Navigation Links
Canadian scientists link fat hormone to death from potentially deadly blood infection
Date:10/23/2009

A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsisan overwhelming infection of the blood which claims thousands of lives each year.

The study by researchers at St. Michael's Hospital and the University of Toronto focused on adiponectin, a hormone secreted by visceral fat surrounding the abdominal organs. The findings were presented this week at the 2009 Clinical Congress of the American College of Surgeons held in Chicago.

Using an animal model designed to mimic what occurs in people with low levels of adiponectin, the scientists observed that:

o Mice with low levels of the hormone were at much greater risk of dying from a blood infection. o Sepsis could be prevented if the animals were given additional adiponectin.

The risk of dying from sepsis after surgery is known to be two-and-a-half to three times higher in people with "metabolic syndrome"a combination of factors including abdominal obesity, high blood fat composition, high blood pressure, diabetes, and high inflammatory and blood clot indicators. People with these conditions tend to have lower levels of adiponectin which may prime them to greater sepsis related complications.

"We hypothesized that low adiponectin levels might predispose such individuals to develop sepsis and sepsis-related problems," says Dr. Subodh Verma, a cardiac surgeon at St. Michael's Hospital and associate professor of surgery at the University of Toronto who holds the Canada Research Chair in Atherosclerosis. "This initial hypothesis was borne out by our latest research."

Dr. Verma and his colleagues believe the implications of their study are two-fold: first, low adiponectin levels may help predict which patients are vulnerable to sepsis-related inflammation and are at a greater risk of dying from sepsis; second, treatment strategies or approaches that cause an increase in adiponectin levels may lower a person's risk of death from severe sepsis.

Any discovery that might help predict or prevent sepsis-related death would be welcome, Dr. Verma adds, particularly since in certain parts of North America, 40 to 50 percent of the population has the major risk factors of metabolic syndrome. "We need treatments that are going to be effective and hopefully, reduce mortality rates in this high-risk population," he says.

Dr. Verma and his colleagues are hoping to be the first group to conduct studies of adiponectin in humans. They are currently seeking approval to mount a small clinical trial where a purified form of adiponectin will be given to patients in the early stages of sepsis. If the treatment is found to be safe, a larger trial may follow, says Dr. Verma.


'/>"/>

Contact: Julie Saccone
sacconej@smh.toronto.on.ca
416-864-5047
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. Canadian Cardiovascular Society recognizes trailblazing work by U of Alberta heart researcher
2. Researcher, physician and teacher Phil Gold to be inducted into the Canadian Medical Hall of Fame
3. Canadian blood supply future uncertain as population ages: Study
4. Canadian researchers discover the first-ever link between intelligence and curiosity
5. Queens study to test Canadian guidelines for daily exercise
6. Elsevier and Canadian College of Health Service Executives announce new publishing partnership
7. NeuroVasx Receives Canadian Approval for cPAX Aneurysm Treatment System
8. Canadians Travel to Detroit Town Meeting to Talk About Their Health Care
9. The National Health Care Anti-Fraud Association Signs Memorandum of Understanding With Canadian and European Anti-Fraud Organizations
10. Narconon Trois-Rivieres Cites Hillbilly Heroin as Canadian Drug Addiction Crisis
11. Canadian Bio Med Attacks Worlds Leading Cause of Blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
Breaking Medicine Technology: