Navigation Links
Caltech scientists uncover structure of key protein in common HIV subgroup
Date:4/2/2010

rystallize the protein. That was no easy task. Turns out, says Diskin, the protein itself is not stiff enough for crystallization. And so the researchers created a complex of molecules consisting of a gp120 monomer, a CD4 receptor, and an anti-HIV antibody known as 21c.

This configuration facilitated crystallization, and allowed the scientists to look not only at gp120which, indeed, "looks pretty much the same in clade C as in clade B," says Diskinbut to visualize the entire binding site and to see how the various components in the complex interact with one another.

That was when they noticed something unusual: Antibody 21c was not only reacting toand thus making contact withthe gp120 protein sticking out from HIV's envelope, but also was reacting to the CD4 receptors on the body's own T cells. It is the first time this sort of polyreactivitya response to more than one antigenhad been visualized in the 3-D structure of an HIV-targeting antibody.

"The most interesting aspect of our structure is the unexpected contact between the antibody and CD4," says Pamela Bjorkman, the Max Delbruck Professor of Biology at Caltech, a Howard Hughes Medical Institute investigator, and the Caltech team's leader. "The binding to CD4 suggests that this class of anti-HIV antibodies has autoreactive properties, which raises many interesting questions about how anti-HIV immune responses affect an HIV-infected individual."

Does this autoreactivity mean that 21c is too dangerous to work with, because clinicians might be courting a potential autoimmune response with a vaccine that elicits 21c-like antibodies?

Not necessarily, says Diskin.

"Other data out there show that some of the best neutralizing antibodies are also autoreactive," he explains.

What it does mean, however, is that there would be additional hurdles to overcome in eliciting such antibody responses, Diskin says. The body tends to eliminate autoreactive antibodies
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
2. Scientists ID a protein that splices and dices genes
3. Breakthrough by Danish scientists in preventing maternal malaria
4. NIH scientists identify maternal and fetal genes that increase preterm birth risk
5. UM School of Medicine scientists find new malaria vaccine is safe and protective in children
6. Gladstone scientists identify target that may reduce complications of obesity
7. Scientists map out regulatory regions of genome, hot spots for diabetes genes
8. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
9. Scientists discover enzyme that cleans cancer cells
10. Scientists Decode Brain Cancer Cell Line
11. Scientists show how molecular switch helps pancreatic cancer beat drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech scientists uncover structure of key protein in common HIV subgroup
(Date:6/30/2015)... ... June 30, 2015 , ... Trenton Health Team has ... first Medicaid Accountable Care Organizations (ACO) in the State, serving the greater Trenton community. ... The Trenton Health Team ACO draws on the collaborative structure of THT, bringing together ...
(Date:6/30/2015)... ... June 30, 2015 , ... According to a recent report by the ... heroin-related deaths more than tripled in the same period—leading a majority of law enforcement ... Center , a leading Florida-based drug treatment facility, asserts that these heroin statistics point ...
(Date:6/30/2015)... ... June 30, 2015 , ... Broadway by the Sea posted its ... and family member testimonials. Medicare rated the care center as a five-star location based ... video to give future patients a firsthand look at the facility’s satisfied residents. ...
(Date:6/30/2015)... ... June 30, 2015 , ... From the moment a ... wowed with the incredible care that they receive and the luxury in which they ... but now they are proud to offer the same experience, just better! , Their ...
(Date:6/30/2015)... ... 2015 , ... MJH Associates today welcomed Jim ... & Analytics , a consultative healthcare market research practice that is part of ... offers quantitative and qualitative, custom and multi-client primary market research services to support ...
Breaking Medicine News(10 mins):Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 2Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:Broadway by the Sea Video Promotes Top Quality Service 2Health News:NJ Top Dentist, Dr. Laurence C. Breiterman is Now Offering the WOW Factor at His Highly Regarded Dental Practice 2Health News:NJ Top Dentist, Dr. Laurence C. Breiterman is Now Offering the WOW Factor at His Highly Regarded Dental Practice 3Health News:NJ Top Dentist, Dr. Laurence C. Breiterman is Now Offering the WOW Factor at His Highly Regarded Dental Practice 4Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 3
... Choices ( http://www.nhs.uk ), the,online ,front door, to ... to,help people make sense of the stories appearing ... headlines, on NHS Choices,( http://www.nhs.uk/News/Pages/NewsIndex.aspx ), is an ... The service explains the,facts behind newspaper headlines and ...
... Study finds spouses die sooner in unions where anger is ... the secret to a long marriage is communication, and new ... life. , A lengthy study of Midwestern couples finds that ... than the perennially resentful. The couples with the most unexpressed ...
... AT RECEPTION 5:30 PM WED., FEB. 13 AT MARRIOTT,ADDRESS ... WVAADC, LEGISLATIVE LEADERS, AND CRC HEALTH GROUP CEO ... Four-Star General,Barry McCaffrey (ret.), the former White House ... expert in the national media, will,spearhead a Feb. 13-14 ...
... a unique opportunity for ECNP-members to support young ... Research Grants for Young Scientists each year. Each ... 50,000. , The objective of the grant is ... young scientists in neuropsychopharmacology and/or closely related disciplines ...
... - Bradmer Pharmaceuticals Inc.,a biopharmaceutical company dedicated to ... that Dr. Alan M.,Ezrin, President and Chief Executive ... and panelist at the 10th Annual BIO CEO ... on the Company,s,preparations for the planned Phase III ...
... announced today that Michael Davis, a neuroscientist at Emory ... of the Edward M. Scolnick Prize in Neuroscience. The ... to recognize an individual who has made outstanding advances ... the Robert W. Woodruff Professor of Psychiatry and Behavioral ...
Cached Medicine News:Health News:Mutual Resentment in Marriage Can Be Deadly 2Health News:Mutual Resentment in Marriage Can Be Deadly 3Health News:4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, and Dr. Barry Karlin, Nation's #1 Drug Treatment Provider, to Spearhead Drug Treatment WVA Advocacy Day Feb 13-14; 142,000 Need, Don't Get Treatment in State 2Health News:Bradmer to present at the 10th Annual BIO CEO & Investor Conference 2Health News:MIT's McGovern Institute honors Emory neuroscientist for contributions to psychiatry 2
(Date:6/30/2015)...  IGI Laboratories, Inc. (NYSE MKT: IG), a ... company, today announced it has submitted its fifth abbreviated ... Drug Administration (FDA) of 2015, which brings the Company,s ... FDA to twenty-seven. Jason Grenfell-Gardner , ... our current pipeline of twenty-seven submissions, exclusive of our ...
(Date:6/30/2015)...  A new report released today from the Institute ... education and training opportunities to reduce barriers to the ... Annual rates of CPR and AED use by bystanders ... United States even though evidence indicates that ... Red Cross strongly supports the IOM,s recommendation to encourage ...
(Date:6/30/2015)... VALLEY, Pa. , June 30, 2015 /PRNewswire/ ... and delivering innovative solutions for medical and surgical ... is guaranteeing next-day replacements for surgical equipment at ... product manufacturer to offer this type of guarantee. ... Olympus Full Service Agreement earlier this year. ...
Breaking Medicine Technology:IGI Laboratories, Inc. Announces Fifth ANDA Submission Of 2015 2New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 2New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 3New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 4Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 2Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 3
... 2011 Cardinal Health today announced that its board of directors ... on April 15 to shareholders of record on April 1. This ... About Cardinal Health Headquartered in ... a $99 billion health care services company that improves ...
... ANGELES, Feb. 1, 2011 A breakthrough in stroke ... in stroke survivors has published today. In the February ... the first human results of a new method ... reported. Rapid improvement in impaired motor function, gait, hand ...
Cached Medicine Technology:Cardinal Health Declares Regular Quarterly Dividend 2Inflammation Identified as New Therapeutic Target Years After Stroke 2
DAVINCI® performs all required steps primary tube sampling, reagent dispensing, microplate incubation, washing and optical reading....
... contains 266 amino acids and is variably N-glycosylated. ... estimates of between 43 and 56 kDa. Insulin-like ... with high affinity but do not bind insulin. ... characterized at this time, IGFBP-3 has been shown ...
... detection and semi-quantitation of ... antigen in serum as ... diagnosis of autoimmune disease. ... performed either manually or ...
Qualitative EIA for SS-A, SS-B, Sm, Sm/RNP plus Scl-70 and Jo-1...
Medicine Products: