Technology:National Psoriasis Foundation Launches "Seal of Recognition" for Psoriasis Products 2National Psoriasis Foundation Launches "Seal of Recognition" for Psoriasis Products 3Call for Speakers: New York's Digital Health Conference 2012 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: