Navigation Links
Can pathological techniques help identify primary colorectal signet ring cell carcinoma?
Date:5/20/2008

Primary colorectal signet ring cell carcinoma is a rare but distinctive malignancy of the large bowel. More than 96% of signet ring cell carcinomas arise in the stomach, with the rest arising from other primary organs. Therefore, a secondary infiltration or metastasis to the colon and rectum must be excluded before a definite diagnosis of primary colorectal signet ring cell carcinoma can be established.

This research, performed by a team led by Professor Hsien Lin Sim, is described in an article to be published on April 7, 2008 in the World Journal of Gastroenterology.

The patient presented with a clinical picture of primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries. Immunohistochemical studies were attempted to differentiate between a gastric and colonic primary. Both specimens were positive for cytokeratins 7 (CK 7) and cytokeratins 20 (CK 20).

Immunostaining profiles for CK 7 and CK 20 have been used to characterize and differentiate signet ring cell carcinoma of breast, stomach and colon. It has been suggested a colon primary is supported if the neoplastic cells have CK 7(-)/CK 20(+) staining pattern, and a gastric primary is supported if they have a CK 7(+)/CK 20(-) staining pattern.

To date, a primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries had not been described. This case certainly illustrated the aggressive nature of signet ring cell carcinoma. Dr Sim and her colleagues from the Department of Surgery, Alexandra Hospital, proposed that immunohistochemistry may not be 100% accurate in predicting the primary source of signet ring cell carcinoma.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. U of M study: Health food supplement may curb addiction of pathological gamblers
2. Does Pathological Shyness Make for School Shooters?
3. New genetic techniques to combat lung cancer
4. Researchers sharpen search for new marine medicines with novel techniques
5. New techniques improve imaging quality, not diagnosis of Barretts esophagus
6. Biopsy techniques have made PSA test less predictive
7. New Technology and Improved Techniques Arm Dermatologists With Tools to Minimize Facial Scars From Skin Cancer Surgery
8. Improved diagnosis of cutaneous leishmaniasis thanks to new techniques
9. MRI techniques evolving towards better assessment of liver fibrosis
10. Exploring the Use of Techniques From Neuroscience in Todays Marketing
11. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... While it’s often important to take certain medications during the night, ... has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX ... eliminates the need to turn on a light when taking medication during the night, ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a ... utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the ... a CBD form that can be easily incorporated into liquid products, while reducing costs ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
(Date:10/2/2017)... -- AllianceRx Walgreens Prime, the combined central specialty pharmacy and ... manager Prime Therapeutics LLC (Prime), today officially began the ... of new signage at its headquarters in ... few other company-owned facilities across the country. This also ... whom will begin to see the AllianceRx Walgreens Prime ...
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
Breaking Medicine Technology: