Navigation Links
Cancer Drug Gleevec Linked to Muscle Damage
Date:6/18/2008

French researchers say the problem can probably strike small percentage of patients

WEDNESDAY, June 18 (HealthDay News) -- French doctors have reported a possible new side effect associated with the cancer drug Gleevec (imatinib), widely used for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors.

In a letter published in the June 19 issue of the New England Journal of Medicine, the doctors describe the case of a 25-year-old woman who developed severe rhabdomyolysis while taking imatinib.

Rhabdomyolysis is the breakdown of muscle fibers resulting in the release of muscle fiber contents (myoglobin) into the bloodstream. The condition can cause kidney damage.

The woman was taking imatinib (daily dose of 400 mg) in a clinical trial for the treatment of aggressive fibromatosis (desmoid tumors) that couldn't be treated with surgery. Shortly after the start of drug treatment, the woman experienced symptoms of rhabdomyolysis.

After she stopped taking imatinib, her symptoms ceased. She then agreed to take the drug again while under medical surveillance. Twenty-four hours after she received the first daily dose of 100 mg, she suffered severe symptoms. The drug treatment was halted, and her symptoms disappeared in three days.

The woman's desmoid tumors were treated with radiotherapy, and she has not experienced any recurrence of rhabdomyolysis symptoms.

"We considered our patient's rhabdomyolysis to be induced by imatinib because of the temporal relationship (the rhabdomyolysis occurred within a few days after the initiation of imatinib therapy), the recurrence of rhabdomyolysis with the reintroduction of the drug, and normalization of the creatine kinase level after discontinuation of the drug. Although there is extensive clinical experience with the safe use of imatinib, this observation suggests that the drug may cause severe rhabdomyolysis in a small propor
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... June 30, 2015 , ... Americans report feeling more stressed than ever ... mornings, which puts stressed out people right over the edge. , Almost half ... sleep deprivation every night. Sleeping pills now lead the list of the most prescribed ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... “It is ... founder of SunGrubbies.com. “We are particularly interested in getting the word out to ... years to surface. We are extremely pleased with our new video which ...
(Date:6/29/2015)... ... 30, 2015 , ... Aespala Medspa and Plastic Surgery is proud to introduce ... , Dr. Dreyfuss received his medical degree from Emory University in Atlanta before ... Plastic Surgery Fellowship at the University of Chicago. He has taught and practiced medicine ...
(Date:6/29/2015)... , ... June 30, 2015 , ... ... set of revised Guidelines for Neuro Musculoskeletal Thermography and Sympathetic Skin Response Studies.* ... Guidelines that were first published in 2006, are intended to aid physicians and ...
(Date:6/29/2015)... ... June 29, 2015 , ... Healthpointe, one ... Dr. John A. Mitamura, MD., PhD into their world-class multidisciplinary team of physicians ... Long Beach , Irwindale and La Tijera-Los Angeles. , Orthopedic surgeons ...
Breaking Medicine News(10 mins):Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 2Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 3Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Joins Effort to Promote Sun Safety 2Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Joins Effort to Promote Sun Safety 3Health News:Aespala Medspa and Plastic Surgery Welcomes New Plastic Surgeon to Oak Brook, IL Office 2Health News:Aespala Medspa and Plastic Surgery Welcomes New Plastic Surgeon to Oak Brook, IL Office 3Health News:American Academy of Thermology Publishes Revised 2015 Guidelines for Neuro-Musculoskeletal Thermography and Sympathetic Skin Response Studies 2Health News:American Academy of Thermology Publishes Revised 2015 Guidelines for Neuro-Musculoskeletal Thermography and Sympathetic Skin Response Studies 3Health News:Renowned Orthopedic and Spine Surgeon Joins Healthpointe in Long Beach 2Health News:Renowned Orthopedic and Spine Surgeon Joins Healthpointe in Long Beach 3
... projects require care and caution , , SUNDAY, March 29 (HealthDay ... yard work -- but if they,re not careful, it might ... with ladders, gardening tools and lawn mowers alone cause hundreds ... according to the U.S. Consumer Product Safety Commission. Many of ...
... produce better outcomes, study finds, , , SUNDAY, March 29 (HealthDay ... hoped would improve symptoms in people with heart failure ... , , The hope was that by isolating the damaged ... heart that pumps blood to the body -- people would ...
... for individuals who want to earn substantial income through sale of products ... Health has created a risk-free, hassle-free affiliate system with tremendous financial upsides. ... affiliate program. , ... New York (PRWEB) March 29, 2009 -- Looking ...
... rose after a defeat, and dropped after a victory , , ... team lose in the Super Bowl could actually end your ... is that a victory might do just the opposite, the ... College of Cardiology annual meeting, in Orlando, Fla. , To ...
... drug warfarin for many patients, researchers say, , , SATURDAY, ... soon replace the anti-clotting drug warfarin as the first ... a new study suggests. , People with atrial fibrillation ... noted, and typically need to take warfarin for the ...
... gestational age, being male did have a correlation , , ... affect the extent of head flattening in infants, U.S. ... severity of asymmetrical head shape, known as deformational plagiocephaly ... condition. , Since the early 1990s, parents have been ...
Cached Medicine News:Health News:Tips to Avoid Spring Cleaning Mishaps 2Health News:New Surgery for Heart Failure Proves Ineffective 2Health News:New Surgery for Heart Failure Proves Ineffective 3Health News:ZEO Health's New Program Offers Answer for Those Looking for Income 2Health News:Super Bowl Loss Can 'Kill' Some Fans 2Health News:New Device Treats Common Heart Rhythm Disorder 2Health News:New Device Treats Common Heart Rhythm Disorder 3Health News:Baby's Sleep Position May Not Affect Severity of Head Flattening 2
(Date:6/29/2015)... , June 29, 2015 BiondVax ... preliminary results from its BVX-006 Phase II clinical trial ... In this trial, M-001 was injected intramuscularly to volunteers ... an administration of the 2014/15 season trivalent influenza vaccine ... safe and well tolerated and induced humoral immune responses, ...
(Date:6/29/2015)... 2015  Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) ... Russell 1000 Index, effective June 26, 2015. The Russell ... of the U.S. equity universe. It is a subset ... of the largest securities based on a combination of ... "We are pleased to be added to this important ...
(Date:6/29/2015)... SAN JOSE, Calif. , June 29, 2015 ... its expert medical workstation lineup. The high-powered, multi-functional ... th generation Intel® Haswell Core ... processor. Both provide significant data processing and computing ... visual performance, making the unit well suited for ...
Breaking Medicine Technology:BiondVax Presents BVX-006 Preliminary Phase II Results: the Universal Flu Vaccine at Higher Doses is Safe and Improves Immunogenicity in Older Adults 2BiondVax Presents BVX-006 Preliminary Phase II Results: the Universal Flu Vaccine at Higher Doses is Safe and Improves Immunogenicity in Older Adults 3ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index 2ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index 3Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 2Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 3
... health,officials will honor residents of Framingham, Mass., Nov. 29, ... the thousands of,individuals who have participated in the landmark ... keynote speaker at an event in,Framingham honoring the participants, ... data from the study. This represents the first,time a ...
... Nov. 20 PAREXEL International,Corporation (Nasdaq: ... bio/pharmaceutical services,organization, has appointed Dr. Victor ... Pharmacoepidemiology within the Company,s Clinical Research,Services ... clients in,the design and conduct of ...
Cached Medicine Technology:Top Washington Health Officials to Honor Framingham Heart Study Participants 2PAREXEL Expands Late Phase Clinical Research Services and Appoints Leading Pharmacoepidemiology Expert Victor Kiri 2PAREXEL Expands Late Phase Clinical Research Services and Appoints Leading Pharmacoepidemiology Expert Victor Kiri 3PAREXEL Expands Late Phase Clinical Research Services and Appoints Leading Pharmacoepidemiology Expert Victor Kiri 4
... sophisticated Aumated Immunoassay Analyzer that fits in any ... 16 X 16 X 21 inches and weighs ... for physician office laboratories, work stations for small ... well as a dedicated system for specialty testing. ...
... ECi brings true automation and continuous ... Highly sensitive assays for thyroid, anemia, ... metabolism testing are currently available, with ... Vitros ECi can simultaneously process 60 ...
... the Therapeutic Drug Monitoring Market in 1981 ... in use today, this system uses technology ... measure serum drug concentration in a patient. ... different diseases, often exhibit a narrow therapeutic ...
Architect i2000 is a flexible solution for your evolving laboratory providing high throughput and walkaway time with built-in flexibility....
Medicine Products: