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Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
Date:12/2/2009

e its slowest step even slower," he says. "If we can slow down ubiquitin ligases enough, they may become too slow to get their job doneto build chainsin the time available to them to do so. Being able to develop drugs to block their function would open up a new frontier in medicine."

"We were able to invent HIV therapeutics because we understand how reverse transcriptase works," adds Pierce. "The same applies here. We need to understand how these enzymes work if we're ever going to be able to target them with therapeutics."


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Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

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Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
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