Navigation Links
Can rectal vitamin E induce remission in patients with mild to moderate ulcerative colitis?
Date:10/31/2008

It is believed that the generation of an exaggerated intestinal immune response to otherwise innocuous stimuli along with generation of oxygen free radicals plays a key role in the pathophysiology of UC. However, no disease-specific treatment for UC has yet emerged. Vitamin E is a major lipophilic antioxidant in cellular membranes with excellent antioxidant activities which protects membrane lipids from peroxidation by scavenging not only chain carrying peroxyl radicals but also singlet oxygen and superoxide anion radicals. This is especially interesting in case of UC, considering the pivotal role of oxygen free radicals in the genesis of mucosal damage. Given the recent evidence suggesting anti-inflammatory properties for Vitamin E, one may ask whether d-alpha tocopherol, as the dominant vitamin E isomer in plasma with the highest biopotency, can be expected to reduce the development of tissue injury in UC.

A research article to be published on October 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Mirbagheri from Department of Internal Medicine of Amir Alam hospital in Tehran-Iran, report for the first time the preliminary results of an on-going open-label case-series study on clinical and endoscopic changes of disease severity in patients with active UC who received daily rectal doses of d-alpha tocopherol for at least 12 wk.

All 15 participating patients responded dramatically to therapy after 12 weeks, with 9 of them going to clinical remission. The average score of Mayo disease activity index (DAI) started to decrease after second week and remained significantly lower for the remainder of the study. Besides, there was no case of worsening disease activity or report of serious adverse event during the course of study. The observed effect are probably due to antioxidant and anti-inflammatory effects of vitamin E which potently takes effect by local route of administration. At
'/>"/>

Contact: Lin-Lin Xiao
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
2. The fight against colorectal cancer
3. Simple, personalized interventions improve colorectal cancer screening rates
4. Studies lend insights into colorectal cancer screening
5. Virtual colonoscopy -- a new technology for colorectal cancer screening?
6. Frequently Asked Questions When Considering a Colorectal Cancer Screening Test, From the American College of Gastroenterology
7. 18F-DG PET/CT can highly increase the detection of colorectal cancer
8. Colorectal cancer screening remains essential for elderly Americans
9. Racial and ethnic differences in colorectal cancer emphasize importance of screening
10. ASGE Applauds News of Drop in Colorectal Cancer Deaths
11. Society of Gynecologic Oncologists Provides Guidelines for Offering Genetic Risk Assessment to Women With a Personal or Family History of Breast, Ovarian, Uterine or Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... (PRWEB) December 20, 2014 Recently, AngelWeddingDress.com ... Christmas Discount ”) for the coming Christmas. In the ... to 80% off. , “We have something special for ... for the holiday season. Moreover, our new collections of ... models are offered now at greatly discounted prices. Visit ...
(Date:12/20/2014)... Xarelto bleeding lawsuits filed by men ... and other serious side effects will be consolidated in ... coordinated pretrial proceedings, Wright & Schulte LLC reports. The ... order Friday to transfer 21 Xarelto lawsuits and over ... to the Louisiana district court for coordination by Judge ...
(Date:12/20/2014)... 20, 2014 Parker & Sons, Inc. ... years of experience in contractor services announces reaching a ... for the homeowners of Arizona. Parker and Sons is ... contractor technicians that make customer service the number one ... Arizona and started with one service vehicle and has ...
(Date:12/19/2014)... 2014 Today, Balfleet.com , a ... announces its formal dress promotion. All the old and ... 60% off. , Balfleet.com is well-known for its high ... prom dresses, cocktail dresses and more. Its formal dresses ... guarantee, and they can create an elegant look when ...
(Date:12/19/2014)... Sweetdressy.com , a leading wedding ... newest selection of cheap prom dresses for ladies worldwide. ... the world and clients can buy these dresses at ... dresses feature cool cuts and delicate craftsmanship, and most ... middle-end market. Discount shipping costs are available for all ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 3Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2
... people become less efficient at separating important from less ... Knowing this, clinicians may be able to train people ... information better, according to a report in the May ... Psychological Association. , Remembering what,s most important is ...
... PARK, Calif., May 4 Acclarent, Inc., the pioneer ... the treatment of chronic sinusitis, announced today that the ... 7,500,971, entitled "Devices, Systems and Methods for Treating Disorders ... This patent and Acclarent,s earlier 7,462,175 patent are ...
... Commonsense Steps to Prevent Spreading FluNORRISTOWN, Pa., May 3 ... Pennsylvania,s first laboratory-confirmed case of 2009 A/H1N1 in a ... a confirmed case, it is even more important for ... that can help prevent the spread of the flu," ...
... 2009) Identifying one of the processes that plays a ... one day lead to better vaccines and possibly more effective ... Texas Children,s Hospital in a report that appears in the ... work, Dr. Daniel Lacorazza, assistant professor of pathology at BCM, ...
... Journalistic Achievement Award Winners , ... New York, NY ... ABC News 20/20 are among winners receiving top honors in the ... Plastic Surgery (ASAPS). Selected from over 125 entries, this year,s ...
... of liposuction will be discussed by leading experts at the Annual Meeting ... the Mandalay Bay Hotel & Convention Center May 2-7, 2009. , ... ... will be discussed by leading experts at the Annual Meeting of the ...
Cached Medicine News:Health News:Memory grows less efficient very early in Alzheimer's disease 2Health News:Acclarent, Inc. Granted Key Patent Covering Balloon Sinuplasty(TM) Technologies 2Health News:Governor Rendell Announces Pennsylvania's First Confirmed Case of 2009 A/H1N1 Flu 2Health News:Governor Rendell Announces Pennsylvania's First Confirmed Case of 2009 A/H1N1 Flu 3Health News:Process controlling T cell growth and production identified 2Health News:Aesthetic Society Awards Journalists' Commitment To Patient Education 2Health News:Aesthetic Society Awards Journalists' Commitment To Patient Education 3Health News:Liposuction Turns 20 2Health News:Liposuction Turns 20 3Health News:Liposuction Turns 20 4
(Date:12/19/2014)... , Dec. 18, 2014 Research and ... the addition of the "Micro Market Monitor: ... to their offering. ... treatment is progressing steadily, which has resulted in ... devices market. The main purpose of these dermatology ...
(Date:12/19/2014)... 2014  Decision Resources Group finds that the laparoscopic ... will increase to a value of over $4.3 ... expansion in the large direct energy device market. In ... adopted due to the advantages they offer and as ... from Decision Resources Group,s coverage of the U.S. laparoscopic ...
(Date:12/19/2014)... 2014  RESMED INC. (NYSE: RMD ) today ... year 2015 results on Thursday, January 22, 2015, after the ... ResMed,s results will be issued after 1:00 p.m. US Pacific ... operating results and future outlook. The earnings call ... and the live webcast of the call can be accessed ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3ResMed To Announce Second Quarter 2015 Results 2
... MOUNT PROSPECT, Ill., March 22, 2011 The National Association ... the prescription monitoring programs (PMPs) of North Dakota , ... agreements to participate in the PMP Interconnect ™ system, ... United States to be linked, providing a more effective means ...
... 22, 2011 The U.S. Food and Drug Administration ... Ann Arbor, Mich., and two of its officers, Mark ... Lincoln, vice president of Quality Assurance and Operations, have ... (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) The ...
Cached Medicine Technology:Three States Sign on to Participate in NABP's Interconnected Prescription Monitoring System 2Three States Sign on to Participate in NABP's Interconnected Prescription Monitoring System 3FDA: Michigan Heart-Lung Bypass Machine Manufacturer Enters Into Consent Decree 2FDA: Michigan Heart-Lung Bypass Machine Manufacturer Enters Into Consent Decree 3
Agglutinating sera for serological identification of E. coli by slide and/or tube agglutination tests. Agglutinating sera are packaged 2 mL / vial....
... innovative E.coli 0157 latex ... definitive identification of E.coli ... of a proprietary antibody ... of cross-reactions with Escherichia ...
Inquire...
The Onar®Lp test system is an in vitro test for the qualitative diagnosis of legionella in clinical samples....
Medicine Products: