Navigation Links
Can Blood Test Predict Breast Cancer Risk?
Date:5/1/2012

TUESDAY, May 1 (HealthDay News) -- A blood test that spots changes in a specific gene could reveal a woman's risk for breast cancer years before the disease has a chance to develop, researchers report.

British scientists analyzed blood samples from 640 breast cancer patients and 741 women without breast cancer. The samples from the breast cancer patients were collected an average of three years before they were diagnosed with the disease.

The objective was to find out if the alteration of single genes by a process called methylation could predict a woman's breast cancer risk.

The researchers found that women with the highest level of methylation on one area of a gene called ATM were two times more likely to develop cancer than those with the lowest level of methylation. Methylation is a critical process where chemicals known as "methyl groups" are added to DNA, to make sure everything is in good working order. High levels of methylation signal high levels of DNA trouble.

This result was particularly pronounced in blood samples taken from women under the age of 60, Dr. James Flanagan, a Breast Cancer Campaign scientific fellow in the department of surgery and cancer at Imperial College London, said in a news release from the Breast Cancer Campaign.

The study was published May 1 in the journal Cancer Research.

Unlike previous studies that took blood from breast cancer patients after diagnosis, these blood samples identified alterations in the ATM gene that did not occur because of having active cancer or cancer treatments.

The findings provide strong evidence that looking for this type of alteration in individual genes could be used as a blood test to help predict a woman's chances of developing breast cancer, the researchers said.

Used in combination with other breast cancer risk assessment tools such as genetic testing and risk factor profiling, this blood test could help identify women at higher risk. This early warning could be used to monitor these patients and one day perhaps even prevent them from developing breast cancer.

"We know that genetic variation contributes to a person's risk of disease. With this new study, we can now also say that epigenetic variation, or differences in how genes are modified, also has a role," Flanagan said.

"We hope that this research is just the beginning of our understanding about the epigenetic component of breast cancer risk, and in the coming years we hope to find many more examples of genes that contribute to a person's risk. The challenge will be how to incorporate all of this new information into the computer models that are currently used for individual risk prediction," he noted.

"So far, we have found alterations in one small region of a gene that appear to associate with risk of disease, and so the next step with this epigenetic research is a genome-wide approach to try and find all the associated genes," Flanagan explained.

More information

The American Cancer Society has more about breast cancer risk factors.

-- Robert Preidt

SOURCE: Breast Cancer Campaign, news release, May 1, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blood Clot Risk for Outpatients Needs More Attention: Study
2. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
3. Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
4. Additional blood pressure screening may reduce incidence of CVD events and death by up to 3 percent
5. Exercise May Help Patients With High Blood Pressure Live Longer
6. Diabetes Groups Issue New Guidelines on Blood Sugar
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Researchers Develop Blood Test for Depression
9. Changes in gene expression may help explain high blood pressure in pregnancy
10. High Blood Pressure May Be Especially Lethal for Blacks
11. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Can Blood Test Predict Breast Cancer Risk?
(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... ... ... PurhealthRX , a leading Health and Nutrition Company, is announcing the ... spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the amount ... into liquid products, while reducing costs to end users. , The team of researchers ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... CHICAGO , Oct. 11, 2017  Hill-Rom Holdings, ... its Aspen Surgical facility in Las Piedras, ... surgical scalpels and blades. ... confirmed that the facility sustained minor structural damage, temporary ... Hurricane Maria. Repairs have been completed, manufacturing operations have ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017  According to the Centers for ... the end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the ... as mandated by certain health insurance regulations. ... The best time to get a flu shot is by the ...
Breaking Medicine Technology: