Navigation Links
Cancer-Causing Gene Discovery Suggests New Therapies
Date:1/23/2009

how the oncogene affected the subsequent production of proteins, a step known as translation, was unknown.

"A cancer causing gene, such as Myc, regulates many distinct cellular processes, and that can make it very difficult to tease apart which ones are the most important for the cancer to progress," says Barna, a faculty fellow in the UCSF biochemistry and biophysics department. "The key to our studies was the ability to generate novel genetic tools to halt Myc's action on protein production. This demonstrates how essential this process is for cancer formation."

To test whether protein production induced by Myc played a role in cancer, the UCSF- led team genetically crossed two types of mice: one that was cancer-prone and overexpressed the Myc oncogene and one that was newly engineered to lower protein production. The new cross of mice possessed not only the well-known destructive Myc traits, but also an enhanced ability to damp down protein production.

In these mice, the restrained protein production restored to near-normal the cell growth, division and protective cell-sacrifice needed to counter cancer.

The scientists also found that this increased control over the so-called "translation" of RNA into proteins countered damage to chromosome function otherwise caused by Myc, and preserved functions vital to faithful cell division. Changes in the genetic integrity of cells are recognized as hallmarks of cancer, and the new findings show that Myc can cause these abnormalities through control of protein production.

The research suggests that Myc may disrupt a number of genes "downstream" of its damage to DNA, the scientists say.

"We discovered a previously unrecognized link between alterations in protein synthesis and the mechanism by which cells maintain the integrity of the genome," Ruggero stresses. "We found that when Myc is overexpressed, this leads
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
2. Zassi Medical Evolutions Launches New Online Company That Uses Business DNA to Deliver Advanced Discovery, Collaboration, and Business Intelligence Tools to the Medical Device Industry
3. American Asthma Foundation Announces Breakthrough Discovery
4. Life Sciences Discovery awards health research program grants
5. MaxCyte Presents a Panel Discussion With Industry Experts on the Challenges in Developing Cell-Based Screening Assays for Drug Discovery - LIVE Q&A to Follow
6. Exciting discovery could stop cancer from killing people
7. Discovery Healths NATIONAL BODY CHALLENGE Weighs in for a Sixth Season, Urging Americans to Break up With Bad Habits
8. Surprise discovery made in cancer research
9. Med school discovery could lead to better cancer diagnosis, drugs
10. Purdue Pharma L.P. Announces a Global Strategic Alliance With Infinity Pharmaceuticals to Advance Discovery and Development Programs in Oncology and Neuropathic Pain
11. Leeds researchers reshape the future of drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-Causing Gene Discovery Suggests New Therapies
(Date:8/27/2014)... New York, New York (PRWEB) August 27, 2014 ... to be filed in U.S. courts on behalf of ... due to uterine morcellation, Bernstein Liebhard LLP reports. According ... was filed on August 18th in the U.S. District ... a hysterectomy patient who claims the use of a ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 Picture, if ... not Holmes and Watson but more of a Mr. Inside, ... Davis, in terms of personalities and world view. This Mr. ... University of Texas at Austin, and Mr. Outside was an ... family physician, his new girlfriend, and a gaggle of teenagers ...
(Date:8/27/2014)... When Jagger was 20 years old and at ... that he credits as one of the most memorable phone ... she could set him up with a summer job; one ... that job, and he has now spent the past 22 ... he also worked in school boards, employment programs and youth ...
(Date:8/27/2014)... Abington, PA (PRWEB) August 27, 2014 ... Lower Gwynedd, PA on Monday, September 8, 2014. This ... outpatient campus that features three primary care practices and ... outpatient facility is a very exciting endeavor for Abington ... Merlis, president and CEO, Abington Health. “Establishing a location ...
(Date:8/27/2014)... Amy Norton HealthDay Reporter ... take part in clinical trials of new heart disease treatments ... a new study confirms. Experts said the findings, which ... Medical Association , aren,t surprising -- but they are troubling. ... a more select patient population that is not fully representative ...
Breaking Medicine News(10 mins):Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 4Health News:UW Rankin Self-Publishes Debut Novel, Sublimity: Perchance to Dream, A Speculative Science Mystery 2Health News:Fitness on the Go Expands into Liberty Village, City Place and Harbourfront Communities 2Health News:Fitness on the Go Expands into Liberty Village, City Place and Harbourfront Communities 3Health News:Fitness on the Go Expands into Liberty Village, City Place and Harbourfront Communities 4Health News:Abington Health Opens New Health Center in Lower Gwynedd 2Health News:Heart Studies Don't Reflect Real-World Patients, Study Finds 2Health News:Heart Studies Don't Reflect Real-World Patients, Study Finds 3
... for ... health plans, WOONSOCKET, R.I., June ... Health Insurance Plans,(AHIP) Institute 2008 to be held June 18-20, 2008 in ... Consumer,Experience" will discuss ways in which health plans can take a proactive,approach ...
... Cardo Medical,LLC, a company engaged in the ... Bulletin Board: CKST), a publicly-traded,company with no active ... Cardo Medical will become a wholly owned subsidiary ... be renamed,Cardo Medical, Inc., and will be headquartered ...
... League Baseball(TM) to raise awareness of, Benign Prostatic Hyperplasia (BPH), ... ... N.J., June 19 Hall of Fame third,baseman and Philadelphia Phillies legend ... Game Plan Starts with U:,Catch the Whole Game campaign, a program in ...
... Calif., and PHILADELPHIA, June 19 /PRNewswire-FirstCall/,-- Cord ... the umbilical cord,blood stem cell preservation company ... life saving potential of stem cells to ... joined New York,and California in enacting legislation ...
... study of identical twins has found that physical inactivity ... which help the cells produce energy. The findings suggest ... in people who are obese. Insulin resistance increases the ... study, "Acquired obesity and poor physical fitness impair expression ...
... Lab,Internacional, S.A.B. de C.V. (BMV: LAB) ("Genomma" or ... public offering. The offering,consisted of 130,869,566 series B ... was placed with Mexican investors., (Logo: ... 23.1% of the total offering size is,being sold ...
Cached Medicine News:Health News:CVS Caremark to Present Insights on Redefining the Consumer Health Care Experience at AHIP Institute 2008 2Health News:CVS Caremark to Present Insights on Redefining the Consumer Health Care Experience at AHIP Institute 2008 3Health News:clickNsettle.com, Inc. and Cardo Medical, LLC Announce Merger Agreement 2Health News:clickNsettle.com, Inc. and Cardo Medical, LLC Announce Merger Agreement 3Health News:Hall of Fame Baseball Legend Mike Schmidt Speaks Out for the First Time About Common Health Problem in Older Men 2Health News:Hall of Fame Baseball Legend Mike Schmidt Speaks Out for the First Time About Common Health Problem in Older Men 3Health News:Hall of Fame Baseball Legend Mike Schmidt Speaks Out for the First Time About Common Health Problem in Older Men 4Health News:Hall of Fame Baseball Legend Mike Schmidt Speaks Out for the First Time About Common Health Problem in Older Men 5Health News:Cord Blood America Says Pennsylvania Joins New York and California in Informing Parents of the Advantages of Umbilical Cord Blood Storage 2Health News:Lifestyle can alter gene activity, lead to insulin resistance 2Health News:Lifestyle can alter gene activity, lead to insulin resistance 3Health News:Genomma Lab Prices Initial Public Offering and Begins Trading on Mexican Stock Exchange 2
(Date:8/27/2014)... MISSISSAUGA, ON , Aug. 27, 2014 /CNW/ - Covalon ... medical technologies company, announces the following financial results for its ... months ended June 30, 2014: , Revenue of ... prior year , Net loss for the quarter of ... period of the prior year For the ...
(Date:8/27/2014)... SAN DIEGO , Aug. 27, 2014 Ambit ... discovery and development of drugs targeting unmet needs in oncology, ... the Baird 2014 Health Care Conference to be held at ... City on September 3-4, 2014. ... the Company and its lead drug candidate, quizartinib, at 1:10 ...
(Date:8/27/2014)... PASADENA, Calif. , Aug. 27, 2014  After ... Compensation and Personal Injury billing solution for medical ... extremely positive response toward the new software. ... Development Sandy Thompson . "The sheer number of ... how true the need was for these types of ...
Breaking Medicine Technology:Covalon Announces Third Quarter Results 2Covalon Announces Third Quarter Results 3Ambit Announces Participation At Baird 2014 Health Care Conference 2Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 2Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 3
... July 20, 2011 The National Operating Committee on ... Disease Control and Prevention (CDC) are teaming up to ... designed specifically to provide parents with the facts about ... high school athlete concussions. The partnership, made possible by ...
... Minimally Invasive Devices, Inc. , (MID) has ... ™ laparoscopic visualization system.  This certification is mandatory for ...   The FloShield system provides for an ... from the insufflator to defog and deflect debris from ...
Cached Medicine Technology:NOCSAE, CDC Team Up to Give "Heads Up to Parents" About Concussions in Youth Sports 2NOCSAE, CDC Team Up to Give "Heads Up to Parents" About Concussions in Youth Sports 3NOCSAE, CDC Team Up to Give "Heads Up to Parents" About Concussions in Youth Sports 4Minimally Invasive Devices, Inc. Awarded CE Mark for FloShield™ 2
Developed in conjunction with Pierce E. Scranton, Jr., M.D., the Seattle Small Joint Arthroscopy Set offers meticulously designed instrumentation for elbow, foot, and ankle surgeries....
Developed in conjunction with Pierce E. Scranton, Jr., M.D., the Seattle Small Joint Arthroscopy Set offers meticulously designed instrumentation for elbow, foot, and ankle surgeries....
... ECTRA II systems permit the surgeon to ... endoscopically, allowing access via two portals for ... lens fogging with good air flow. ECTRA ... control. ECTRA knives permit the surgeon to ...
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
Medicine Products: