Navigation Links
Can breast cancer cells' reaction to cancer drugs be predicted?
Date:11/19/2012

The answer is yes. Finnish researchers have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells. Harnessing genomic profiles of cells in choosing the best treatment is considered the holy grail of personalised medicine.

The team led by Professor Samuel Kaski from Helsinki institute of Information Technology (HIIT), a joint research centre of Aalto University and University of Helsinki, Finland, presented its winning solution at the DREAM 2012 conference on November 13 in San Francisco. The team's solution outperformed 47 other teams in the prediction challenge world-wide.

Computational methods integrate multiple views of the genomic profile of cancer cells

It is well known that drug therapies may effectively kill cancer cells in one patient, but not in another patient suffering from the same type of cancer. However, the molecular determinants underlying the differences in drug response have not so far been sufficiently understood.

  • The goal in computational personalised medicine is to develop models which predict drug sensitivity of cells from their genomic profiles, Kaski explains.

The organisers of the NCI-Dream challenge provided data of breast cancer cells for the training of computational sensitivity prediction models. They evaluated the participants' models on test measurements of drugs that were unknown to the participants.

As in most current biomedical experiments, several types of measurements had been collected on the cancer cells: activity of genes, epigenetics, and genetic profiles. The key problem was to optimally combine the complementary "views" that the different measurements yield.

  • We had been developing new machine learning methods for these 'multi-view' problems, which occur in many fields, and they gave us a flying start, tells Kaski.

  • The challenge was a great additional opportunity for us to put our heads together. People with different backgrounds presented different views on the problem and brought in their own expertise and experience to improve the integrated solution, says HIIT researcher Dr Elisabeth Georgii.

Although the result is still far from clinical applicability, computational personalised medicine has taken an encouraging, prize-winning step forward.


'/>"/>

Contact: Samuel Kaski
samuel.kaski@hiit.fi
358-503-058-694
Aalto University
Source:Eurekalert

Related medicine news :

1. Strong Social Support Seems to Boost Breast Cancer Survival
2. Black Women More Likely to Die From Breast Cancer: Report
3. Heart failure in older breast cancer patients linked to medication
4. Enhancing breast cancer detection
5. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
6. High-quality personal relationships improve survival in women with breast cancer
7. Minimally invasive lymph node dissection in breast cancer has advantages over conventional surgery
8. Acupuncture Might Ease Fatigue Linked to Breast Cancer
9. Eating Meat May Raise Breast Cancer Risk in Whites: Study
10. New finding gives clues for overcoming tamoxifen-resistant breast cancer
11. Combination treatment may improve survival of breast cancer patients with brain metastases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... ... unique liquid food supplements, announced its popular products are now available for purchase ... ALP Nutrition® prioritizes the use of premium natural ingredients in making all of ...
(Date:4/24/2017)... ... April 24, 2017 , ... symplrTM, a leading provider ... announced that Kyle Allain has joined the company as Vice President and General ... including provider, payor and managed care solutions. , A seasoned executive with ...
(Date:4/24/2017)... ... April 24, 2017 , ... Rod Burkett, CEO of Gardant Management Solutions, was ... has been at the forefront of Gardant since it was founded in 1999. His ... the opening of more than 40 new senior living communities. With his leadership, Gardant ...
(Date:4/24/2017)... Switzerland (PRWEB) , ... April 24, 2017 , ... ... steps to become familiar. This makes it difficult for lab operators and management ... systematic methodology to help them identify wasteful or unnecessary actions. , Created ...
(Date:4/24/2017)... ... April 24, 2017 , ... “Learning to Use Your SPIRITUAL COMPASS To ... to Use Your SPIRITUAL COMPASS To Navigate Life Issues” is the creation of published ... of the Board of Directors for CONTACT USA, and former member of the American ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... -- Cogentix Medical, Inc. (NASDAQ: CGNT), a global medical ... Gynecology markets with innovative and proprietary products, will release ... 2017 after the market close on Tuesday, May 2, ... conference call and webcast to discuss its financial results ... 4:30 p.m. Eastern Time (3:30 p.m. Central Time). ...
(Date:4/18/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 6.35% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/18/2017)... SAN DIEGO and BLOOMINGTON, ... Pharmaceuticals, Inc. (NASDAQ: IMMY ) ("Imprimis"), ... d/b/a Precision Lens ("Precision Lens"), today announced the ... Under the agreement, Precision Lens will deploy a ... into select geographies in the U.S., primarily focused ...
Breaking Medicine Technology: