Navigation Links
Can Celebrex prevent cancer-causing colon polyps?
Date:5/13/2010

Rush University Medical Center is testing whether celecoxib, known by its brand name Celebrex, can help prevent the growth of precancerous polyps that form in the colon, rectum and small intestine of children with an inheritable genetic disease called familial adenomatous polyposis.

In this rare but devastating disease, polyps begin forming in patients as young as 10 years of age and number in the hundreds or even thousands. The disease carries a 100-percent lifetime risk of developing colorectal cancer. By the age of 40, all cases will become malignant unless the colon is removed earlier.

Rush is one of 16 centers throughout the United States, and the only one in Illinois, involved in the international Phase III clinical trial of celecoxib.

"Surgery is currently the standard treatment for this disease, and because the formation of polyps is relentless, patients often require multiple surgeries," said Dr. Marc Brand, a colorectal surgeon at Rush and principal investigator of the study. "Any drug that can prevent the formation of polyps, or even reduce the number of polyps, would be a great help for these patients."

Celecoxib, an anti-inflammatory drug typically used to treat the pain of arthritis, has already been approved by the Food and Drug Administration to suppress polyp formation in the rectum. But its efficacy in other areas of the gastrointestinal tract has not yet been shown. The drug's mechanism of action is not its anti-inflammatory effect but its ability to suppress elevated levels of the COX-2 enzyme, which are found in the precancerous lesions but not in normal colorectal tissue.

A total of 200 patients, ages 10 to 17, who have been genetically tested for the disease will be enrolled in the study. Half the group will receive the drug and half a placebo. Researchers will assess whether the drug is effective in preventing the formation of polyps over a five-year treatment period.


'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Celebrex Might Thwart Inherited Skin Cancers
2. Calcium in early life may prevent obesity later
3. Prevention Program Spares Seniors More Falls
4. DTWI's Travel Carbon Monoxide Detector Prevents Carbon Monoxide Poisoning Whilst Holidaying Abroad, or in the UK
5. Prevention Gets Credit for Fewer Heart Deaths
6. Preventing blindness focus of ORNL technology, AMDx
7. Stool DNA testing could play expanded role in colon cancer prevention
8. Lab Industry Likely to Benefit from Expanded Preventive Testing Under New Health Care Law
9. Surgeons pilot prevention program reduces incidence of postoperative pneumonia
10. Cells programmed to cure and even prevent cancer
11. UGA, Emory to study how exercise may prevent drug abuse relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
(Date:10/20/2014)... October 20, 2014 The Advocator ... booth at the American Foundation for Suicide Prevention’s (AFSP) ... AFSP is a not-for-profit organization that hosts hundreds of ... from these events are used to help understand and ... and personal relationships as well. , The Advocator ...
(Date:10/20/2014)... 20, 2014 Women’s health specialist, Dr. ... & Gynecology of Columbus, Inc., A Division of MaternOhio ... to more than 100,000 patients annually. Dr. Murphy will ... and stages of a women’s life. She is accepting ... in Westerville and Dublin. , Dr. Murphy offers a ...
(Date:10/20/2014)... 2014 hc1.com today announced the ... solution that enables healthcare organizations of all sizes ... customer relationship management (“CRM”) solution. , Designed from ... of the healthcare industry, the hc1 Healthcare Relationship ... patients by combining healthcare CRM, HIPAA-compliant collaboration, and ...
(Date:10/20/2014)... CA (PRWEB) October 20, 2014 JZ ... expertise, nutritional coaching, corporate wellness programming, authorship, international lecturing ... is excited to announce the release of the JZ ... After many years of coaching thousands of individuals on ... tracking app that does not require calorie counting or ...
Breaking Medicine News(10 mins):Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3
... MARCOS, Calif., March 9 Natural Alternatives International, Inc. ... formulator and manufacturer of customized nutritional supplements, and ... based distributor of raw materials to the sports ... industries, today jointly announced their licensing agreement of ...
... and BOGOTA, March 9 /PRNewswire/ -- ... a Service providers, has contracted with Columbian-based ETEK International ... and Latin American markets. One of South America,s ... security and professional services which include, among others, Intrusion ...
... Third Quarter Results on April 2, 2009 ... Inc. ("Allscripts") announced today that it has ... Medication Services business to A-S Medication Solutions ... transaction, which is anticipated to generate total ...
... Brookdale Senior Living Inc. (NYSE: BKD ... Officer, and Mark Ohlendorf, Co-President and Chief Financial Officer, ... Barclays Capital Global Healthcare Conference in Miami Beach, Florida ... Eastern Time.The presentation is being audio webcast live and ...
... In Kentucky, nearly one out of every two of ... a quarter of the dentists accept the insurance; therefore ... it comes to seeing a dentist or receiving dental ... Healthcare, manufacturer of Aquafresh(R) and Sensodyne(R), has donated 10,000 ...
... , , MONDAY, March 9 (HealthDay News) -- If you think ... be all in your head. , Harvard researchers report ... visit emergency rooms with migraines if the outside temperature is ... is not as significant. , The findings do not definitively ...
Cached Medicine News:Health News:Natural Alternatives International, Inc. Announces Carnosyn(R) Beta-Alanine Licensing Agreement 2Health News:Natural Alternatives International, Inc. Announces Carnosyn(R) Beta-Alanine Licensing Agreement 3Health News:Natural Alternatives International, Inc. Announces Carnosyn(R) Beta-Alanine Licensing Agreement 4Health News:SecureWorks Partners With ETEK International to Provide Security Services to the South American and Latin American Markets 2Health News:Allscripts to Sell Its Medication Services Business to A-S Medication Solutions, Sign Joint Marketing Agreement 2Health News:Allscripts to Sell Its Medication Services Business to A-S Medication Solutions, Sign Joint Marketing Agreement 3Health News:Allscripts to Sell Its Medication Services Business to A-S Medication Solutions, Sign Joint Marketing Agreement 4Health News:GlaxoSmithKline Consumer Healthcare Helps to Bridge Oral Care Gap in Appalachia 2Health News:Warmer-Than-Average Temperatures Raise Migraine Risk 2Health News:Warmer-Than-Average Temperatures Raise Migraine Risk 3
(Date:10/17/2014)... October 17, 2014 ... has announced the addition of the  "China ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... in China impacted ... in consumption concept, dietary habit, way of ...
(Date:10/17/2014)... October 17, 2014 ... Market by Technique (Optical Coherence Tomography, Hyperspectral ... Application (Ophthalmology, Neurology, Oncology, Cardiology) - Global ... studies the Optical Imaging market over the ... valued at $917.1 million in 2014 and ...
(Date:10/17/2014)... Oct. 17, 2014 A victim of medical negligence ... doctor with a history of alcohol abuse, a physician ... on Prop 46 today, highlighting how Prop 46 will identify ... testing. The ad pictures a doctor drinking ... To ER."  Proposition 46 will enact the first law in ...
Breaking Medicine Technology:China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4
... ORANGE, N.J., July 13, 2011 Kessler Foundation ... ( www.kessler-rehab.com ) are the first rehabilitation centers ... V6, an advanced robotic training system designed to ... brain injury, stroke, multiple sclerosis or other neurological ...
... NEW YORK, July 13, 2011 ACCESS PHARMACEUTICALS, ... biopharmaceutical company leveraging its proprietary drug-delivery platforms to develop treatments ... announced that it has signed an agreement to restructure ... year. The amended agreement provides for extension of 50% of ...
Cached Medicine Technology:Kessler is the First Rehabilitation Center in the Nation to Use New Robotic Gait Training System 2Kessler is the First Rehabilitation Center in the Nation to Use New Robotic Gait Training System 3Access Pharmaceuticals Announces Restructuring of Outstanding Senior Convertible Note 2Access Pharmaceuticals Announces Restructuring of Outstanding Senior Convertible Note 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: