Navigation Links
Can breast cancer cells' reaction to cancer drugs be predicted?
Date:11/19/2012

The answer is yes. Finnish researchers have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells. Harnessing genomic profiles of cells in choosing the best treatment is considered the holy grail of personalised medicine.

The team led by Professor Samuel Kaski from Helsinki institute of Information Technology (HIIT), a joint research centre of Aalto University and University of Helsinki, Finland, presented its winning solution at the DREAM 2012 conference on November 13 in San Francisco. The team's solution outperformed 47 other teams in the prediction challenge world-wide.

Computational methods integrate multiple views of the genomic profile of cancer cells

It is well known that drug therapies may effectively kill cancer cells in one patient, but not in another patient suffering from the same type of cancer. However, the molecular determinants underlying the differences in drug response have not so far been sufficiently understood.

  • The goal in computational personalised medicine is to develop models which predict drug sensitivity of cells from their genomic profiles, Kaski explains.

The organisers of the NCI-Dream challenge provided data of breast cancer cells for the training of computational sensitivity prediction models. They evaluated the participants' models on test measurements of drugs that were unknown to the participants.

As in most current biomedical experiments, several types of measurements had been collected on the cancer cells: activity of genes, epigenetics, and genetic profiles. The key problem was to optimally combine the complementary "views" that the different measurements yield.

  • We had been developing new machine learning methods for these 'multi-view' problems, which occur in many fields, and they gave us a flying start, tells Kaski.

  • The challenge was a great additional opportunity for us to put our heads together. People with different backgrounds presented different views on the problem and brought in their own expertise and experience to improve the integrated solution, says HIIT researcher Dr Elisabeth Georgii.

Although the result is still far from clinical applicability, computational personalised medicine has taken an encouraging, prize-winning step forward.


'/>"/>

Contact: Samuel Kaski
samuel.kaski@hiit.fi
358-503-058-694
Aalto University
Source:Eurekalert

Related medicine news :

1. Strong Social Support Seems to Boost Breast Cancer Survival
2. Black Women More Likely to Die From Breast Cancer: Report
3. Heart failure in older breast cancer patients linked to medication
4. Enhancing breast cancer detection
5. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
6. High-quality personal relationships improve survival in women with breast cancer
7. Minimally invasive lymph node dissection in breast cancer has advantages over conventional surgery
8. Acupuncture Might Ease Fatigue Linked to Breast Cancer
9. Eating Meat May Raise Breast Cancer Risk in Whites: Study
10. New finding gives clues for overcoming tamoxifen-resistant breast cancer
11. Combination treatment may improve survival of breast cancer patients with brain metastases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... 2017 , ... Neil H. Greco Insurance Agency, a northern New Jersey firm ... is launching a charity drive to raise awareness of heart disease and promote habits ... America, and is responsible for 1 in every 4 deaths at the national level ...
(Date:1/17/2017)... Gatos, CA (PRWEB) , ... January 17, 2017 , ... ... announced the results of a double blind clinical study for its dental gel that ... a leading national brand of toothpaste containing triclosan. The study was conducted at the ...
(Date:1/17/2017)... Tyler, TX (PRWEB) , ... January 17, 2017 ... ... serving Texas families from two offices in Tyler, has announced the latest beneficiary ... Red Ribbon Wish Network, a nonprofit organization dedicated to fulfilling the dreams of ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... Today, ... USA Wrestling announced a new agreement as part of a long-term extension of ... 2024 and includes the airing of some of the sport’s premier events exclusively on ...
(Date:1/16/2017)... ... January 17, 2017 , ... Recently, patients and staff from ... joined other volunteers and organizations in support of the annual Binder Park Zoo Halloween ... dressed up in colorful costumes of all designs coming out to enjoy games, face ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017  Maureen L. ... announces the addition of 6 senior sales leaders ... TubeClear® System.  These sales leaders were formerly part ... medical device company. Repeatedly recognized for their performance, ... customer expectations and establishing relationships with key customer ...
(Date:1/17/2017)... , January 17, 2017 Transparency Market ... Acid, Benzoic Acid, Sodium Benzoate, Benzyl Alcohol and Others) Market - ... to the report, the global benzaldehyde derivative market was ... reach US$ 2.14 Bn by 2024, expanding at a CAGR of ... ...
(Date:1/16/2017)... -- Research and Markets has announced the addition of ... their offering. ... Global multiple myeloma drugs market to grow at a CAGR of ... the present scenario and the growth prospects of the global multiple ... report considers the revenue generated from the sales of branded and ...
Breaking Medicine Technology: