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Canary Foundation and American Cancer Society Award Five Postdoctoral Fellowships in Early Cancer Detection
Date:6/12/2008

signatures associated with early and late stages of

prostate cancer, and identify the mechanisms driving ncRNA expression.

This project will have a broad significance by establishing an

integrative approach for ncRNA discovery which can be applied to a

variety of cancers. Comparison of the results may illustrate patterns

of protease activity in specific types of cancer or individual protease

substrates as biomarkers, which would provide a basis for further

clinical development.

-- Michael Pluth -- Massachusetts Institute of Technology

Dr. Pluth's study hopes to design and develop reversible fluorescent

sensors for nitric oxide (NO) by using iron for use in live cells for

the detection and quantification of intracellular levels of NO. NO has

shown to play an active role in biological signaling and current

sensors prohibit real-time quantification of nitric oxide

concentrations. This study will further the understanding of the

unique dichotomous role of nitric oxide in carcinogenesis and tumor

growth prevention, and will ideally contribute to the long-term goal of

developing new, non-invasive strategies for the early detection of

cancer.

-- Joe Shuga -- University of California, Berkeley

Using microfluidic technologies developed by the U.C. Berkeley's

Mathies lab, Dr. Shuga seeks to conduct single cell genetic analysis of

several genes parallel in individual human cells. By sequencing genes

from single cells, it will be possible to detect key mutations in rare

cells such as normal or cancer stem cells. The ability to sequence

genes linked to cancer in single cells will aid in early detection of

biomarkers, monitoring of minimal residual disease, and understanding

cancer etiology.

-- Robert W. Sprung -- Vanderbilt Ingram Canc
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SOURCE Canary Foundation
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