Navigation Links
Can lowering body temperature prevent brain damage in children who suffer cardiac arrest?
Date:6/11/2009

ANN ARBOR, Mich. In the first large-scale study of its kind, researchers at the University of Michigan's C.S. Mott Children's Hospital and the University of Utah will lead a multi-center study to investigate whether hypothermialowering body temperaturecan prevent or reduce brain damage in children deprived of oxygen after a cardiac arrest.

The Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trials begin this fall. The National Heart, Lung and Blood Institute, part of the National Institutes of Health, will provide funding for the Vanguard phase, and pending successful completion of that phase, for a total of six years of subject accrual from 30 trial sites, and up to 900 participants in the United States and Canada.

Frank W. Moler, M.D., M.S., medical director of the Mott pediatric intensive care unit and professor of pediatrics at the U-M Medical School, is the scientific principal investigator, while J. Michael Dean, M.D., MBA, H.A., and Edna Benning Presidential professor of pediatrics at the University of Utah School of Medicine and Primary Children's Medical Center, Salt Lake City, is principal investigator for the data center.

Every year, thousands of children suffer cardiac arrest as complications from illnesses or as the result of accidents, such as near-drowning.

When the heart stops working during a cardiac arrest, the body's blood supply is interrupted and cells are deprived of oxygen. Brain cells are particularly vulnerable to oxygen loss, leading to sometimes devastating brain damage in children.

"Cardiac arrest in children is a tragic event that usually leads to death, or long term disability in survivors," says Moler. "Currently no therapies have been shown to improve children's chances of recovering."

The THAPCA Trials will look at children who experience cardiac arrest while already hospitalized and have cardiac arrest related to another condition or disease and those who have cardiac arrest after an event or sudden illness outside the hospital.

Children in the trials will be randomly assigned into two actively managed therapy groups: those whose body temperatures will be lowered to 32-34 degrees C through surface cooling called therapeutic hypothermia and those whose body temperatures are actively kept in the normal range 36.0-37.5 degrees C also by surface cooling, sometimes called therapeutic normothermia.

In the initial funding for the Vanguard phase, U-M has received $2.3 million to get the trials underway and the University of Utah has received $1.3 million.

"Performing definitive studies, that allow researchers to examine therapies like therapeutic hypothermia, is challenging because it depends on the cooperation of multiple children's hospitals and significant financial resources," Moler says.


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@med.umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Lowering Blood Protein Wont Help Kidney Patients
3. Abbotts Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study
4. Cholesterol-lowering drug linked to sleep disruptions
5. Many Patients Stop Taking Cholesterol-Lowering Drugs
6. Amount of Exercise Key to Lowering Kids Blood Pressure
7. New Type of Cholesterol-Lowering Drug Shows Promise
8. Lowering Co-Pays on Some Drugs Help Fight Chronic Diseases
9. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
10. Cholesterol-Lowering Statins Tied to Tendon Woes
11. Study shows cholesterol-lowering power of dietitian visits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between Goodwill® and Roadie, ... use or need, from clothes to couches to dressers and bicycles. Roadie — the ... to the nearest Goodwill donation center through February 28th. , “January is an ...
(Date:1/20/2017)... ... 2017 , ... Bionic Sports Nutrition LLC, an American company devoted to developing ... successful January ECRM Trade Show in Hilton Head, SC. , Bionic Sports Nutrition ... provide its products to all clients at reasonable prices. At the ECRM trade show, ...
(Date:1/20/2017)... ... January 20, 2017 , ... Michael and Betsy Brauser celebrated ... Institute. For Betsy, the clinical trial has been life-saving as she has been ... , Betsy Brauser was diagnosed with ovarian cancer in 2009. She underwent standard ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and ... out for each of his children. “The Angel” is the creation of published author, ... New York City, and impassioned writer. , When asked of her new book, Marjorie ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas in ... where she works in a daycare and looks for inspiration in the local coffee ... Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017 The global immunomodulators market is ... according to a new study by Grand View ... predominantly driven by high R&D investments employed by ... of new and therapeutically advanced drugs. This is ... an unprecedented rate into the immunomodulators market hence ...
(Date:1/19/2017)... 2017 Conference Call and Webcast to Follow ... it will release results for the fourth quarter of 2016 on ... ... call at 4:30 PM ET on Wednesday, February 15, 2017, during ... financial results and other corporate activities. To participate in the conference ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
Breaking Medicine Technology: