Navigation Links
Can recycling be used to treat cancer?
Date:7/7/2008

We already know that recycling benefits our planet; and now new research suggests that the cellular version might be useful for battling cancer. Scientists at Stanford University have identified a molecule that uses this unexpected pathway to selectively kill cancer cells. The research, published by Cell Press in the July 8th issue of the journal Cancer Cell, may drive treatment strategies for cancer in an entirely new direction.

Renal cell carcinoma (RCC), the most common form of kidney cancer, is nearly always caused by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene and often does not respond well to treatment.

"Since RCCs have a poor prognosis and are refractory to standard chemotherapies, there is a need to develop new therapies for kidney cancer," says senior author Dr. Amato J. Giaccia. Dr. Giaccia and colleagues used a sophisticated screening procedure to search for molecules that could selectively destroy VHL-deficient kidney cancer.

"Specifically identifying and targeting the cancer cells, while leaving normal cells intact should have great therapeutic impact. Most side effects people associate with chemotherapy, such as nausea and hair loss, are due to toxic effects of drugs on normal tissues. Exploiting a feature of cancer cells should spare the normal tissue and decrease these awful side effects," explains Dr. Giaccia.

The researchers discovered a compound, STF-62247, that was selectively toxic to RCCs deficient in VHL whereas cells with normal VHL were not affected. Treatment of RCC cells lacking functional VHL induced autophagy, a cellular recycling process that cells normally use to conserve resources during times of stress. "Increasing evidence implicates a role for autophagy in cancer, but it is not well understood how cellular and environmental cues drive autophagic cells down survival or death pathways," explains Dr. Giaccia.

The researchers demonstrated that STF-62247 enhan
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. ReCellular and American Red Cross Announce Cell-Phone Recycling Campaign
2. CoffeeCakes.com Has Recycling In the Bag
3. Cell recycling protects tumor cells from anti-cancer therapy
4. ReCellular Named Exclusive Cell Phone Recycling Partner for Consumer Cellular
5. Aggressive treatment of childhood eczema could help prevent asthma, says new study
6. Stem cells from umbilical cord used in the treatment of hepatic diseases
7. Breakthrough Technology That Will Revolutionize the Treatment of Tooth Decay
8. Two-Drug Treatment Didnt Improve Cardiac Arrest Survival Rates
9. Natural Remedies to Treat Animals Complex Emotions
10. New Ear Tube Device Helps Treat Infections Faster
11. Glaucoma Treatment Can Prevent Blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Santa Rosa, California (PRWEB) September 21, 2014 ... aged 40–44 experienced the highest birth rate since 1966 (10.5 ... for women in their early 40s has risen steadily by ... 45–49 (which includes births to women aged 50 and over) ... data reveals that there were more than nine times as ...
(Date:9/20/2014)... (PRWEB) September 21, 2014 Recently, iFitDress.com, a ... selection of beautiful party dresses . In addition, the ... the main aim of the promotion is to benefit all ... outfits in its online store now. , Along with ... of graceful items. It has recently released its new sexy ...
(Date:9/20/2014)... Diabetes Protocol , a breakthrough ... helping thousands of people learn how to naturally manage ... or prescriptions has caught the attention of Shane Michaels, ... tens of millions of people in the U.S. today ... diabetes, and unfortunately, big pharma makes a killing just ...
(Date:9/20/2014)... 6 Minutes to Skinny , a fat loss ... is showing men and women of all ages how they ... using simple 6-minute exercises and easy-to-follow lifestyle tips daily, has ... , “When it comes to losing body fat, unfortunately ... all people,” reports Michaels. “Metabolism plays a big role in ...
(Date:9/20/2014)... 20, 2014 The Villa Group announced ... Palmar Cabo San Lucas, Villa La Estancia and Villa ... Odile, with plans to welcome guests back to the ... Sept. 19, all members and guests of the Villa ... a coordinated effort with government authorities. , Hurricane ...
Breaking Medicine News(10 mins):Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2Health News:Villa Group Resorts in Cabo Largely Unharmed, Plan to Re-open Early October 2
... artificial teeth that they say could replace the natural ... in humans. ,In the technique, researchers developed ... the mouths of adult mice and said this could ... edition of Australia's The Daily Telegraph. ,Writing ...
... given birth should not worry about getting their bodies back ... ,"A woman's body has enough to do after a ... adjustment as examples. ,New mothers also have to ... to nurse, added Pfarrer of the insurer DAK in Hamburg. ...
... among Victorian hospital staff could be putting the health ... experts. ,A study published in the ... of Victorian health workers in public hospitals were vaccinated ... through the national vaccination program. ,'Influenza ...
... has been closed to patients and visitors after an outbreak ... staff members of the hospital and many patients have been ... responsible for causing disorders affecting the intestine resulting in severe ... may last for two to three days but are severely ...
... have been prescribed for the officials of Thailand government. The ... be health conscious to inspire the rest of the nation. ... obesity in Thailand is on the rise at an alarming ... of every twenty one Thai is said to suffer from ...
... Sure you think about diet and exercise as key to ... in? // ,According to a new study from ... disease and associated fatalities are higher for people who live ... areas. ,'This is one of the largest studies ...
Cached Medicine News:Health News:Living in Poor Neighborhoods Raises Risks for Heart Disease and Stroke 2
(Date:9/19/2014)... DALLAS , Sept. 19, 2014 /PRNewswire-iReach/ ... Chinese Oxybutynin Hydrochloride Industry, 2009-2019 is a ... and Chinese Oxybutynin Hydrochloride industry. The report ... Hydrochloride including its classification, application and manufacturing ... China,s top manufacturers of Oxybutynin Hydrochloride listing ...
(Date:9/19/2014)...  The board of directors of AbbVie Inc. (NYSE: ... of $0.42 per share.  The cash ... record at the close of business on Oct. 15, ... research-based biopharmaceutical company formed in 2013 following separation from ... dedicated people and unique approach to innovation to develop ...
(Date:9/19/2014)... -- Merck (NYSE: MRK ), known as MSD outside ... , is teaming with celebrity chef and cookbook author Leticia ... an educational program encouraging Hispanics with type 2 diabetes to achieve ... to help reduce the risk of serious health problems. Hispanics in ... risk for developing type 2 diabetes than non-Hispanic white adults, and ...
Breaking Medicine Technology:Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5
... (vRad), a technology-enabled national radiology practice, announced ... Radiology Associates (MRA) have joined its Pennsylvania-based ... (DII). These former MRA radiologists will continue ... and join the more than 60 DII ...
... 2011  The Austen BioInnovation Institute in Akron (ABIA) ... today a strategic partnership to share expertise while ... The partnership combines the polymer ... of ABIA with Lubrizol, a key medical polymer ...
Cached Medicine Technology:vRad Radiology Alliance Continues to Transform Radiology With Most Recent Practice Partnership 2Austen BioInnovation Institute and Lubrizol Announce New Strategic Innovation Partnership 2Austen BioInnovation Institute and Lubrizol Announce New Strategic Innovation Partnership 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: