Navigation Links
Cancer Drug May Boost Risk of Gastrointestinal Perforation
Date:5/25/2009

Review of trials finds Avastin with chemo doubles odds

MONDAY, May 25 (HealthDay News) -- The use of the drug bevacizumab (Avastin) in combination with chemotherapy greatly increases the risk of gastrointestinal perforations in cancer patients, new research has found.

These perforations are potentially life-threatening holes in the wall of the stomach, small intestine or large bowel.

Bevacizumab is designed to slow the growth of tumors by cutting off their blood supply. Concerns have been raised about bevacizumab and gastrointestinal (GI) perforation, but so far no clinical trials have proved a significant association, according to a news release.

In this new study, Dr. Sanjaykumar Hapani and colleagues at Stony Brook University Cancer Center in New York analyzed findings from 17 trials that included a total of 12,294 patients with a variety of solid tumors. The overall incidence of GI perforation among the patients was 0.9 percent (the death rate was 21.7 percent), but patients who took bevacizumab were twice as likely to develop GI perforations.

The researchers also found that the risk of GI perforations among patients taking bevacizumab was dose dependent. Compared to patients who didn't take the drug, those who took 2.5 mg/kg per week of bevacizumab were 61 percent more likely to develop GI perforations, while those who took 5 mg/kg per week of the drug had a 167 percent higher risk.

The risk of GI perforation associated with bevacizumab also varied according to tumor type, the study authors found. Patients with advanced colorectal cancer and renal cell cancer had the highest risk, while those with pancreatic cancer had the lowest risk.

"As bevacizumab is used extensively in routine cancer treatment and in clinical trials, it will be increasingly important to recognize symptoms indicating perforation and intervene promptly to reduce morbidity and fatality," the researchers concluded. "Our study might help to identify a subset of patients receiving bevacizumab at high risk of bevacizumab-associated perforation."

The study appears online and in the June print issue of The Lancet Oncology.

More information

The MedlinePlus Medical Encyclopedia has more about GI perforation.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, May 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Research Sheds Light on Breast Cancer Prognosis
2. Sexually Transmitted HPV Linked to Certain Head & Neck Cancers
3. Breast MRI detects additional unsuspected cancers not seen on mammography or ultrasound
4. Many Black Women Refuse Breast Cancer Treatments
5. Is there any association between COX2 and colon cancer?
6. Low Vitamin D Levels May Initiate Cancer Development
7. Advanced Prostate Cancer Deadlier in Younger Men
8. Younger men with advanced prostate cancer have shorter survival times
9. African-American women with advanced breast cancer often forego vital treatment
10. Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction
11. Viral Genetics Has Option Under Issued Key Patent for Cancer Drug
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Drug May Boost Risk of Gastrointestinal Perforation
(Date:5/26/2016)... ... May 26, 2016 , ... Connor Sports, ... as a partner for the Tamika Catchings Legacy Tour that will commemorate ... leader in hardwood basketball surfaces in all forms and levels of the game, Connor ...
(Date:5/26/2016)... ... 2016 , ... Cardiac arrhythmia is a common complication following ... survival, reports a team of UPMC researchers in the largest study of its ... Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead to better ...
(Date:5/26/2016)... ... May 26, 2016 , ... Catalent Pharma Solutions, ... biologics, consumer health and global clinical supply services, today announced two key appointments ... company’s continued investment and strategic growth plans in the Asia Pacific region. , ...
(Date:5/26/2016)... ... ... an effort to provide hair restoration information to the widest possible audience, Dr. Parsa Mohebi ... use the app. Dr. Mohebi, the founder of Parsa Mohebi Hair Restoration, is making all ... Dr. Mohebi says, “The positive response to the Snapchat videos we started last month has ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... treatment for eating disorders, is opening a brand new child and adolescent residential ... 8-17 and their families with even more specialized eating disorder treatment and access ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016 According to a new ... Market - U.S. Industry Analysis, Size, Share, Growth, Trends, and ... the U.S. was valued at US$ 5.89 Bn in 2014 ... from 2015 to 2023 to reach US$ 7.99 Bn in ... and emerging needle free drug delivery devices and the market ...
(Date:5/26/2016)... May 26, 2016   Change Healthcare ... analytics, network solutions and technology-enabled services designed ... entered into a strategic channel partnership with ... software solutions and revenue cycle management services ... and rehabilitation clinics to optimize revenue, operational ...
(Date:5/25/2016)... India , May 25, 2016 ... Animation Market by Type (3D, 2D, 4D), by Therapeutic ... Education), by End User (Medical Device Manufacturers, Hospitals/ Clinics) ... studies the global Medical Animation Market for the forecast ... to reach USD 301.3 Million by 2021 from USD ...
Breaking Medicine Technology: