Navigation Links
Can lowering body temperature prevent brain damage in children who suffer cardiac arrest?
Date:6/11/2009

ANN ARBOR, Mich. In the first large-scale study of its kind, researchers at the University of Michigan's C.S. Mott Children's Hospital and the University of Utah will lead a multi-center study to investigate whether hypothermialowering body temperaturecan prevent or reduce brain damage in children deprived of oxygen after a cardiac arrest.

The Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trials begin this fall. The National Heart, Lung and Blood Institute, part of the National Institutes of Health, will provide funding for the Vanguard phase, and pending successful completion of that phase, for a total of six years of subject accrual from 30 trial sites, and up to 900 participants in the United States and Canada.

Frank W. Moler, M.D., M.S., medical director of the Mott pediatric intensive care unit and professor of pediatrics at the U-M Medical School, is the scientific principal investigator, while J. Michael Dean, M.D., MBA, H.A., and Edna Benning Presidential professor of pediatrics at the University of Utah School of Medicine and Primary Children's Medical Center, Salt Lake City, is principal investigator for the data center.

Every year, thousands of children suffer cardiac arrest as complications from illnesses or as the result of accidents, such as near-drowning.

When the heart stops working during a cardiac arrest, the body's blood supply is interrupted and cells are deprived of oxygen. Brain cells are particularly vulnerable to oxygen loss, leading to sometimes devastating brain damage in children.

"Cardiac arrest in children is a tragic event that usually leads to death, or long term disability in survivors," says Moler. "Currently no therapies have been shown to improve children's chances of recovering."

The THAPCA Trials will look at children who experience cardiac arrest while already hospitalized and have cardiac arrest related to another condition or disease and those who have cardiac arrest after an event or sudden illness outside the hospital.

Children in the trials will be randomly assigned into two actively managed therapy groups: those whose body temperatures will be lowered to 32-34 degrees C through surface cooling called therapeutic hypothermia and those whose body temperatures are actively kept in the normal range 36.0-37.5 degrees C also by surface cooling, sometimes called therapeutic normothermia.

In the initial funding for the Vanguard phase, U-M has received $2.3 million to get the trials underway and the University of Utah has received $1.3 million.

"Performing definitive studies, that allow researchers to examine therapies like therapeutic hypothermia, is challenging because it depends on the cooperation of multiple children's hospitals and significant financial resources," Moler says.


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@med.umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Lowering Blood Protein Wont Help Kidney Patients
3. Abbotts Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study
4. Cholesterol-lowering drug linked to sleep disruptions
5. Many Patients Stop Taking Cholesterol-Lowering Drugs
6. Amount of Exercise Key to Lowering Kids Blood Pressure
7. New Type of Cholesterol-Lowering Drug Shows Promise
8. Lowering Co-Pays on Some Drugs Help Fight Chronic Diseases
9. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
10. Cholesterol-Lowering Statins Tied to Tendon Woes
11. Study shows cholesterol-lowering power of dietitian visits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... Old School ... boxing champ Ashley Theophane as a new Brand Ambassador. Theophane, who trained with Floyd ... welterweight title in 2011. He has racked up an impressive number of wins in ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... solution provider, today announced that its digital marketing solutions have enabled Children’s Hospital ... investment in 24 months. , Recognizing the value of a digital marketing ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... into a research collaboration to translate advances in basic neuroscience at the BMRI ... and beyond. The collaboration seeks to improve movement, vision, and cognition impaired by stroke, ...
(Date:3/22/2017)... Norwich, NY (PRWEB) , ... March 22, 2017 , ... ... to communities in the greater Nassau County region, is embarking on a combined charity ... breast cancer. , For the last 25 years, the Great Neck Breast Cancer ...
(Date:3/22/2017)... NC (PRWEB) , ... March 22, 2017 , ... Chris ... assistance to families and business professionals throughout the coastal plains region, is initiating a ... to overcome cancer. , Dillyn was first diagnosed with leukemia on a Friday evening ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... -- Kalorama Information has noted five news developments in ... industry.  This month the FDA granted a CLIA waiver to ... market has reached $18.4 billion in sales and continues ... battle and the acquisition by Abbott is still in ... chemistry analyzer and researchers evaluated fetal fibronectin screening for ...
(Date:3/22/2017)... , March 22, 2017 NetworkNewsWire Editorial ... ... given differing statements by White House officials. Federal laws are ... marijuana for medical and/or recreational use, and businesses like SinglePoint, ... Inc. (NASDAQ: CRBP), Medical Marijuana, Inc. (OTC: MJNA), Cannabis Science, ...
(Date:3/22/2017)... March 22, 2017  Based on its recent ... & Sullivan recognizes GE Healthcare with the 2016 ... Award. GE Healthcare,s strategy of innovating and expanding ... allowed it to effectively compete in a mature, ... In addition to aiding patient and clinician workflows, ...
Breaking Medicine Technology: