Navigation Links
Can pathological techniques help identify primary colorectal signet ring cell carcinoma?
Date:5/20/2008

Primary colorectal signet ring cell carcinoma is a rare but distinctive malignancy of the large bowel. More than 96% of signet ring cell carcinomas arise in the stomach, with the rest arising from other primary organs. Therefore, a secondary infiltration or metastasis to the colon and rectum must be excluded before a definite diagnosis of primary colorectal signet ring cell carcinoma can be established.

This research, performed by a team led by Professor Hsien Lin Sim, is described in an article to be published on April 7, 2008 in the World Journal of Gastroenterology.

The patient presented with a clinical picture of primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries. Immunohistochemical studies were attempted to differentiate between a gastric and colonic primary. Both specimens were positive for cytokeratins 7 (CK 7) and cytokeratins 20 (CK 20).

Immunostaining profiles for CK 7 and CK 20 have been used to characterize and differentiate signet ring cell carcinoma of breast, stomach and colon. It has been suggested a colon primary is supported if the neoplastic cells have CK 7(-)/CK 20(+) staining pattern, and a gastric primary is supported if they have a CK 7(+)/CK 20(-) staining pattern.

To date, a primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries had not been described. This case certainly illustrated the aggressive nature of signet ring cell carcinoma. Dr Sim and her colleagues from the Department of Surgery, Alexandra Hospital, proposed that immunohistochemistry may not be 100% accurate in predicting the primary source of signet ring cell carcinoma.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. U of M study: Health food supplement may curb addiction of pathological gamblers
2. Does Pathological Shyness Make for School Shooters?
3. New genetic techniques to combat lung cancer
4. Researchers sharpen search for new marine medicines with novel techniques
5. New techniques improve imaging quality, not diagnosis of Barretts esophagus
6. Biopsy techniques have made PSA test less predictive
7. New Technology and Improved Techniques Arm Dermatologists With Tools to Minimize Facial Scars From Skin Cancer Surgery
8. Improved diagnosis of cutaneous leishmaniasis thanks to new techniques
9. MRI techniques evolving towards better assessment of liver fibrosis
10. Exploring the Use of Techniques From Neuroscience in Todays Marketing
11. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Pets bring laughter, joy and ... appreciation, pet owners celebrate National Pet Week, which falls on the first full week ... owners to cherish the human-animal bond and recognize responsible pet ownership. Pet owners can ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Civilian Corps of the U.S. Army Medical ... that care for its uniformed service members, the retired service members, their families and ... 6th through May 12th National Nurses Week. It acknowledges the hard work and dedication ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... help consumers better understand life insurance throughout various life stages. , The site ... life insurance needs calculator and content specific to the times when life insurance ...
(Date:5/2/2016)... ... May 02, 2016 , ... In honor of National Physical ... incentive to people who share their fitness journey on social media. , The ... products, will award a $100 product voucher each week during May to one winner. ...
(Date:5/2/2016)... ... , ... WestHarbor Growth Partners, a growth, expansion and turnaround ... Healthy Vending’s newly revamped brand campaign. Grow Healthy Vending is headquartered in ... North America with locations across the United States as well as internationally. ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... BERLIN , April 29, 2016 ... world-leading glyco-biology expertise, today announces the appointment of Dr. ... Dr. Zurlo is an oncologist with many years ... pharmaceutical and biotechnology industries. His last role was at ... Member of the Executive Board. Previously Dr. Zurlo held ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s ... complement the company,s valve repair and stent business, ... also places Abbott more firmly into patient monitoring.  ... the fastest growing device areas, with double-digit growth ... recent report,  Advanced Remote Patient Monitoring ...
(Date:4/28/2016)... April 28, 2016 ... George Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter ... heute bekannt, dass neue Führungskräfte zum Team ... sind, die vielfältige Erfahrungen mitbringen.  Dies wird ...
Breaking Medicine Technology: