Navigation Links
Can recycling be used to treat cancer?
Date:7/7/2008

We already know that recycling benefits our planet; and now new research suggests that the cellular version might be useful for battling cancer. Scientists at Stanford University have identified a molecule that uses this unexpected pathway to selectively kill cancer cells. The research, published by Cell Press in the July 8th issue of the journal Cancer Cell, may drive treatment strategies for cancer in an entirely new direction.

Renal cell carcinoma (RCC), the most common form of kidney cancer, is nearly always caused by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene and often does not respond well to treatment.

"Since RCCs have a poor prognosis and are refractory to standard chemotherapies, there is a need to develop new therapies for kidney cancer," says senior author Dr. Amato J. Giaccia. Dr. Giaccia and colleagues used a sophisticated screening procedure to search for molecules that could selectively destroy VHL-deficient kidney cancer.

"Specifically identifying and targeting the cancer cells, while leaving normal cells intact should have great therapeutic impact. Most side effects people associate with chemotherapy, such as nausea and hair loss, are due to toxic effects of drugs on normal tissues. Exploiting a feature of cancer cells should spare the normal tissue and decrease these awful side effects," explains Dr. Giaccia.

The researchers discovered a compound, STF-62247, that was selectively toxic to RCCs deficient in VHL whereas cells with normal VHL were not affected. Treatment of RCC cells lacking functional VHL induced autophagy, a cellular recycling process that cells normally use to conserve resources during times of stress. "Increasing evidence implicates a role for autophagy in cancer, but it is not well understood how cellular and environmental cues drive autophagic cells down survival or death pathways," explains Dr. Giaccia.

The researchers demonstrated that STF-62247 enhanced autophagy in VHL-deficient cells while inhibition of the autophagy pathway significantly increased the survival of VHL-deficient cells treated with STF-62247. "We have found a small molecule that selectively induces cell death in VHL-deficient cells, such as those that are found in kidney cancer. This represents a paradigm shift for targeted therapy," concludes Dr. Giaccia.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. ReCellular and American Red Cross Announce Cell-Phone Recycling Campaign
2. CoffeeCakes.com Has Recycling In the Bag
3. Cell recycling protects tumor cells from anti-cancer therapy
4. ReCellular Named Exclusive Cell Phone Recycling Partner for Consumer Cellular
5. Aggressive treatment of childhood eczema could help prevent asthma, says new study
6. Stem cells from umbilical cord used in the treatment of hepatic diseases
7. Breakthrough Technology That Will Revolutionize the Treatment of Tooth Decay
8. Two-Drug Treatment Didnt Improve Cardiac Arrest Survival Rates
9. Natural Remedies to Treat Animals Complex Emotions
10. New Ear Tube Device Helps Treat Infections Faster
11. Glaucoma Treatment Can Prevent Blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. ... of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death ... podcasted thereafter . Dr. Bernie Siegel, author of a plethora of essential ...
(Date:4/29/2016)... Southlake, Texas (PRWEB) , ... April 29, 2016 , ... ... and neck pain, is proud to announce one of their physicians has been invited ... Osteopathic Family Physicians (Texas ACOFP) Family Practice Review conference on April 30, 2016. ...
(Date:4/29/2016)... ... ... Melanoma is the deadliest type of skin cancer. Although only about 1 percent of skin ... More than 10,000 people are expected to die of melanoma this year. The risk increases ... of the most commonly diagnosed cancers in young women. A recent breakthrough in genetic studies ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, ... round of funding led by Eastside Partners, with participation from existing investor Martin ... customer base and accelerate its technology and product roadmap. , “Jvion ...
(Date:4/29/2016)... ... ... Nike Softball Camp at the College of Brockport in New York is ... 10-18. All facets of the game will be covered; hitting, fielding, base-running, and team ... the finest softball facilities in the region. The outstanding professional college staff complement and ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , le 27 Avril 2016 ... a progressé de +5% sur le trimestre, soutenu ... de consommables  Croissance de +16% des ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; ... confocale laser, annonce aujourd,hui son chiffre d,affaires pour ...
(Date:4/27/2016)... April 27, 2016 Elekta today ... platform will be the focal point of seven scientific ... European Society for Radiotherapy & Oncology, taking place April ... a state-of-the-art radiotherapy system and a high-field MRI scanner ... see the patient,s anatomy in real time. The MR-linac ...
(Date:4/27/2016)... , April 27, 2016   Zillion ... digital health technology platform, which specializes in live ... into scalable digital products, Zillion enables companies to ... empower consumers to take control of their health. ... video conferencing – including one-to-one, group and webcast ...
Breaking Medicine Technology: