Navigation Links
Cancer Drug Safe for Late-Stage Pelvic Disease
Date:4/7/2010

Vorinostat can be used with radiotherapy in palliative care, study finds

WEDNESDAY, April 7 (HealthDay News) -- It's safe to use a new oral anti-cancer drug called vorinostat with short-term palliative radiation therapy in patients with advanced pelvic cancer, according to a phase 1 study.

Palliative therapy is used to help control symptoms in patients who can't be cured.

Radiation therapy is an effective palliative treatment to control pain and bleeding in patients with advanced pelvic cancer who aren't eligible for curative radiation therapy or surgery. Vorinostat -- a type of histone deacetylase (HDAC) inhibitor -- is believed to stop tumor growth by altering the expression of several genes necessary for cancer growth.

This study included 16 patients who received either 100 milligram, 200 mg, 300 mg, or 400 mg daily doses of vorinostat three hours before pelvic palliative radiation to 30 Gy in 3 Gy daily fractions over two weeks.

Nausea, diarrhea and anorexia were the most common side effects experienced by all the patients. Biological activity of vorinostat was detected in patients who received the lowest and highest levels of the drug. Most patients had an overall decrease in tumor size six weeks after they completed the combined treatment.

"These observations show that vorinostat can be safely combined with a standard palliative radiotherapy regimen to treat advanced pelvic cancer," wrote Prof. Anne H. Ree of Norwegian Radium Hospital in Oslo and colleagues.

"This study adds to mounting evidence supporting the use of HDAC inhibition in cancer therapy. These data encourage further examination of this class of molecularly targeted agents in clinical radiotherapy," they concluded.

The study was published online April 6 in The Lancet Oncology.

More information

The U.S. National Institutes of Health has more on palliative care.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, April 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New study implicates health care utilization, over biology, in colorectal cancer disparities
2. Mount Sinai study finds only a weak link between fruit and vegetable and reduced risk of cancer
3. Fruits, Veggies Have Modest Effect on Cancer Risk
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Childhood cancer survivors may face shortened lifespan, study reveals
6. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
7. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
8. Childhood Cancer Survivors At Higher Odds of Early Death
9. Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer
10. New investigation supports correlation between XMRV and prostate cancer
11. New Breast Cancer Book Offers Humor Filled Look at Being Thirty-Something, Single And Getting Through Diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... ... will feature the Aurum Group in an upcoming episode, slated to air fourth ... Innovations will feature the Aurum Group; a company committed to supporting dentistry using ...
(Date:8/19/2017)... ... 2017 , ... Paragon and IOTA ... the cannabis industry move towards greater legitimacy. By incorporating IOTA’s unique approach to ... lower fees. Paragon will build a fully verifiable database to track prescriptions, and ...
(Date:8/19/2017)... (PRWEB) , ... August 19, 2017 , ... ... announced that it is the first organization with pending recognition status from the ... Prevention Program (“DPP”) via group telehealth classes and live video conferencing. , ...
(Date:8/19/2017)... ... August 19, 2017 , ... Praeclarus ... breastfeeding mothers. These illustrations show the diversity of the breastfeeding mothers, using ... wide range of sizes. These illustrations are also available on tote bags, notepads, ...
(Date:8/19/2017)... ... August 19, 2017 , ... Parker at ... of over 1,000 passionate employees, caregivers, volunteers, thought leaders, researchers, educators and partners ... ownership, it was time to refresh the carpeting with the goal of maintaining ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Pharmaceuticals Inc., the creator of the drug Truveta for the ... an IPO. The United States spends ... a prescription epilepsy drug being $450.00-$1200.00 for a one month supply. ... AXIUM PHARMACEUTICALS, INC ... figure is the fact that Americans spent $42 billion on anxiety medications ...
(Date:8/11/2017)... , Aug. 11, 2017 DarioHealth Corp. ... mobile health and big data solutions, today announced that ... Monday, August 14 and host a conference call at ... 2017 operating and financial results and its strategy and ... be hosted by Erez Raphael , Chief Executive ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
Breaking Medicine Technology: