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Cancer Drug May Flush Out 'Hidden' HIV: Study
Date:7/25/2012

By Randy Dotinga
HealthDay Reporter

WEDNESDAY, July 25 (HealthDay News) -- Medications can eliminate any sign of HIV from the bloodstream, but the virus that causes AIDS never vanishes for good. Instead, it hides in the body, waiting to strike again.

Now, researchers report that they may have discovered a way to use a cancer drug to make the infected cells more visible, potentially allowing them to be killed.

It's too early to know if the approach will actually help patients get rid of the virus forever. The optimistic hopes of scientists, who are forever seeking an AIDS cure, could be snarled by side effects or some other medical hitch.

But the findings are a promising start, said study author Dr. David Margolis, a professor of medicine at University of North Carolina at Chapel Hill.

"We just wanted to show that we could get the virus to come out and show itself," he said. "This doesn't tell you that we have a cure for AIDS that everyone can take tomorrow. It begins us on a road to accomplish that goal."

At issue is HIV's ability to hide in the body. Scientists suspect that the virus "hijacks" certain kinds of immune cells -- the ones that remember how to deal with certain kinds of germs -- and lurk inside them. Thanks to this hijacking ability, medications and the immune system itself can't find and kill the virus or prevent it from multiplying.

The virus can move out of the immune cells if AIDS medications fail or if patients stop taking them. That means HIV can't currently be cured.

In the new study, researchers gave single doses of a skin cancer chemotherapy drug called vorinostat (Zolinza) to eight HIV-infected patients. The drug seemed to flush out the hidden virus so it was more easily visible.

None of the patients reported side effects, but they only took one dose.

Manufacturer information for cancer patients who take the drug lists serious side effects including dehy
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