Navigation Links
Cancer: Tumors absorb sugar for mobility
Date:7/28/2014

Cancer cells are gluttons. We have long known that they monopolize large amounts of sugar. More recently, it became clear that some tumor cells are also characterized by a series of features such as mobility or unlikeliness to join in an ordered set. Researchers are calling this behavior "mesenchymal," and they suspect it promotes metastasis.

At EPFL, Etienne Meylan's research team was able to demonstrate that the two observations appetite for sugar and mesenchymal behavior result from the same mechanism, at least in "non-small cell lung cancer." They also showed that the intensity of the phenomenon significantly influenced the chances of patient survival. Published in Cancer & Metabolism, this discovery opens up new potential targets for future therapies.

A useful mechanism, but put to work by cancer

Mesenchymal behavior is not in itself an anomaly. During embryonic development, some cells acquire these characteristics. In adults, a few cells retain this disposition.

"Mesenchymal behavior is a quite useful feature, but is abnormally reactivated in non-small cell lung cancer, which we studied," says Etienne Meylan.

The mesenchymal cancer cells studied by the researchers produce a protein called GLUT3. The latter serves the function of capturing glucose to activate various growth processes. This is the protein responsible for meeting the cell's need for sugar.

By artificially inducing mesenchymal behavior in cancer cells, the researchers found that the cells spontaneously produced GLUT3. This observation clearly shows that the same mechanism is at work. "This shift from one behavior to another, called epithelial-mesenchymal transition, is a highly debated issue. We have clearly established a cause and effect relationship between this transition and the glucose consumption of cancer cells," explains Mark Masin, lead author and PhD student at EPFL.

A case study confirms the results

Lung tumor cells produce widely varying amounts of GLUT3. This is because the gene is itself regulated by an element called ZEB1, and the amount of the latter is a function of many causes.

These variations in the amounts of GLUT3 seem to be a strong indicator of the aggressiveness of the tumor. By analyzing data from 450 patients with metastatic non-small cell lung cancer, researchers were able to show that the larger the quantity of GLUT3, the lower the chances of survival.

Patients were diagnosed relatively early and were followed for several years. Depending on whether they produced high or low amounts of GLUT3, their survival rates over seven years spanned almost 20%. "Our data don't permit us to conclude that the mechanism promotes metastasis, but it reinforces the assumption," says Mark Masin.

The discovery identifies a potential target for future medications. Etienne Meylan imagines, for example, a toxic molecule that could be specifically incorporated by GLUT3 to destroy the cell from within. "Protected by the blood-brain barrier, neurons that also produce GLUT3 would not be affected," says the researcher.


'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Related medicine news :

1. Hormones after breast cancer: Not fuel for the fire after all?
2. Genetics of cancer: Non-coding DNA can finally be decoded
3. Technique Used in Some Hysterectomies May Help Spread Cancer: Study
4. Breast cancer: DMP is largely consistent with guidelines
5. Capturing cancer: A powerful new technique for early diagnosis
6. Cancer: The roots of evil go deep in time
7. Advanced breast cancer: Benefits of Trastuzumab (Herceptin) outweigh the risk of harm
8. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
9. Enzalutamide in prostate cancer: Hints of added benefit
10. Vandetanib in thyroid cancer: Added benefit not proven
11. Cosmetics and Beauty Products Could Cause Cancer: New Website Explores Evidence Online
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, ... the beginning of the latest charity campaign in their community enrichment program. Art ... to this worthy cause are currently being accepted at: http://artexpressioninc.org/ . , ...
(Date:2/12/2016)... ... February 12, 2016 , ... J Thomas & Associates ... it’s commitment to act as Agents of Change in the community, announces a ... homeless families to fulfill immediate needs and help them move into permanent housing. ...
(Date:2/12/2016)... Pa. (PRWEB) , ... February 12, 2016 , ... ... sort through a world of exterior design possibilities. CertainTeed, North America’s leading brand ... tools by expanding the product offerings showcased in the mobile version of the ...
(Date:2/12/2016)... SAN LUIS OBISPO, Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast ... purpose of this dance is to provide a night of fun for teens with and ... to help everyone feel welcomed and included at the event. The dance will take place ...
(Date:2/12/2016)... CA (PRWEB) , ... February 12, 2016 , ... ... Film Studios. The new cartoon style themes are great for showcasing pictures, videos as ... customized scene generators, titles like introductions, lower thirds, transitions and a beautiful frame overlay. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016 AAIPharma Services Corp./Cambridge Major Laboratories, ... and development services for the pharmaceutical and biotechnology ... capacity in its Charleston, SC ... several recent investments. Charleston ... line with small-scale lyophilization. The site has invested ...
(Date:2/11/2016)... ANKENY, Iowa , 11 de fevereiro de ... a inauguração de sua fábrica de soroalbumina bovina ... Nova Zelândia. A fábrica fica na Ilha Norte ... Loop "), desenvolvido e estabelecido na fábrica da ... Iowa . O projeto e instalação dos ...
(Date:2/11/2016)... Breast Cancer Therapeutics in Asia-Pacific Markets ... (APAC) breast cancer market will experience considerable expansion ... at a Compound Annual Growth Rate (CAGR) of 8.5%. ... - states that the Asia-Pacific ... billion in 2014 to $3.4 billion by 2021, at a ...
Breaking Medicine Technology: