Navigation Links
Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
Date:12/2/2009

PASADENA, Calif.Researchers from the California Institute of Technology (Caltech) have been able to view in detail, and for the first time, the previously mysterious process by which long chains of a protein called ubiquitin are added by enzymes called ubiquitin ligases to proteins that control the cell cycle. Ubiquitin chains tag target proteins for destruction by protein-degrading complexes in the cell.

"We found that ubiquitin ligases build ubiquitin chains very rapidly by transferring ubiquitins one at a time," says Raymond Deshaies, professor of biology at Caltech and Howard Hughes Medical Institute investigator.

Their findings, and the innovative process by which they were obtained, are described in this week's issue of the journal Nature.

Ubiquitin is one of nature's most unusual proteins. Unlike most of its protein brethren, ubiquitin has to be physically attached to other proteins to do its job.

"As its name implies, ubiquitin is found in essentially every kind of eukaryotic cell," says Caltech graduate student Nathan Pierce, the Nature paper's lead author.

In their Nature paper, the Caltech team looked at the process of ubiquitylation, the method by which ubiquitin and ubiquitin chains are added to target proteins. The target proteins used in the study, cyclin E and β-Catenin, are both involved in controlling the cell cycle.

It was already known, Pierce explains, that the addition of a chain of four or more ubiquitins to a target protein marks that protein for annihilation. The destruction of cyclin E is critical for the accurate replication of DNA, while the degradation of β-Catenin keeps cells from dividing during development at the wrong time. If β-Catenin is not degraded, cells proliferate excessively and become predisposed to tumorigenesis. Meanwhile, cells that don't degrade cyclin E accumulate DNA damage and mutations, which can help fuel the unchecked
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Caltech chemists say antibody surrogates are just a click away
2. Caltech engineers build first-ever multi-input plug-and-play synthetic RNA device
3. Vanderbilt scientists report first effective medical therapy for rare stomach disorder
4. Childrens Hospital Oakland scientists discover soy component may be key to fighting colon cancer
5. BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinsons research
6. Scientists find molecular trigger that helps prevent aging and disease
7. Chinese Scientists Develop Database on the Liver
8. Scientists Grow New Penile Tissue in the Lab
9. Social Network for Translational Scientists Launched
10. Antipsychotic Medications Cause Substantial Weight Gain in Children and Adolescents, According to Scientists at the Feinstein Institute for Medical Research and Zucker Hillside Hospital
11. Physical scientists at Arizona State University will apply laws of physics in cancer fight
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
(Date:9/1/2015)... ... September 01, 2015 , ... According to a study published August ... that participated in a three year study about weight loss and diabetes were far ... elected weight loss surgery at the onset of the trial. In fact, the participants ...
(Date:9/1/2015)... ... , ... Celebrity hairstylist and Beauty Gives Back Art Team member Ted Gibson ... Thursday, Oct. 1, at the La Valencia Hotel. The presentation, on the eve of ... and professional hair, makeup and nail design. , The evening of beauty and ...
(Date:9/1/2015)... ... September 01, 2015 , ... Georgia State ... universities across the country in stemming sexual assaults on their campuses. , The ... a consortium of sexual assault researchers and student affairs professionals responding to calls ...
(Date:9/1/2015)... CA (PRWEB) , ... September 01, 2015 , ... ... computing and collaboration, announces Splashtop Business for Remote Support , a solution ... support solution. Unhappy with the escalating renewal prices and inadequate customer services ...
(Date:9/1/2015)... ... 2015 , ... OncLive® today announced it is ... World Report, to provide breaking news and information about the hospital’s pioneering research ... which provides oncologists resources and information?they need to deliver the best care for?their?patients, ...
Breaking Medicine News(10 mins):Health News:Recent Journal Article on Diabetes Remission Adds to the Growing Pile Of Evidence in Favor of Bariatric Surgery, Says Dr. Feiz and Associates 2Health News:Celebrity Hairstylist Ted Gibson Explores Fusion of Fashion and Beauty at “Beauty Behind the Fashion” at Fashion Week San Diego Proceeds to benefit THIRST Project 2Health News:Celebrity Hairstylist Ted Gibson Explores Fusion of Fashion and Beauty at “Beauty Behind the Fashion” at Fashion Week San Diego Proceeds to benefit THIRST Project 3Health News:Georgia State, Partners Introduce Climate Survey to Aid in Preventing Campus Sexual Assaults 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 4Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 2Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 3
... Patients on immunosuppressants should seek medical attention at ... 2008 A new Mayo,Clinic study finds that ... multiple,immunosuppressive medications for inflammatory bowel disease have a ... in this month,s,issue of Gastroenterology., More than ...
... DIEGO, April 2, 2008 Naviscan PET Systems, a,privately ... announced today that a contract has been signed to ... D. Anderson Cancer Center in,Houston. Naviscan,s PEM Flex(TM) Solo ... since the second quarter of 2007., M. D. ...
... Honored by National Science Board and,Council on Foundations ... Bayer Corporation,the health care, nutrition and innovative materials ... will be honored, respectively,by the National Science Board ... of science education and science literacy at two,separate ...
... April 2, 2008 /PRNewswire/ - The latest health data ... lag the,nation and benchmark cities when it comes to ... indicators based on information,from a 2006 report from the ... http://www.pittsburghtoday.org, the Pittsburgh Regional Indicator,project web site., ...
... of Health, Take off Pounds to ... Gain Healthier Lives, NEW ... difference people can make when they join together to confront a,serious challenge. ... Ian Smith, Patti LaBelle, Yolanda Adams, Michael Strahan,Steve Harvey and other leaders ...
... PocketCPR(TM), an FDA-cleared, palm-sized device that assists a ... resuscitation (CPR) chest compressions will be ... or hands-only cardiopulmonary resuscitation (CPR), to ... Arizona. (Photo: http://www.newscom.com/cgi-bin/prnh/20080402/NEW076 ), ...
Cached Medicine News:Health News:Mayo Clinic Identifies Infection Risks for Patients with Inflammatory Bowel Disease 2Health News:Bayer to Receive Two Top National Awards for Its Science Education, Science Literacy Work 2Health News:Bayer to Receive Two Top National Awards for Its Science Education, Science Literacy Work 3Health News:Bayer to Receive Two Top National Awards for Its Science Education, Science Literacy Work 4Health News:Bayer to Receive Two Top National Awards for Its Science Education, Science Literacy Work 5Health News:Bayer to Receive Two Top National Awards for Its Science Education, Science Literacy Work 6Health News:Pittsburghers Slow to Quit 2Health News:50 Million Pound Challenge Marks 1st Anniversary - What a Difference a Year Makes! 2Health News:50 Million Pound Challenge Marks 1st Anniversary - What a Difference a Year Makes! 3Health News:50 Million Pound Challenge Marks 1st Anniversary - What a Difference a Year Makes! 4Health News:State of Arizona to Use PocketCPR for Training Initiative on Hands-Only CPR 2
(Date:9/1/2015)... and OR YEHUDA, Israel , Sept. ... HTWR ), a leading innovator of less invasive, ... of advanced heart failure, announced today that it has ... Cardio, Ltd . ("Valtech").  Valtech is a privately held ... and transcatheter valve repair and replacement devices for the ...
(Date:9/1/2015)... Ark. , Sept. 1, 2015 NOWDiagnostics Inc., based ... its acquisition of ZBx Corporation of Canada ... its vision of a world where people have greater ... manufactures and sells a line of unique blood-based rapid ... highly accurate tests for a variety of ailments and ...
(Date:9/1/2015)... Sept. 1, 2015 Emerus Holdings, a ... emergent, inpatient and diagnostic care in partnership with ... a definitive agreement to receive a strategic investment ... a leading health care investment firm. ... patient-centric acute episodic and ambulatory clinical services to ...
Breaking Medicine Technology:HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 2HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 3HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 4HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 5HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 6HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 7HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 8HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 9HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 10NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 2Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 3
... , SAN CARLOS, Calif., ... today announced the promotion of Lorianne Masuoka, M.D. to ... Masuoka will report directly to Nektar,s President and Chief ... outstanding leadership and highly effective clinical development strategies have ...
... TORONTO, Nov. 30 The Special Committee of Independent Directors ... JLL Partners, Inc. and its affiliate, JLL Patheon Holdings, LLC ... entered into a settlement agreement in respect of the pending ... provides among other things that: , until March 2011, ...
Cached Medicine Technology:Nektar Therapeutics Promotes Lorianne Masuoka, M.D. to Senior Vice President and Chief Medical Officer 2Nektar Therapeutics Promotes Lorianne Masuoka, M.D. to Senior Vice President and Chief Medical Officer 3Patheon and JLL Partners Announce Litigation Settlement 2Patheon and JLL Partners Announce Litigation Settlement 3
... a whole blood hematology control manufactured specifically ... 120, and the Coulter AcT5diff instruments. The ... white cell differential, positioning the populations within ... systems. The product offers 105-day closed-vial stability ...
... assayed hematology control, offers complete assay values ... with the Coulter GENS, STKS, MAXM and ... stability, 105-day closed-vial stability and is available ... 4.0ml pierceable cap vial is compatible with ...
Abiomed introduces its new intra-aortic balloon (IAB); an easy-to-insert, minimally invasive technology designed to enhance blood flow to the heart and other organs for patients with diminished heart...
Diagnosoft HARP is designed for rapid analysis of tagged cardiac MR images using the HARP technology, which is packaged into an intuitive, easy-to-use graphic user interface....
Medicine Products: