Navigation Links
Cancer Drug Safe for Late-Stage Pelvic Disease
Date:4/7/2010

Vorinostat can be used with radiotherapy in palliative care, study finds

WEDNESDAY, April 7 (HealthDay News) -- It's safe to use a new oral anti-cancer drug called vorinostat with short-term palliative radiation therapy in patients with advanced pelvic cancer, according to a phase 1 study.

Palliative therapy is used to help control symptoms in patients who can't be cured.

Radiation therapy is an effective palliative treatment to control pain and bleeding in patients with advanced pelvic cancer who aren't eligible for curative radiation therapy or surgery. Vorinostat -- a type of histone deacetylase (HDAC) inhibitor -- is believed to stop tumor growth by altering the expression of several genes necessary for cancer growth.

This study included 16 patients who received either 100 milligram, 200 mg, 300 mg, or 400 mg daily doses of vorinostat three hours before pelvic palliative radiation to 30 Gy in 3 Gy daily fractions over two weeks.

Nausea, diarrhea and anorexia were the most common side effects experienced by all the patients. Biological activity of vorinostat was detected in patients who received the lowest and highest levels of the drug. Most patients had an overall decrease in tumor size six weeks after they completed the combined treatment.

"These observations show that vorinostat can be safely combined with a standard palliative radiotherapy regimen to treat advanced pelvic cancer," wrote Prof. Anne H. Ree of Norwegian Radium Hospital in Oslo and colleagues.

"This study adds to mounting evidence supporting the use of HDAC inhibition in cancer therapy. These data encourage further examination of this class of molecularly targeted agents in clinical radiotherapy," they concluded.

The study was published online April 6 in The Lancet Oncology.

More information

The U.S. National Institutes of Health has more on palliative care.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, April 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New study implicates health care utilization, over biology, in colorectal cancer disparities
2. Mount Sinai study finds only a weak link between fruit and vegetable and reduced risk of cancer
3. Fruits, Veggies Have Modest Effect on Cancer Risk
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Childhood cancer survivors may face shortened lifespan, study reveals
6. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
7. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
8. Childhood Cancer Survivors At Higher Odds of Early Death
9. Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer
10. New investigation supports correlation between XMRV and prostate cancer
11. New Breast Cancer Book Offers Humor Filled Look at Being Thirty-Something, Single And Getting Through Diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... ... selected by Tidelands Health, a three hospital system in South Carolina, to provide ... the lookout for technology that enhances communication, drives workflow efficiencies and improves provider ...
(Date:5/3/2016)... ... ... injury law firm Monge & Associates is honoring Moms in the time leading ... their Mother or any other mother figure. , According to law firm founder, Scott Monge, ... to say, “we are choosing to do this by giving free roses to those who ...
(Date:5/3/2016)... ... May 03, 2016 , ... Ogawa World USA introduced ... user friendly Samsung tablet and exclusive Smart Application. The Smart 3D combines the best ... massage with a customized user profile and specialized massage program, each user has a ...
(Date:5/3/2016)... Toronto, ON (PRWEB) , ... May 03, 2016 ... ... been recognized as one of Canada’s top Information and Communication Technology (ICT) companies ... top Canadian and Multinational ICT companies operating in Canada, as ranked by revenue. ...
(Date:5/3/2016)... ... May 03, 2016 , ... Huntington Beach orthopedic doctor , Dr. Rick ... can be used to diagnose and treat joint problems. During this procedure, Dr. Pospisil ... a special lighting system and lens that illuminate and magnify the various structures in ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016   BIOTRONIK , a leader ... Food and Drug Administration (FDA) approval of Iperia ... heart failure patients with access to diagnostic magnetic ... remote monitoring with daily automatic transmission and closed ... in response to physiological demands. ...
(Date:5/3/2016)... OSWEGO, Ore. , May 3, 2016   ... the importance of extending care beyond the implant at ... Sessions, May 4-7 in San Francisco ... with continually delivering the highest quality of patient care ... patients are cared for each and every tomorrow," said ...
(Date:5/3/2016)... 3, 2016 Pharmaceutical giant Johnson ... to a woman who says its talc-based powder products ... Gloria Ristesund $5 million in compensatory damages and ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This is ... company. In February, the same court awarded $72 million ...
Breaking Medicine Technology: