Navigation Links
Can disclosure hurt the translation of research?
Date:9/19/2012

Boston, MA All major clinical trials now include disclosures detailing who funded the study to ensure transparency. However, is it possible that this transparency is actually hurting research? One might assume that the methodological rigor of the study matters to physicians more than the disclosure. However, in a new study, researchers at Brigham and Women's Hospital (BWH) have found that pharmaceutical industry sponsorship of a research study negatively influences physicians' perceptions of the study and their willingness to believe and act on the research findings. This study will be published in the September 20, 2012 issue of the New England Journal of Medicine (NEJM).

"We found that physicians downgraded their perceptions of industry funded research similarly for high-quality studies and low-quality studies," explained Aaron Kesselheim, MD, JD, assistant professor of medicine in the Division of Pharmacoepidemiology and Pharmacoeconomics at BWH, and principal investigator of this study.

The research team presented abstracts describing hypothetical clinical trials of three fictional, but potentially useful, new drugs to a national sample of board-certified internal medicine physicians. Each abstract was randomized to demonstrate high, medium, or low methodological rigor and randomized to report one of three disclosure variables: funding from a pharmaceutical company, funding by the National Institutes of Health (NIH), or no disclosure listed. The investigators then assessed physicians' impressions of the trials' rigor, their confidence in the results, and their willingness to prescribe the drugs.

"We found clear associations between the funding disclosure variations and physicians' perceptions of a trial's rigor and results," explained Dr. Kesselheim.

The results showed that physicians downgraded the credibility of industry-funded trials when compared with the same trials that had no funding listed, and to an even greater extent when compared with the same trials characterized as having NIH funding. The authors attributed these results to high-profile instances of unethical behavior by pharmaceutical companies sponsoring clinical research in the past decade.

Researchers emphasize that these findings have important implications. The pharmaceutical industry funds a substantial portion of clinical research, and a key determinant of the impact of a trial should be its methodological rigor, not its funding source, Dr. Kesselheim and his co-authors argue.

"While there is good reason to be extra vigilant about industry-funded research, if physicians are reluctant to trust all such research, this could hinder the translation of even high-quality industry-funded research into practice. Strategies such as greater transparency and independent review of trial data could be pursued to try to change such attitudes among physicians," Dr. Kesselheim suggested.


'/>"/>

Contact: Jessica Maki
jmaki3@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. Study finds non-disclosure of HIV serostatus common among India female sex workers
2. New federal disclosure law may have little impact on drugs prescribed
3. Penn Translational Medicine Institute to hold 7th Annual Symposium
4. Translation of research into practice for post-stroke care goes national
5. Weill Cornell awarded $1.8 million for translational blood cancer research
6. SU2C, Dutch Cancer Society announce new International Translational Cancer Research Grant recipients
7. U-Ms Taubman Institute awards inaugural $100,000 translational medical research prize
8. TMC institutions get $20 million renewal grant for translational medicine center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... 2016 , ... Trinity Health today launched its inaugural Innovation ... at improving care and reducing readmission rates for patients who are dually eligible ... is to drive innovation that transforms our ministry and our industry to be ...
(Date:5/4/2016)... SCOTTSDALE, AZ (PRWEB) , ... May 04, 2016 ... ... 2016 Annual Technology & Business Conference. The conference opened on Tuesday with Frank ... panel discussion on NCPDP’s PDMP Solution provided a deep dive on NCPDP’s model ...
(Date:5/4/2016)... ... 04, 2016 , ... Level 10 Head Over Heels Athletic Arts’ gymnast Alessandra ... of Arizona for the fall of 2019. , After a handful of college ... the GymCats came from her connection with the coaching staff and the excitement surrounding ...
(Date:5/4/2016)... ... May 04, 2016 , ... IsoComforter, Inc., one of ... the innovative newly improved Iso-Hip Wrap. The newly designed hip wrap has ... comfort and enables the patient to enjoy the benefits of cold therapy while ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nike Rugby Camp's success is ... San Diego. Willis, founder of Elite Rugby Camps and current Nike Camp director, has ... year since 2009. , “I’m excited for our eighth summer here in San ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... May 3, 2016 BioNovus Innovations LLC ... for Advancing Medical Innovation (IAMI) today announced a ... diagnostics and medical devices. An agreement ... rights to license, develop and commercialize medical innovations ... "This partnership represents a significant advance in ...
(Date:5/3/2016)... , May 3, 2016  Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to further expand ... Photo - http://photos.prnewswire.com/prnh/20160503/362921 ... ... ... ...
(Date:5/3/2016)... , May 3, 2016 ACME ... Jack Whelan and Delaware County Councilman ... HCI) Nasal Spray in all ACME pharmacies ... Centers for Disease Control and Prevention (CDC), naloxone has saved 26,463 ... police officers in Delaware County were authorized ...
Breaking Medicine Technology: