Navigation Links
Can refined categorization improve prediction of patient survival in RECIST 1.1?
Date:4/15/2014

In a recent analysis by the RECIST Working Group published in the European Journal of Cancer, EORTC researchers had explored whether a more refined categorization of tumor response or various aspects of progression could improve prediction of overall survival in the RECIST database. They found that modeling target lesion tumor growth did not improve the prediction of overall survival above and beyond that of the other components of progression. The RECIST Working Group includes the EORTC, the United States National Cancer Institute, and the National Cancer Institute of Canada Clinical Trials Group.

Dr. Saskia Litire, EORTC Biostatistician and lead author of this study says, "The World Health Organization criteria developed back in 1979, and more recently RECIST (Response Evaluation Criteria in Solid Tumors) in 2000 and then revised in 2009 have provided us with a unified set of tools for assessing tumor burden. These criteria allow standardized, comparable evaluation of tumor shrinkage in clinical trials, between patients, between trials, and across a wide range of tumor types. Analyses such as ours are indispensable in understanding the role of each component when evaluating progressive disease."

In the RECIST Working Group analysis focusing on patients with breast cancer, colorectal cancer and lung cancer, 36% of the patients had new lesions, 28% had non-target progressive disease, and 49% had experienced target lesion growth. The researchers found that no matter which type of tumor the patient had, next to initial response and measurable progression, the presence of new lesions (Hazard Ratio ranging from 1.5 - 2.3) and non-target progressive disease (Hazard Ratio ranging from 1.5 - 2.0) were independent factors linked with worse overall survival in a multivariate model. Furthermore, the presence of new lesions, the occurrence of non-target progressive disease and initial response carried at least as much explanatory value for overall survival as progression based on measurable disease.


'/>"/>

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer
Source:Eurekalert

Related medicine news :

1. Dr. Kabaker Achieves Excellent Results with New, Refined Techniques in Hairline Lowering
2. Clinical insight improves treatment with new lung cancer drug
3. Improved Stem Cell Line May Avoid Tumor Risk: Study
4. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
5. Exercise improves quality of life during breast cancer treatment
6. IU, Regenstrief automated system aims to improve child health
7. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
8. MU receives national award for using mind-body approach to improve health
9. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Naturopathic care can improve blood sugar, mood in diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... patient payment industry today announced its strategic partnership with Connance, a healthcare ... , The two companies’ proven, proprietary technology combine to provide health systems, ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: