Navigation Links
Cancer Drug Gleevec Could Fight Stroke
Date:6/23/2008

It might extend the effectiveness of clot-busting tPA, researchers say

MONDAY, June 23 (HealthDay News) -- A powerful weapon against cancer might also boost stroke patients' survival, new research suggests.

Gleevec, long hailed as a "wonder drug" against cancers such as chronic myelogenous leukemia (CML), will be tested to see if it can boost the effectiveness and limit the side effects of the clot-dissolving drug tissue plasminogen activator (tPA), an international team of researchers say.

One of the ways that Gleevec stops the growth of cancer cells is to block receptors of platelet-derived growth factor-CC (PDGF-CC), explained Daniel Lawrence, professor of cardiovascular medicine at the University of Michigan and a member of the research team.

Studies performed at his lab, as well as at Sweden's Karolinska Institute, have both shown that blocking those receptors improves the activity of tPA.

Doctors typically give tPA in the hours after an ischemic stroke, which occurs when a blood clot blocks a brain artery. About 80 percent of all strokes are ischemic, and tPA is given to dissolve the clots.

But there's a big downside with the drug: It also can increase the odds for brain hemorrhage.

Reporting in the June 22 online edition of the journal Nature Medicine, the researchers at Karolinska and in Michigan showed for the first time that tPA increases the risk of bleeding by acting on PDGF-CC, as well as the cellular receptor to which it binds. This activity makes blood vessels in the brain dangerously leaky.

However, in other laboratory tests and in animal studies, Gleevec prevented this leakiness by blocking PDGF-CC receptors.

"Blocking the receptor reduces formation of edema -- swelling of the brain -- and so even in the absence of tPA, the [Gleevec] treatment would be beneficial," Lawrence pointed out.

But Gleevec might also extend tPA's usefulness, he added. "tPA loses its efficacy three hours after a stroke. Part of that loss may be an increase in major side effects, and the major side effect of tPA is bleeding," Lawrence explained. "You could conceivably block the receptor and give tPA beyond its current three-hour limit and still be effective at removing the blockage of a brain artery but reduce the complications."

Gleevec is not necessarily the perfect drug to achieve that effect, Lawrence said, because its activity on a number of other receptors could raise new concerns. "We are not currently testing any [other drug] in our laboratory, but any drug that blocks those receptors might possibly be even better than Gleevec," he said. "One could develop even more specific receptor blockers."

A first human trial, primarily to test the safety of the proposed treatment, will soon begin in Sweden, said Ulf Eriksson, professor of molecular biology at the Karolinska Institute, one of the leaders of the research effort. It will be done by physicians at the Karolinska Institute Hospital in Stockholm.

The trial is planned to include 60 people who will be treated in the hours after they suffer strokes. Some will be given Gleevec within three hours of the stroke in addition to standard tPA treatment. Others whose treatment started later for one reason or another will be given Gleevec in addition to tPA after the three-hour period desired for such treatment. Their results will be compared to similar stroke patients given standard treatment.

Results of that study should be available "within one year," Eriksson said. Plans for future human trials would depend on those results, he said.

More information

There's more on tPA and other stroke therapies at the American Heart Association.



SOURCES: Daniel Lawrence, Ph.D., professor, cardiovascular medicine, University of Michigan, Ann Arbor; Ulf Eriksson, Ph.D., professor, molecular biology, Karolinska Institute, Stockhold, Sweden; June, 22, 2008, online edition, Nature Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Symptoms Plus Blood Test Boost Ovarian Cancer Detection
2. Symptom screening plus a simple blood test improves early detection of ovarian cancer
3. Risk of death after cancer diagnosis; shift in stage of breast cancer diagnosis
4. Honor a Loved One at The American Cancer Societys Relay for Life
5. Damon Runyon Cancer Research Foundation awards $2.25M to 5 top young clinical investigators
6. CT Screens for Lung Cancer Not a Cure-All
7. Pro Baseball Helps Keep Skin Cancer From Scoring
8. Quest Diagnostics to Provide Diagnostic Testing Services for the Women of Ireland through Irelands First Nationwide Cervical-Cancer Screening Program
9. American Academy of Dermatology, Major League Baseball and Major League Baseball Players Association Play Sun Smart(TM) to Strike Out Skin Cancer
10. Lack of CHFR gene expression sets stage for breast cancer
11. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Drug Gleevec Could Fight Stroke
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Surgical Procedure Volumes: Global Analysis (United States, China, Japan, ... report to their offering. ... tool for healthcare business planners, provides surgical procedure volume ... surgery trends with an in-depth analysis of growth drivers ...
Breaking Medicine Technology: