Navigation Links
Cancer Drugs May Treat Type 1 Diabetes

Experiments in mice show Gleevec and Sutent reverse, prevent autoimmune disease

TUESDAY, Nov. 18 (HealthDay News) -- Gleevec, a wonder drug that effectively treats leukemia and other cancers, may also reverse type 1 diabetes, University of California San Francisco, researchers report.

In experiments with mice, they found that Gleevec and a similar cancer drug, Sutent, could prevent the onset of type 1 diabetes. Type 1 diabetes is usually diagnosed in children and young adults, and is caused by the inability of the body to make insulin.

"Although targeted to the Bcr-Abl kinase, Gleevec has been shown to affect related kinases including platelet-derived growth factor potentially involved in various cell types critical to the development and progression of autoimmune diseases such as type 1 diabetes," lead researcher Jeffrey Bluestone, director of the Diabetes Center at the University of California, San Francisco, said.

The study shows that this class of drugs could prevent and reverse diabetes in a mouse model of type 1 diabetes, Bluestone said. "Moreover, a significant percentage of the animals remain in long-term remission even after discontinuation of the therapy," he added.

The report was published in this week's online issue of the Proceedings of the National Academy of Sciences.

In their experiments, Bluestone's team found that in mice treated with Gleevec (imatinib) and Sutent (sunitinib) for seven weeks before the onset of type 1 diabetes did not develop the disease long after treatment was stopped.

In addition, they found that 80 percent of the animals who had type 1 diabetes had their disease reversed when given Gleevec or Sutent for eight to 10 weeks.

Drugs in the same class might be used to treat type 1 diabetes and other autoimmune diseases, Bluestone said. In addition, the study shows the role platelet-derived growth factor may play in causing type 1 diabetes, he said.

Teodora Staeva, from the Juvenile Diabetes Research Foundation International, thinks the results of the study are important, but whether the drugs can treat diabetes in people safely still has to be established.

"What is exciting is that this is a new class of compounds to modulate autoimmunity," Staeva said. "The findings here suggest that they may be potentially useful in type 1 diabetes."

Staeva noted that other drugs have been able to reverse diabetes, but when the drug is stopped, the disease comes back immediately. "What is encouraging here is that when they stopped the 10-week regimen, they still see a prolonged remission from the disease," she said.

Despite these encouraging findings, Staeva isn't sure how well the results will translate into human diabetics. "The biggest unknown right now is the safety," she said.

"Where one is not dealing with a life/death situation, one has to be much more careful about the potential safety of the drug," she said.

More information

For more about type 1 diabetes, visit the Juvenile Diabetes Research Foundation International.

SOURCES: Jeffery Bluestone, Ph.D., University of California, San Francisco, Diabetes Center; Teodora Staeva, Ph.D., Juvenile Diabetes Research Foundation International, New York City; Nov. 17-21, 2008, Proceedings of the National Academy of Sciences, online

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cold Spring Harbor science teams identify 13 new tumor-suppressor genes in liver cancer
2. Cancer Drug Ups Risk of Clots in Veins
3. Fred Hutchinson Cancer Research Center Benefits From Shopping Site
4. Diet, Exercise May Modify Breast Cancer Risks
5. Home-Based Programs Benefit Older Cancer Survivors
6. Canola Oil Consumed During Pregnancy Lowers Breast Cancer Risk for Offspring
7. Genetic Trait Could Predict Lung Cancer
8. Home-based diet and exercise intervention improves elderly cancer survivors physical function
9. Cancer survival rates impact type of Web communities used by patients
10. Non-AIDS Cancer Risk Higher for Those With HIV
11. A postcode lottery still exists for cancer patients with exceptional circumstances
Post Your Comments:
Related Image:
Cancer Drugs May Treat Type 1 Diabetes 
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about ... intend to develop to enable prevention of a major side effect of chemotherapy ... especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a ... of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners ... October 11, 2017. , The annual award competition recognizes editorial and design excellence across ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, ... relay – Miles by Moonlight to raise money for the American Heart Association Heart ... , Teams will work together to keep their treadmills moving for 5 hours. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations ... literacy software tool, and the Cancer Patient Education Network (CPEN), an independent professional ... announce a new strategic alliance. , As CPEN’s strategic partner, HLI will ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 2017  NDS received FDA 510(k) clearance in May 2017 for ... stand specifically designed for endoscopy environments. An innovative secondary monitor solution, ... solution to support the improvement of patient outcomes, procedural efficiency, and ... ... ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
Breaking Medicine Technology: