Navigation Links
Can breast cancer cells' reaction to cancer drugs be predicted?
Date:11/19/2012

The answer is yes. Finnish researchers have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells. Harnessing genomic profiles of cells in choosing the best treatment is considered the holy grail of personalised medicine.

The team led by Professor Samuel Kaski from Helsinki institute of Information Technology (HIIT), a joint research centre of Aalto University and University of Helsinki, Finland, presented its winning solution at the DREAM 2012 conference on November 13 in San Francisco. The team's solution outperformed 47 other teams in the prediction challenge world-wide.

Computational methods integrate multiple views of the genomic profile of cancer cells

It is well known that drug therapies may effectively kill cancer cells in one patient, but not in another patient suffering from the same type of cancer. However, the molecular determinants underlying the differences in drug response have not so far been sufficiently understood.

  • The goal in computational personalised medicine is to develop models which predict drug sensitivity of cells from their genomic profiles, Kaski explains.

The organisers of the NCI-Dream challenge provided data of breast cancer cells for the training of computational sensitivity prediction models. They evaluated the participants' models on test measurements of drugs that were unknown to the participants.

As in most current biomedical experiments, several types of measurements had been collected on the cancer cells: activity of genes, epigenetics, and genetic profiles. The key problem was to optimally combine the complementary "views" that the different measurements yield.

  • We had been developing new machine learning methods for these 'multi-view' problems, which occur in many fields, and they gave us a flying start, tells Kaski.

  • The challenge was a great additional opportunity for us to put our heads together. People with different backgrounds presented different views on the problem and brought in their own expertise and experience to improve the integrated solution, says HIIT researcher Dr Elisabeth Georgii.

Although the result is still far from clinical applicability, computational personalised medicine has taken an encouraging, prize-winning step forward.


'/>"/>

Contact: Samuel Kaski
samuel.kaski@hiit.fi
358-503-058-694
Aalto University
Source:Eurekalert

Related medicine news :

1. Strong Social Support Seems to Boost Breast Cancer Survival
2. Black Women More Likely to Die From Breast Cancer: Report
3. Heart failure in older breast cancer patients linked to medication
4. Enhancing breast cancer detection
5. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
6. High-quality personal relationships improve survival in women with breast cancer
7. Minimally invasive lymph node dissection in breast cancer has advantages over conventional surgery
8. Acupuncture Might Ease Fatigue Linked to Breast Cancer
9. Eating Meat May Raise Breast Cancer Risk in Whites: Study
10. New finding gives clues for overcoming tamoxifen-resistant breast cancer
11. Combination treatment may improve survival of breast cancer patients with brain metastases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 09, 2016 , ... Ross A. Clevens, MD, ... to welcome a new addition to their growing practice. Beginning this month, Teresa ... nurse practitioner performing cosmetic procedures including injectables, fillers and laser treatments. ...
(Date:2/9/2016)... ... February 09, 2016 , ... Steven Douglas Associates is a ... Florida Event, an upscale fundraiser held in South Florida. The Inaugural What’s Your Taste ... This year the event will be held in a new, more causal format at ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... production of its newest mobility device, the StandUp Walker. Made entirely in the ... in the last 50 years. , StandUp Walker’s novel patent-pending design offers 2-in-1 ...
(Date:2/9/2016)... Springs, FL (PRWEB) , ... February 09, 2016 ... ... leading innovative specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ ... for each prescription referral received at our specialty pharmacy. , “Since our ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Bon-Ton Stores, Inc. (NASDAQ: ... stores, announced it has raised $176,000 to benefit the Breast Cancer Research Foundation, ... at the University of Iowa, The Lynn Sage Cancer Research Foundation, and Masonic ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 9, 2016 On ... Administration (FDA) met with its Arthritis Advisory ... biosimilar of Johnson & Johnson,s Remicade and ... approved in the U.S. The Biologics Prescribers ... groups - Alliance for Patient Access, American ...
(Date:2/9/2016)... Calif. , Feb. 9, 2016 /PRNewswire/ - Nevro ... company that is providing innovative evidence-based solutions for the ... release financial results for the fourth quarter and full ... 29, 2016. Company management will host a conference call ... Time) on Monday, February 29, 2016. www.nevro.com ...
(Date:2/9/2016)... 9, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... today reported its fourth quarter and full year ... vivo therapeutic genome editing," said Edward Lanphier, ... finger nuclease (ZFN) technology leads the therapeutic genome ... competencies necessary to move our ground-breaking genome editing ...
Breaking Medicine Technology: