Navigation Links
Can rectal vitamin E induce remission in patients with mild to moderate ulcerative colitis?
Date:10/31/2008

It is believed that the generation of an exaggerated intestinal immune response to otherwise innocuous stimuli along with generation of oxygen free radicals plays a key role in the pathophysiology of UC. However, no disease-specific treatment for UC has yet emerged. Vitamin E is a major lipophilic antioxidant in cellular membranes with excellent antioxidant activities which protects membrane lipids from peroxidation by scavenging not only chain carrying peroxyl radicals but also singlet oxygen and superoxide anion radicals. This is especially interesting in case of UC, considering the pivotal role of oxygen free radicals in the genesis of mucosal damage. Given the recent evidence suggesting anti-inflammatory properties for Vitamin E, one may ask whether d-alpha tocopherol, as the dominant vitamin E isomer in plasma with the highest biopotency, can be expected to reduce the development of tissue injury in UC.

A research article to be published on October 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Mirbagheri from Department of Internal Medicine of Amir Alam hospital in Tehran-Iran, report for the first time the preliminary results of an on-going open-label case-series study on clinical and endoscopic changes of disease severity in patients with active UC who received daily rectal doses of d-alpha tocopherol for at least 12 wk.

All 15 participating patients responded dramatically to therapy after 12 weeks, with 9 of them going to clinical remission. The average score of Mayo disease activity index (DAI) started to decrease after second week and remained significantly lower for the remainder of the study. Besides, there was no case of worsening disease activity or report of serious adverse event during the course of study. The observed effect are probably due to antioxidant and anti-inflammatory effects of vitamin E which potently takes effect by local route of administration. At
'/>"/>

Contact: Lin-Lin Xiao
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
2. The fight against colorectal cancer
3. Simple, personalized interventions improve colorectal cancer screening rates
4. Studies lend insights into colorectal cancer screening
5. Virtual colonoscopy -- a new technology for colorectal cancer screening?
6. Frequently Asked Questions When Considering a Colorectal Cancer Screening Test, From the American College of Gastroenterology
7. 18F-DG PET/CT can highly increase the detection of colorectal cancer
8. Colorectal cancer screening remains essential for elderly Americans
9. Racial and ethnic differences in colorectal cancer emphasize importance of screening
10. ASGE Applauds News of Drop in Colorectal Cancer Deaths
11. Society of Gynecologic Oncologists Provides Guidelines for Offering Genetic Risk Assessment to Women With a Personal or Family History of Breast, Ovarian, Uterine or Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... (PRWEB) March 03, 2015 ... is estimated to grow from $1,224.6 million ... 6.71% between 2014 and 2019. , Browse ... delivery network market for an analysis of ... of various tables and figures., http://www.micromarketmonitor.com/market/north-america-application-delivery-network-adn-7381582251.html ...
(Date:3/3/2015)... Ann Arbor, MI (PRWEB) March 03, 2015 ... on NPR News Morning Edition, science correspondent Shankar Vedantam ... the University of Pennsylvania about the drastic decrease in hand-hygiene ... shift. He suggested that the problem could be solved in ... to perform hand hygiene when they enter and exit a ...
(Date:3/3/2015)... 03, 2015 Birth Boot Camp ... they now have over 130 certified instructors in more ... Germany. In addition, the company recently launched a new ... childbirth educator certification program . Birth Boot Camp is ... birth partner. The practical information can be used by ...
(Date:3/3/2015)... Vancouver, BC (PRWEB) March 03, 2015 ... iData Research ( http://www.idataresearch.com ), market saturation has ... of care in the United States. Unit sales ... continue to increase as facilities replace older systems, ... neurosurgery navigation system market is very much a ...
(Date:3/3/2015)... Celestix Networks, the leading provider of ... global availability of Celestix Cloud Edge Security Appliance ... deployed platform for DirectAccess and remote access roles ... release enables organizations to manage the Windows® Server ... HTML 5 web interface called Comet 2.0. ...
Breaking Medicine News(10 mins):Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 2Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 3Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 2Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 3Health News:Expectant Couples Worldwide Can Now Receive Training and Education in Natural Childbirth and Breastfeeding from Birth Boot Camp 2Health News:Neurosurgery Navigation System Market Reaches Saturation in the United States 2Health News:Neurosurgery Navigation System Market Reaches Saturation in the United States 3Health News:Introducing Celestix Cloud Edge Security 2.0 for Increased Security in DirectAccess Client Management 2Health News:Introducing Celestix Cloud Edge Security 2.0 for Increased Security in DirectAccess Client Management 3
... our stomach may reduce the protective effects of antioxidants ... Glasgow found that in the presence of lipid the ... component of vitamin C), to protect against the generation ... than when no lipids are present. “Our results illustrate ...
... the blues? There’s nothing like getting down and dirty say ... ,The study led by Dr. Chris Lowry ... Mycobacterium vaccae, can actually replicate the effects of anti- depressant ... of lung cancer patients who were treated with the ...
... at those simple, inexpensive, often boisterous bistros that made Paris ... ,The reason is that a number of young chefs, ... to exercise their talents in the casual atmosphere of a ... of vying for a Michelin star. ,As a ...
... California, San Diego (UCSD) School of Medicine have discovered ... with increased clotting of the blood, which has previously ... published in the March issue of CHEST, the official ... ,'In previous work, we have found that sleep ...
... be hailed as a leprosy-free zone by health administrators worldwide. ... more are suffering// from the terrifying disease. ,But ... point out. And the stigma the disease carries with it ... an ancient, much feared disease. But although it is infectious ...
... showing actors blowing glorious rings of smoke or village ... reach for those below 18 years//. ,An ... against tobacco consumption has suggested that films showing smoking ... ,Public Health Foundation of India (PHFI), an autonomous ...
Cached Medicine News:Health News:Be Happy- Get On Your Knees And Play In The Mud 2Health News:'Bistronomy' is Conquering Dining in Paris 2Health News:'Bistronomy' is Conquering Dining in Paris 3Health News:Indian Films With Smoking Scenes may Get 'A' Certificate 2
(Date:3/3/2015)... HOUSTON , March 3, 2015  Cyberonics, Inc. ... medical devices for the treatment and management of epilepsy, ... Healthcare Conference on Wednesday, March 11, 2015, in ... , Cyberonics, President and Chief Executive Officer, will speak ... conducted in a fireside chat format, and no formal ...
(Date:3/3/2015)... BETHESDA, Md. , March 3, 2015 /PRNewswire/-- ViaCyte, Inc., ... cell-derived islet replacement therapy for the treatment of diabetes ... Eugene Brandon , Director of Strategic Relations and ... summit showcases the latest in type 1 diabetes management ... are as follows: , , , Title:   ...
(Date:3/3/2015)... , March 3, 2015  Cannabis Science, Inc. (OTCQB: ... cannabis-based medicine, today announced two important developments: It launched ... global product launches, and CEO Raymond C. Dabney ... HR Examiner. In the article, Dabney answers ... leading a company in an industry that is too ...
Breaking Medicine Technology:ViaCyte to Present at JDRF TypeOneNation Research Summit 2CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 2CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 3CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 4CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 5
... announced that Xeomin ® (incobotulinumtoxinA), a new botulinum toxin ... (CD)or blepharospasm, is now commercially available in the U.S. XEOMIN ... on July 30, 2010. XEOMIN is a botulinum ... is FDA-approved for the treatment of adults with cervical dystonia, ...
... 5 Lixte Biotechnology Holdings (OTC: ... Experimental Therapeutics (NExT) Program Senior Advisory Committee (SAC), ... Cancer Institute (NCI), National Institutes of Health (NIH), ... collaboration with Lixte Biotechnology Holdings, Inc. for clinical ...
Cached Medicine Technology:Xeomin® (incobotulinumtoxinA) - a Botulinum Toxin Free From Accessory Proteins - Now Available in the U.S. 2Xeomin® (incobotulinumtoxinA) - a Botulinum Toxin Free From Accessory Proteins - Now Available in the U.S. 3Xeomin® (incobotulinumtoxinA) - a Botulinum Toxin Free From Accessory Proteins - Now Available in the U.S. 4Xeomin® (incobotulinumtoxinA) - a Botulinum Toxin Free From Accessory Proteins - Now Available in the U.S. 5Xeomin® (incobotulinumtoxinA) - a Botulinum Toxin Free From Accessory Proteins - Now Available in the U.S. 6Lixte Biotechnology Holdings, Inc. Announces the Approval of a Collaboration with the National Cancer Institute for Clinical Evaluation of its Lead Anti-Cancer Compound, LB-100. 2Lixte Biotechnology Holdings, Inc. Announces the Approval of a Collaboration with the National Cancer Institute for Clinical Evaluation of its Lead Anti-Cancer Compound, LB-100. 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: