Navigation Links
Cancer Cells May Be Able to Urge Their Own Death
Date:12/22/2010

WEDNESDAY, Dec. 22 (HealthDay News) -- New research suggests that many cancer cells are equipped with a kind of suicide pill: a protein on their surfaces that gives them the ability to send an "eat me" signal to immune cells.

The challenge now, the researchers say, is to figure out how to coax cancer cells into emitting the signal rather than a dangerous "don't eat me" signal.

A study published online Dec. 22 in Science Translational Medicine reports that the cells send out the enticing "eat me" signal by displaying the protein calreticulin. But another molecule, called CD47, allows most cancer cells to avoid destruction by sending the opposite signal: "Don't eat me."

In earlier research, Stanford University School of Medicine scientists found that an antibody that blocks CD47 -- turning off the signal -- could help fight cancer, but mysteries remained.

"Many normal cells in the body have CD47, and yet those cells are not affected by the anti-CD47 antibody," Mark Chao, a Stanford graduate student and the study's lead author, said in a university news release. "At that time, we knew that anti-CD47 antibody treatment selectively killed only cancer cells without being toxic to most normal cells, although we didn't know why."

Now, the new research has shown that calreticulin exists in a variety of cancers, including some types of leukemia, non-Hodgkin's lymphoma and bladder, brain and ovarian cancers. "This research demonstrates that the reason that blocking the CD47 'don't eat me' signal works to kill cancer is that leukemias, lymphomas and many solid tumors also display a calreticulin 'eat me' signal," Dr. Irving Weissman, director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and a co-principal investigator of the study, said in the release. "The research also shows that most normal cell populations don't display calreticulin and are, therefore, not depleted when we expose them to a blocking anti-CD47 antibody."

The next step is to understand how calreticulin works. "We want to know how it contributes to the disease process and what is happening in the cell that causes the protein to move to the cell surface," Dr. Ravindra Majeti, an assistant professor of hematology and study co-principal investigator, said in the release.

"Any of these mechanisms offer potential new ways to treat the disease by interfering with those processes," Majeti said.

More information

The American Cancer Society has more on cancer.

-- Randy Dotinga

SOURCE: Stanford University School of Medicine, news release, Dec. 22, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Cells May Be Able to Urge Their Own Death
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... provider of comprehensive treatment for eating disorders, is opening a brand new child ... provide individuals ages 8-17 and their families with even more specialized eating disorder ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... of Mehling Orthopedics and chief medical officer of Blue Horizon International (BHI), Brian ... Regeneration. The conference was held during May 5-6, 2016 in Chicago, IL, USA. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Bunion Bootie , the manufacturer of the ... more than humbled by customer demand over the Mother’s Day Weekend promotion. So much ... that Bunion Bootie has completely replenished its inventory levels, it hopes to continue its ...
(Date:5/26/2016)... ... 26, 2016 , ... The introduction of our professional athletes coincides with the ... , “We are proud to introduce Meghan Klingenberg, defender and World Champion ... Quick, wide receiver for Los Angeles who was a second round selection in the ...
(Date:5/26/2016)... ... May 26, 2016 , ... May 2016 – Lips ... central to popular cosmetic improvement efforts. Record numbers of clients now ask about lip ... or pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , The ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016 A key trend ... the emergence of new treatments. Cardax, a development stage ... treatment. The therapy is expected to fulfil large unmet ... is conducting studies to develop new treatments for osteoarthritis. ... genes involved in osteoarthritis are being investigated, and early ...
(Date:5/26/2016)... , May 26, 2016   Change ... and analytics, network solutions and technology-enabled services ... it entered into a strategic channel partnership ... outpatient software solutions and revenue cycle management ... hospitals and rehabilitation clinics to optimize revenue, ...
(Date:5/25/2016)... PARIS , May 25,2016 ... with the near-infrared Cellvizio platform for urological and ... MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary ... important regulatory milestone in the US with the ... Food and Drug Administration (FDA). This new FDA ...
Breaking Medicine Technology: