Navigation Links
Canadian researchers find potential new leukemia treatment with old antibiotic drug
Date:11/14/2011

(Toronto Nov. 14, 2011) Clinician-scientists in the Princess Margaret Cancer Program have found a promising approach to treating leukemia, using an old drug in a new way.

The proof-of-concept research published today in Cancer Cell (10.1016/j.ccr.2011.10.015) describes how the Canadian team discovered that the antibiotic tigecycline targets and destroys leukemia stem cells by cutting off the cell's energy production.

"If you think of all the cells in the body as a power grid, we've discovered that tigecycline can cause a power outage in leukemia stem cells, while still keeping the lights on in all the healthy cells," says Dr. Aaron Schimmer, clinician-scientist at the Campbell Family Institute for Cancer Research in the Princess Margaret Cancer Program, University Health Network. He is also an associate professor in the departments of medicine, medical biophysics, and Institute of Medical Science at the University of Toronto (U of T).

To identify known drugs with previously unrecognized ability to kill leukemia cells and leukemia stem cells, the scientific team amassed a library of hundreds of known drugs to try, including tigecycline an intravenous antibiotic normally used to treat skin and abdominal infections. A high-speed, pipette-handling robot tested varying doses of each drug to see if any affected leukemia cells.

"Technology made this discovery possible. In three days, we found which potential leukemia drugs might be hiding in plain sight," says Dr. Schimmer. "Sifting through every combination by hand would have taken months."

"We tested more than 500 existing drugs on leukemia. Of the handful that made an impact, tigecycline was the most potent and revealed novel insights into the biology of leukemia at a cellular level," says lead author, Marko krtić, an MD/PhD student in the Faculty of Medicine at U of T, completing his PhD studies in Dr. Schimmer's lab.

The Canadian team demonstrated that leukemia cells have unique energy requirements and it is possible to selectively shut down this energy production in leukemia cells by blocking protein synthesis in the mitochondria.

By looking for new treatments in approved drugs, cancer researchers may be able to rapidly test these new strategies in patients, says Dr. Schimmer, who is now beginning multi-centre clinical trials with tigecycline as a treatment for leukemia.


'/>"/>

Contact: Geoff Koehler
geoff.koehler@uhn.ca
416-340-4011
University Health Network
Source:Eurekalert

Related medicine news :

1. Heart transplant surgery safe and effective: A Canadian retrospective spanning 3 decades
2. Canadian Journal of Cardiology publishes report on delayed vs. immediate coronary stenting
3. How hemp got high: Canadian scientists map the cannabis genome
4. Fatal crashes in the US: Fewer Canadian drivers under the influence
5. Skin color matters when it comes to Canadians health: UBC study
6. Most Canadians can be uniquely identified from their date of birth and postal code
7. US physician practices spend 4 times Canadian practices
8. US physicians spend nearly 4 times more on health insurance costs than Canadian counterparts
9. New Canadian blood pressure education program a powerful tool in fight to reduce stroke
10. Medicare improved Canadian doctors salaries: Queens University study
11. Canadians should demand commitments for pharmacare program, says CMAJ
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... In an article published ... her enthusiasm for Botox and lip injections, which she underwent in order to feel ... Valley Music and Arts Festival. The article explains that Ms. Mirmelli’s situation is not ...
(Date:4/29/2016)... ... April 29, 2016 , ... On Tuesday, April 26, 2016 members ... celebrated the signature of Gov. Nathan Deal on SB 258, the “Rural Health Care ... Cumming), offers a 70% tax credit to individuals and corporations which donate directly to ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Coast Dental ... 16, 2016, at its new location in the Exchange Furniture Mall at 112 Vilseck ... for a 50-inch Samsung Smart TV. Plus attendees will have the opportunity to meet ...
(Date:4/29/2016)... ... April 29, 2016 , ... World Patent ... Gyrociser, an exercise invention which aids in proper muscle development. , "The Gym ... and Creative Director of World Patent Marketing. "Globalization has threatened the future growth ...
(Date:4/29/2016)... ... April 29, 2016 , ... Reltok Nasal Products proudly ... for the head and neck/ear, nose and throat specialty, has added the KOTLER NASAL ... KOTLER NASAL AIRWAY™ is a newly patented safety device secured by nasal surgeons ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016   ... sur le trimestre, soutenu par une croissance de ... Croissance de +16% des ventes aux hôpitaux et ... Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur de ... son chiffre d,affaires pour le premier trimestre clos ...
(Date:4/27/2016)... NEW DELHI , April 27, 2016 ... CSR initiative to save newborns ... ,s hospital for women & newborns in collaboration with Breast ... has launched the first Pasteurized Human Milk Bank, ,Amaara, in ... the best nutritional food source for infants and should be ...
(Date:4/27/2016)... April 27, 2016 Global  ... 2.14 billion by 2022, according to a new ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... the efficiency and accuracy delivered by the new ... for novel urinalysis instruments and consumables. For instance, ...
Breaking Medicine Technology: