Navigation Links
Can refined categorization improve prediction of patient survival in RECIST 1.1?
Date:4/15/2014

In a recent analysis by the RECIST Working Group published in the European Journal of Cancer, EORTC researchers had explored whether a more refined categorization of tumor response or various aspects of progression could improve prediction of overall survival in the RECIST database. They found that modeling target lesion tumor growth did not improve the prediction of overall survival above and beyond that of the other components of progression. The RECIST Working Group includes the EORTC, the United States National Cancer Institute, and the National Cancer Institute of Canada Clinical Trials Group.

Dr. Saskia Litire, EORTC Biostatistician and lead author of this study says, "The World Health Organization criteria developed back in 1979, and more recently RECIST (Response Evaluation Criteria in Solid Tumors) in 2000 and then revised in 2009 have provided us with a unified set of tools for assessing tumor burden. These criteria allow standardized, comparable evaluation of tumor shrinkage in clinical trials, between patients, between trials, and across a wide range of tumor types. Analyses such as ours are indispensable in understanding the role of each component when evaluating progressive disease."

In the RECIST Working Group analysis focusing on patients with breast cancer, colorectal cancer and lung cancer, 36% of the patients had new lesions, 28% had non-target progressive disease, and 49% had experienced target lesion growth. The researchers found that no matter which type of tumor the patient had, next to initial response and measurable progression, the presence of new lesions (Hazard Ratio ranging from 1.5 - 2.3) and non-target progressive disease (Hazard Ratio ranging from 1.5 - 2.0) were independent factors linked with worse overall survival in a multivariate model. Furthermore, the presence of new lesions, the occurrence of non-target progressive disease and initial response carried at least as much explanatory value for overal
'/>"/>

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dr. Kabaker Achieves Excellent Results with New, Refined Techniques in Hairline Lowering
2. Clinical insight improves treatment with new lung cancer drug
3. Improved Stem Cell Line May Avoid Tumor Risk: Study
4. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
5. Exercise improves quality of life during breast cancer treatment
6. IU, Regenstrief automated system aims to improve child health
7. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
8. MU receives national award for using mind-body approach to improve health
9. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Naturopathic care can improve blood sugar, mood in diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... OH (PRWEB) April 27, 2015 Douglas ... to help his clients feel secure, but also helps secure ... to 7 p.m., Douglas will be manning a booth at ... Center, Lausche Building, 717 E. 17th Ave., Columbus, Ohio. ... worthy event that will feature hundreds of adoptable pets from ...
(Date:4/27/2015)... Ticket Down is a reputable source ... Valley Music Theatre and the Isleta Amphitheater. ... Mexico area can celebrate because their favorite performer will ... Buffett will be performing alongside legendary performers, Huey Lewis ... during the summer and fall months of 2015 are ...
(Date:4/27/2015)... 2015 The global coagulation analyzers ... CAGR in developed countries; however, it is expected ... as China, India and Brazil in the next ... is driven by factors such as increasing adoption ... of high-throughput hemostasis analyzers, developments in high-sensitivity point-of-care ...
(Date:4/27/2015)... 2015 Volpara Solutions today announced ... the Society of Breast Imaging’s SBI/ACR Breast Imaging ... Booth #214). VolparaDensity, the first breast density ... breast tomosynthesis datasets from multiple manufacturers, is already ... and worldwide. , The latest version ...
(Date:4/27/2015)... Puroast Coffee has signed on to sponsor the ... BattleFrog OCR is a series of rigorous courses designed by ... the training that Seals undergo, as well as provide a ... to sponsor the BattleFrog events this year,” says Puroast CEO ... well-suited to give people throughout the country the chance to ...
Breaking Medicine News(10 mins):Health News:Farmers Insurance Agent Douglas Fitzpatrick Ensures Pets Find Homes 2Health News:Cheap Jimmy Buffett Tickets at Alpine Valley Music Theatre in Elkhorn, WI and at Isleta Amphitheater in Albuquerque, NM Now on Sale at TicketDown.com 2Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 2Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 3Health News:Volpara Solutions Releases VolparaDensity 3.1 for Use with Tomosynthesis Systems from Multiple Manufacturers at SBI 2Health News:Volpara Solutions Releases VolparaDensity 3.1 for Use with Tomosynthesis Systems from Multiple Manufacturers at SBI 3Health News:Puroast Coffee on Tour with BattleFrog 2
... Reporter , MONDAY, April 18 (HealthDay News) -- New ... stay clear of AIDS longer if they start drug ... However, starting treatment earlier, compared to waiting, didn,t ... benefit in terms of preventing death" by prescribing the ...
... , MONDAY, April 18 (HealthDay News) -- Patients with ... die after surgery, even after non-emergency procedures, a new study ... be used to revive someone who is clinically unresponsive and ... 18 and in the August print issue of the journal ...
... New research finds that older diabetics with better control of ... as heart attacks, amputation and kidney disease. However, ... sugar levels face a slightly higher chance of dying than ... normal range. Researchers tracked more than 70,000 people with ...
... , MONDAY, April 18 (HealthDay News) -- Infection with ... many college students -- and little exposure to sunlight may ... a new study suggests. "MS is more common at ... researcher, Dr. George C. Ebers, of the University of Oxford ...
... ovarian cancer (HGSOC), the fifth-deadliest cancer among American women, ... fallopian tube malignancy masquerading as an ovarian one. While ... tubes has so far been only circumstantial, a new ... connection, a finding that could aid in the development ...
... Ill. Nearly 800 dental sleep medicine professionals from ... Meeting of the American Academy of Dental Sleep Medicine ... at the Hilton Minneapolis in Minneapolis, Minn. The meeting ... 25th Anniversary Meeting of the Associated Professional Sleep Societies. ...
Cached Medicine News:Health News:Starting HIV Drugs Earlier May Delay AIDS But Not Death 2Health News:Starting HIV Drugs Earlier May Delay AIDS But Not Death 3Health News:People With DNR Orders More Apt to Die After Any Surgery 2Health News:Low Glucose Levels May Raise Death Risk Among Older People 2Health News:Can Common Virus, Lack of Sunlight Boost MS Risk? 2Health News:New scientific model tracks form of ovarian cancer to origins in fallopian tube 2Health News:New scientific model tracks form of ovarian cancer to origins in fallopian tube 3
(Date:4/27/2015)... , April 27, 2015   AMC Health ... will showcase advances in monitored care that are transforming ... ATA 2015 Conference, May 2-5 at the ... AMC Health will share information about how their ... to help transform and personalize healthcare delivery at Booth ...
(Date:4/27/2015)... -- The North America ... $4,211.2 million by 2019, at a CAGR of 5.0% from ... the North America ophthalmology surgery device ... It also provides a glimpse of the segmentation of this ... tables and figures. http://www.micromarketmonitor.com/market/north-america-ophthalmology-surgery-devices-9102894245.html ...
(Date:4/27/2015)... 27, 2015 PAML announced today that ... with Axela, Inc. to develop multiplex assays focused ... one of the nation,s leading medical reference laboratories, ... protein analysis for clinical diagnostics. ... and assay development serves as the foundation for ...
Breaking Medicine Technology:AMC Health to Showcase Advances in Monitored Care at ATA 2015 2AMC Health to Showcase Advances in Monitored Care at ATA 2015 3AMC Health to Showcase Advances in Monitored Care at ATA 2015 4North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 3PAML and Axela Collaborate on Immune Status for Vaccine Preventable Diseases 2
... SAN DIEGO, Nov. 2, 2011 Amylin Pharmaceuticals, Inc. (Nasdaq: ... Suisse 2011 Healthcare Conference in Phoenix on Wednesday, November 9, ... M. Bradbury, president and chief executive officer, Amylin Pharmaceuticals, will ... webcast live through the "Investors" section of Amylin,s corporate website ...
... Inc. (NASDAQ: IPHS ), the leading North ... beverage, pharmaceutical, oral care and industrial end markets, today ... and completed the acquisition of Kelatron Corporation. ... manufacturer of bioactive mineral nutrients. For over 30 years, ...
Cached Medicine Technology:Innophos Holdings, Inc. Announces Acquisition of Kelatron Corporation 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: