Navigation Links
Canadian researchers discover the first-ever link between intelligence and curiosity

TORONTO, Sept. 15 /PRNewswire/ - Scientists from the Samuel Lunenfeld Research Institute of Mount Sinai Hospital in Toronto have discovered a molecular link between intelligence and curiosity, which may lead to the development of drugs to improve learning.

In a paper, published in Neuron, Dr. John Roder, Senior Investigator at the Lunenfeld, and Bechara Saab, Ph.D candidate at the Lunenfeld, studied the interaction of two proteins in a small region of the brain called the dentate gyrus (part of the hippocampus, which plays a role in long-term memory and spatial navigation).

For the study, the neuronal calcium sensor-1 (NCS-1), a protein which is known to affect the memory of worms and is linked to bipolar and schizophrenia in people, was increased by one-and-a-half fold specifically in the dentate gyrus of mouse models. This modest overexpression increased the ability of brain cells to change how they communicate with each other and gave the mice superior memory in complex tasks and a significant increase in exploratory behaviour (curiosity). Because the exploratory behaviour was only altered in safe environments, Dr. Roder and Saab believe they have discovered a region of the brain that generates curiosity and a model for how brain activity leads to curiosity.

The researchers also discovered that both curiosity and spatial memory were impaired when a benign drug blocked the NCS-1 protein from binding to the dopamine type-2 receptors (a major target of anti-psychotics) in the dentate gyrus.

"Now that we know that some of the molecules and brain regions that control learning and memory also control curiosity, we can go back to the lab and design drugs that may improve cognition in humans - that's the potential benefit for the future," explains Saab. "Immediately, however, we can put into use the knowledge that fostering curiosity should also foster intelligence and vice versa."

The study was funded by the Canadian Institutes for Health Research.

    About the Samuel Lunenfeld Research Institute:
    For information, please visit

SOURCE Mount Sinai Hospital
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Queens study to test Canadian guidelines for daily exercise
2. Elsevier and Canadian College of Health Service Executives announce new publishing partnership
3. NeuroVasx Receives Canadian Approval for cPAX Aneurysm Treatment System
4. Canadians Travel to Detroit Town Meeting to Talk About Their Health Care
5. The National Health Care Anti-Fraud Association Signs Memorandum of Understanding With Canadian and European Anti-Fraud Organizations
6. Narconon Trois-Rivieres Cites Hillbilly Heroin as Canadian Drug Addiction Crisis
7. Canadian Bio Med Attacks Worlds Leading Cause of Blindness
8. Live Broadcast of Drug Rehab Graduation at Canadian Narconon
9. Purolator USA Offers Canadian Customs Expertise for Medical Device Exports
10. Streamline Health Document Workflow Solution to be Integrated Into Electronic Medical Records System for Leading Canadian Healthcare Region
11. iUniverse Hosts Canadian Storytellers, Cystic Fibrosis Awareness Advocate for BookExpo America 2009 Book Signings
Post Your Comments:
(Date:12/1/2015)... ... 2015 , ... For many X-rays taken at hospitals, doctors’ ... by the radiologist. The marking utensils are so small, however, they are difficult ... way to alleviate this problem. , He developed the patent-pending MARK N SHOW ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... Health Center of Excellence (BHCOE) today announced that the organization has awarded Education ... San Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers ...
(Date:12/1/2015)... Burlington, MA (PRWEB) , ... December 01, 2015 , ... ... the release of Clarity, the latest addition to the devices for sale in the ... technologies, 755 nm Alexandrite and long-pulsed 1064 nm Nd:YAG lasers, into a single platform ...
(Date:12/1/2015)... ... , ... XTC Semifinals 2016 - CES, Las Vegas, Nevada - ... CES 2016, the world’s largest Consumer Electronic Show, where they will present to a ... of Pacific Investments Veronica Serra, and venture capitalist Tim Draper among many other top ...
(Date:12/1/2015)... , ... December 01, 2015 , ... Nurotron Biotechnology Co., ... its largest order to date. , The order will be from the China ... Venus Cochlear Implant System is an effective solution for children and adults suffering from ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Virginia , 1 de diciembre de ... en tecnología para cuchillas de precisión, develó ... programa de identidad de marca. El nuevo ... el diseño y la ingeniería de productos ... la diferencia". ...
(Date:12/1/2015)... 1, 2015 Breg, Inc ., a ... today that it has been awarded three contracts by ... by Novation will have access to improved pricing for ... and soft goods dedicated to advancing orthopedic care.  ... aging U.S. population, rising prevalence of chronic conditions and ...
(Date:12/1/2015)... India , December 1, 2015 ... a new market research report "Nucleic Acid Labeling Market ... (PCR, Nick Translation, Random Primer, In Vitro Transcription, Reverse ... 2020", published by MarketsandMarkets, The global market is expected ... 1,271.8 Million in 2015, growing at a CAGR of ...
Breaking Medicine Technology: