Navigation Links
Can Celebrex prevent cancer-causing colon polyps?
Date:5/13/2010

Rush University Medical Center is testing whether celecoxib, known by its brand name Celebrex, can help prevent the growth of precancerous polyps that form in the colon, rectum and small intestine of children with an inheritable genetic disease called familial adenomatous polyposis.

In this rare but devastating disease, polyps begin forming in patients as young as 10 years of age and number in the hundreds or even thousands. The disease carries a 100-percent lifetime risk of developing colorectal cancer. By the age of 40, all cases will become malignant unless the colon is removed earlier.

Rush is one of 16 centers throughout the United States, and the only one in Illinois, involved in the international Phase III clinical trial of celecoxib.

"Surgery is currently the standard treatment for this disease, and because the formation of polyps is relentless, patients often require multiple surgeries," said Dr. Marc Brand, a colorectal surgeon at Rush and principal investigator of the study. "Any drug that can prevent the formation of polyps, or even reduce the number of polyps, would be a great help for these patients."

Celecoxib, an anti-inflammatory drug typically used to treat the pain of arthritis, has already been approved by the Food and Drug Administration to suppress polyp formation in the rectum. But its efficacy in other areas of the gastrointestinal tract has not yet been shown. The drug's mechanism of action is not its anti-inflammatory effect but its ability to suppress elevated levels of the COX-2 enzyme, which are found in the precancerous lesions but not in normal colorectal tissue.

A total of 200 patients, ages 10 to 17, who have been genetically tested for the disease will be enrolled in the study. Half the group will receive the drug and half a placebo. Researchers will assess whether the drug is effective in preventing the formation of polyps over a five-year treatment period.


'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Celebrex Might Thwart Inherited Skin Cancers
2. Calcium in early life may prevent obesity later
3. Prevention Program Spares Seniors More Falls
4. DTWI's Travel Carbon Monoxide Detector Prevents Carbon Monoxide Poisoning Whilst Holidaying Abroad, or in the UK
5. Prevention Gets Credit for Fewer Heart Deaths
6. Preventing blindness focus of ORNL technology, AMDx
7. Stool DNA testing could play expanded role in colon cancer prevention
8. Lab Industry Likely to Benefit from Expanded Preventive Testing Under New Health Care Law
9. Surgeons pilot prevention program reduces incidence of postoperative pneumonia
10. Cells programmed to cure and even prevent cancer
11. UGA, Emory to study how exercise may prevent drug abuse relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... “Every three months the trends for ... evening dress will be one of the hottest styles in ... says. Today, the company releases 26 A-line sweetheart evening dresses, ... off. , “We are trying our best to help ... latest designs. Along with affordable prices, we provide discounted delivery ...
(Date:12/25/2014)... Los Angeles, CA (PRWEB) December 25, 2014 ... Blaise Dolcemaschio was created in honor of a true ... premiere at two film festivals including the 24 hours of ... Film Festival in Bangladesh. , Actress, screenwriter and ... and helped produce this film together with her husband, ...
(Date:12/25/2014)... Helen Harris’ RP (Retinitis Pigmentosa) International founder ... an 8 year battle with breast cancer. , ... her home in Woodland Hills California after an 8 ... , As the founder and volunteer President of ... championed many of today's greatest breakthroughs in restoring and ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... children with complex chronic illnesses can receive effective, less expensive ... with easy access to a team of dedicated health care ... to become seriously ill and need either hospitalization or a ... an enhanced medical home clinic at the University of Texas ...
(Date:12/25/2014)... -- Among early stage breast cancer patients who undergo ... percent will eventually develop leukemia as a result of ... comes from a review of more than 20,000 breast ... suggests that the risk for developing treatment-related leukemia, though ... "The frequency of bone marrow cancers such as ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... CST-Arwin will represent the complete AC and DC line of axial ... more than 100 axial fans ranging in size from 25mm to ... ... -- NMB Technologies Corporation, a Minebea Group Company, and CST-Arwin, a ...
... WASHINGTON, DC, November 3, 2008 Parents are surprisingly ... visit to their child,s pediatrician, including those who have ... would look to their pediatrician for a referral, according ... the journal Pediatrics . , "This is a ...
... 3, 2008) Influenza vaccination rates for adolescents who suffer ... low, according to a recent study. , ... Pediatrics, was based at the Department of ... Harvard Pilgrim Health Care. , "Influenza vaccination has been ...
... RAMSEY, N.J., Nov. 3 Konica Minolta ... the industrial measurement of color,light and shape, ... Analysis Software.,This new software product used in ... accurate measurement of skin,color simultaneously with a ...
... two-pronged attack, a novel designer molecule fights malignant melanoma. It ... led by the University of Bonn. On the one hand, ... this way alerts the immune system. The body,s own defences ... the same time, the novel molecule also puts pressure on ...
... to Ask Voters ... of Health Care, TRENTON, N.J., Nov. 1 Calling themselves ... forces to ask the state,s public policy makers to put health ... level. The First Ladies,joined the newest members of the Partnership to ...
Cached Medicine News:Health News:NMB's Fans and Blowers to be Represented in Canada by CST-Arwin 2Health News:Parents comfortable with alcohol screening in pediatricians' offices 2Health News:Parents comfortable with alcohol screening in pediatricians' offices 3Health News:Flu vaccination rates lag for at-risk adolescents 2Health News:Konica Minolta Sensing Americas Announces the Launch of the CM-SA Skin Analysis Software 2Health News:Substance tackles skin cancer from 2 sides 2Health News:On Weekend Before the Election, New Jersey's First Ladies Speak Out for Healthcare 2Health News:On Weekend Before the Election, New Jersey's First Ladies Speak Out for Healthcare 3
(Date:12/24/2014)... PHILADELPHIA , Dec. 23, 2014 ... a medical device company focused on skin permeation, ... that Scott W. Hollander has been ... Mr. Hollander has more than 20 years of ... equipment industries, and most recently served as Vice ...
(Date:12/24/2014)... 23, 2014 ResMed (NYSE: RMD ) ... against Chinese medical device manufacturer BMC Medical Co., Ltd. ... BMC,s masks listed below infringe ResMed,s patents, and entered an ... in the United States : ... , Willow nasal pillows mask , iVolve full ...
(Date:12/24/2014)... 2014   Synageva BioPharma Corp. (NASDAQ: ... therapeutic products for rare disorders, today announced validation ... Marketing Authorization Application (MAA) for sebelipase alfa for ... request for accelerated assessment, which has the potential ... The MAA, and the Biologics License ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... from Mayo ClinicROCHESTER, Minn., March 23 Here ... Edge, Mayo Clinic,s research magazine. You may cite ... you wish. Reprinting is allowed with proper attribution. ... editorial policies permit: Visit http://discoverysedge.mayo.edu for ...
... Since 1993, when the PLCO trial was started, we have ... have others. The initial report of the results of this ... published last week in the New England Journal of Medicine ... The studies offer conflicting evidence about the possibility of a ...
Cached Medicine Technology:Discovery's Edge Spring Issue - http://discoverysedge.mayo.edu 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 3
Microalbumin Linearity Control...
Total IgE Control...
The K-ASSAY Lipid Controls are assayed controls produced from fresh human sera to monitor the accuracy and precision of quantitative lipid determinations of human sera specimens....
The K-ASSAY hs-CRP Control Set is intended to be used as a consistent test sample of known concentrations for monitoring the performance of hs-CRP (high sensitive C-Reactive Protein) immunoturbimetri...
Medicine Products: