Navigation Links
Cancer-Causing Gene Discovery Suggests New Therapies
Date:1/23/2009

how the oncogene affected the subsequent production of proteins, a step known as translation, was unknown.

"A cancer causing gene, such as Myc, regulates many distinct cellular processes, and that can make it very difficult to tease apart which ones are the most important for the cancer to progress," says Barna, a faculty fellow in the UCSF biochemistry and biophysics department. "The key to our studies was the ability to generate novel genetic tools to halt Myc's action on protein production. This demonstrates how essential this process is for cancer formation."

To test whether protein production induced by Myc played a role in cancer, the UCSF- led team genetically crossed two types of mice: one that was cancer-prone and overexpressed the Myc oncogene and one that was newly engineered to lower protein production. The new cross of mice possessed not only the well-known destructive Myc traits, but also an enhanced ability to damp down protein production.

In these mice, the restrained protein production restored to near-normal the cell growth, division and protective cell-sacrifice needed to counter cancer.

The scientists also found that this increased control over the so-called "translation" of RNA into proteins countered damage to chromosome function otherwise caused by Myc, and preserved functions vital to faithful cell division. Changes in the genetic integrity of cells are recognized as hallmarks of cancer, and the new findings show that Myc can cause these abnormalities through control of protein production.

The research suggests that Myc may disrupt a number of genes "downstream" of its damage to DNA, the scientists say.

"We discovered a previously unrecognized link between alterations in protein synthesis and the mechanism by which cells maintain the integrity of the genome," Ruggero stresses. "We found that when Myc is overexpressed, this leads
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
2. Zassi Medical Evolutions Launches New Online Company That Uses Business DNA to Deliver Advanced Discovery, Collaboration, and Business Intelligence Tools to the Medical Device Industry
3. American Asthma Foundation Announces Breakthrough Discovery
4. Life Sciences Discovery awards health research program grants
5. MaxCyte Presents a Panel Discussion With Industry Experts on the Challenges in Developing Cell-Based Screening Assays for Drug Discovery - LIVE Q&A to Follow
6. Exciting discovery could stop cancer from killing people
7. Discovery Healths NATIONAL BODY CHALLENGE Weighs in for a Sixth Season, Urging Americans to Break up With Bad Habits
8. Surprise discovery made in cancer research
9. Med school discovery could lead to better cancer diagnosis, drugs
10. Purdue Pharma L.P. Announces a Global Strategic Alliance With Infinity Pharmaceuticals to Advance Discovery and Development Programs in Oncology and Neuropathic Pain
11. Leeds researchers reshape the future of drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-Causing Gene Discovery Suggests New Therapies
(Date:12/19/2014)... drug users who also use cocaine and amphetamines have ... users, a new study finds. "We know that ... attempt and completed suicide," Didier Jutras-Aswad, a psychiatry professor ... news release. "However, there are many different profiles of ... users were actually more likely to attempt suicide." ...
(Date:12/19/2014)... Dec. 19, 2014 (HealthDay News) -- The cost of ... well-being, a new study finds. Researchers examined data ... been diagnosed with colorectal or lung cancer. Of those ... cancer-free, and more than 100 had advanced cancer. ... to pay their medical bills, which was linked with ...
(Date:12/19/2014)... NC (PRWEB) December 19, 2014 Surviving Mesothelioma ... and EPA information indicates that these pipes can leach asbestos ... go to the full story on the Surviving Mesothelioma ... the erosion of natural asbestos deposits, decaying water mains made ... drinking water. , To protect consumers from mesothelioma ...
(Date:12/19/2014)... Dennis Thompson HealthDay ... -- Ebola,s entrance into the United States -- along ... mumps outbreak -- have highlighted cracks in the nation,s ... new health policy report released Thursday. Half of ... respond to infectious disease outbreaks. That was the main ...
(Date:12/19/2014)... B. E. Smith, the only full-service leadership ... retained to lead a national chief financial officer ... The top executive search firm in the healthcare industry, ... healthcare executives into organizations. , Johnson Memorial Hospital ... to the residents of Johnson County and the surrounding ...
Breaking Medicine News(10 mins):Health News:Cocaine, Amphetamines May Up Injection Drug Users' Suicide Risk 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Surviving Mesothelioma Warns of Potential Mesothelioma Risk from Cement Water Pipes 2Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 2Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 3Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 4Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3
... benefits which could run parallel to that of penicillin ... of Medicine at Harvard Medical School. ,Professor ... levels in unrefined cocoa has the potential to combat ... world viz. stroke, heart ailments, cancer and diabetes. He ...
... German scientists have found that the scent of ... The scientists at the University of Lubeck, ... programmed bursts of rose odors, while they were memorizing cards ... sent off to sleep with electrodes connected to their heads. ...
... Hopkins emergency medicine specialists have developed a tool ... potential to overwhelm services//. ,The Electronic Mass ... calculates the impact of such crises as a ... accounting for such elements as numbers of victims, ...
... including those with a family history of the disease, should ... to prevent the disease. ,This is the first ... taking medicines to prevent colorectal cancer. After reviewing the latest ... potential harms of taking more than 300 mg per day ...
... who devote more time to physical activity have a ... next 15 years, according to new research// . ... physical activity is actually causally related to hypertension,” said ... an epidemiologist at the University of Minnesota in Minneapolis, ...
... conducted on mice shows that more copper in everyday ... was conducted by scientists at the University of Louisville ... ,Their studies show that giving copper supplements ... by preventing heart enlargement. The study will be published ...
Cached Medicine News:Health News:Scent of a Rose may Give More Than Pleasure 2Health News:Aspirin Or NSAIDs Will not Prevent Colorectal Cancer 2Health News:Physical Activity Reduces Hypertension Risk in Young Adults 2
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between dropping ... health was forgotten. But Audicus , a next-generation ... better this new year. Hearing loss is ... aging population, though it is often unaddressed. Forty-eight million ... has a hearing aid, mainly due to price. Hearing ...
(Date:12/19/2014)... 18, 2014  Sage Analytics ( www.sageanalytics.com ), ... for the testing of marijuana potency and moisture ... Luminary™ Profiler, the industry,s first product suite capable ... cost-effective, portable unit. Designed from the ... the cannabis industry, the Luminary™ Profiler utilizes specially ...
(Date:12/19/2014)... Dec. 18, 2014 Capnia, Inc. (NASDAQ: ... of medical diagnostics based on its proprietary Sensalyze™ ... today announced financial results for the third quarter ... "Following the completion of our initial public ... maximize the recently initiated CoSense® commercial launch," said ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8
... Jan. 6, 2011 /PRNewswire-Asia-FirstCall/ -- Nutrastar International Inc. (OTC ... "Company"), a leading producer and supplier of premium branded ... the Company will be participating in the upcoming Cowen ... the Westin New York at Times Square (270 West ...
... 2011 Viveve, Inc. , a development stage ... the European CE (Conformite Europeenne) mark for the use ... laxity of the vaginal introitus (opening), after childbirth, to ... ) "The CE mark is a key ...
Cached Medicine Technology:Nutrastar to Present at the Cowen and Company 9th Annual Consumer Conference in NYC 2Nutrastar to Present at the Cowen and Company 9th Annual Consumer Conference in NYC 3Viveve Obtains CE Mark for Gynecologic Treatment of Vaginal Laxity 2
Gentle-Flo® Vactrol® Connector., ,Indications For Usage: ,Removal of secretions from respiratory tract....
... 8 Suction Catheters With Contro-Vac Valve and ... Low-Risk Respiratory Suctioning, ,Medline's 6 and ... DeLee Tips are the optimal tools for ... a forward placed suction valve to minimize ...
... available in two tip styles- ... with staggered eyes, and the ... of catheter valve options, SAFE-T-VAC ... control with virtually no residual ...
... Our Tri-Flo® suction catheter design ... to your patients while still providing ... pediatric catheters (5/6, 8 or 10 ... facilitate proper catheter placement. Our complete ...
Medicine Products: