Navigation Links
Can recycling be used to treat cancer?
Date:7/7/2008

We already know that recycling benefits our planet; and now new research suggests that the cellular version might be useful for battling cancer. Scientists at Stanford University have identified a molecule that uses this unexpected pathway to selectively kill cancer cells. The research, published by Cell Press in the July 8th issue of the journal Cancer Cell, may drive treatment strategies for cancer in an entirely new direction.

Renal cell carcinoma (RCC), the most common form of kidney cancer, is nearly always caused by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene and often does not respond well to treatment.

"Since RCCs have a poor prognosis and are refractory to standard chemotherapies, there is a need to develop new therapies for kidney cancer," says senior author Dr. Amato J. Giaccia. Dr. Giaccia and colleagues used a sophisticated screening procedure to search for molecules that could selectively destroy VHL-deficient kidney cancer.

"Specifically identifying and targeting the cancer cells, while leaving normal cells intact should have great therapeutic impact. Most side effects people associate with chemotherapy, such as nausea and hair loss, are due to toxic effects of drugs on normal tissues. Exploiting a feature of cancer cells should spare the normal tissue and decrease these awful side effects," explains Dr. Giaccia.

The researchers discovered a compound, STF-62247, that was selectively toxic to RCCs deficient in VHL whereas cells with normal VHL were not affected. Treatment of RCC cells lacking functional VHL induced autophagy, a cellular recycling process that cells normally use to conserve resources during times of stress. "Increasing evidence implicates a role for autophagy in cancer, but it is not well understood how cellular and environmental cues drive autophagic cells down survival or death pathways," explains Dr. Giaccia.

The researchers demonstrated that STF-62247 enhanced autophagy in VHL-deficient cells while inhibition of the autophagy pathway significantly increased the survival of VHL-deficient cells treated with STF-62247. "We have found a small molecule that selectively induces cell death in VHL-deficient cells, such as those that are found in kidney cancer. This represents a paradigm shift for targeted therapy," concludes Dr. Giaccia.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. ReCellular and American Red Cross Announce Cell-Phone Recycling Campaign
2. CoffeeCakes.com Has Recycling In the Bag
3. Cell recycling protects tumor cells from anti-cancer therapy
4. ReCellular Named Exclusive Cell Phone Recycling Partner for Consumer Cellular
5. Aggressive treatment of childhood eczema could help prevent asthma, says new study
6. Stem cells from umbilical cord used in the treatment of hepatic diseases
7. Breakthrough Technology That Will Revolutionize the Treatment of Tooth Decay
8. Two-Drug Treatment Didnt Improve Cardiac Arrest Survival Rates
9. Natural Remedies to Treat Animals Complex Emotions
10. New Ear Tube Device Helps Treat Infections Faster
11. Glaucoma Treatment Can Prevent Blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... ... provide first-quality education and high-level training standards to an international multidisciplinary group of ... disorder problems. As a way to further its mission at the grassroots level, ...
(Date:1/16/2017)... CA (PRWEB) , ... January 16, 2017 , ... San ... of iTero Element, the latest in 3-D scanning device which is capable of taking ... the latest advances in dentistry, such as CAD CAM restorations , in terms ...
(Date:1/16/2017)... ... ... NexTec Group has been selected as a member of the Bob Scott’s VAR ... field of midmarket financial software. , Members of the VAR Stars were selected based ... on revenue and those firms chosen represent a wide range of size and many ...
(Date:1/15/2017)... ... January 15, 2017 , ... Going above and beyond ... strives to better communities around the world by offering the Gensuite team and ... opportunity for team members to become involved in a cause that is bigger ...
(Date:1/15/2017)... ... 2017 , ... Accreditation Commission for Health Care (ACHC) is ... services. Albertsons Companies is the largest national food and drug chain with ... Accreditation by ACHC reflects Albertsons Companies’ dedication and commitment to meeting national standards ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... CRUZ, Calif. , Jan. 16, 2017  Dovetail ... Dovetail™ Hi-C sequencing and assembly service, which yields chromosome-scale ... be presented in a Dovetail-hosted workshop on Jan. 17 ... in San Diego . ... services with the launch of our Dovetail Hi-C offering," ...
(Date:1/16/2017)... 2017  Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX) is pleased ... , CFA to its Board of Directors. He is ... Asset Management LLC . He is also the Chief ... investment advisory firm with over $1.5 billion under management. ... in security analysis and portfolio management. He began his ...
(Date:1/15/2017)... DUBLIN , January 16, 2017 ... produits innovants à base de collagène pour la régénération de ... au poste de directeur général avec effet immédiat. ... Bill est ... qui a occupé plusieurs postes de gestion générale et de ...
Breaking Medicine Technology: