Navigation Links
Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
Date:4/14/2008

SAN DIEGO - A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, researchers at The University of Texas M. D. Anderson Cancer Center report today at the American Association for Cancer Research annual meeting.

An obesity-inducing diet, by contrast, activated those pathways, said first author Tricia Moore, a graduate student in M. D. Anderson's Department of Carcinogenesis.

"These results, while tested in a mouse model of skin cancer, are broadly applicable to epithelial cancers in other tissues," said senior author John DiGiovanni, Ph.D., director of the Department of Carcinogenesis and of M.D. Anderson's Science Park - Research Division in Smithville, Texas.

Epithelial cancers arise in the epithelium - the tissue that lines the surfaces and cavities of the body's organs. They comprise 80 percent of all cancers.

"Calorie restriction and obesity directly affect activation of the cell surface receptors epidermal growth factor (EGFR) and insulin-like growth factor (IGF-1R)," Moore said. "These receptors then affect signaling in downstream molecular pathways such as Akt and mTOR."

"Calorie restriction, which we refer to as negative energy balance, inhibits this signaling, and obesity, or positive energy balance, enhances signaling through these pathways, leading to cell growth, proliferation and survival," Moore said.

Dietary energy balance refers to the relationship between caloric intake and energy expenditure. Previous research, both experimental and epidemiological, suggests that chronic positive energy balance, which can lead to obesity, increases the risk of developing a variety of cancers, DiGiovanni said, while negative balance often decreases risk.

This study employed four diets, two representing calorie reductions of 30 percent and 15 percent, a control diet including 10 percent kilocalories from fat, and an obesity-inducing diet consisting of 60 percent kilocalories from fat . Agents were then given to the mice to induce premalignant lesions called papillomas, which are precursors to cancer.

Those on the calorie restricted diets had statistically significant inhibition of papilloma formation compared with the other two diets.

In a separate experiment the development of carcinomas and the effect of dietary energy balance on conversion of papillomas to carcinomas was evaluated. This study demonstrated that dietary energy balance determines the number of carcinomas found through its effects on the number of premalignant lesions but does not affect the rate of malignant conversion.

Akt and mTOR pathways are known to be important for skin tumor development in this model system. In addition, increased Akt and mTOR signaling are linked to the growth, proliferation and survival of many human cancers.

"These findings provide the basis for future translational studies targeting Akt/mTOR pathways through combinations of lifestyle and pharmacologic approaches to prevent and control obesity-related epithelial cancers in humans," DiGiovanni said.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Calorie restriction limits and obesity fuels development of epithelial cancers
2. New Survey Shows 90 Percent of Women Do Not Fully Understand the Calories They Eat
3. Hostess(R) 100 Calorie Pack Cup Cakes Named A Most Memorable New Product of 2007
4. New Guacamole 100-Calorie Packs - The Solution for Clashing February Holidays
5. Eat This, Not That!(TM): 5 Smart Super Bowl Swaps That Will Save You Hundreds of Calories
6. With Calorie Counting on Holiday Hiatus, NutriSystem Offers Advanced Resolution for 2008
7. Doubled calorie intake from beverages likely contributes to adult obesity
8. Empty-Calorie Diet Tied to Preclinical Heart Disease
9. Calorie-Starved Rats Live Longer: Study
10. Lose Weight, Conquer World Hunger with www.DonateYourCalories.com
11. New Herbal Water Creating Taste Sensation: Ayalas Herbal Water Has No Calories, No Preservatives and No Artificial Additives. Just All the Natural Benefits of Herbs!
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
(Date:3/28/2017)... ... March 28, 2017 , ... ... SkyLex Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon Balloon ... this procedure adds to SkyLex Advanced Surgical’s already comprehensive list of weight-loss ...
(Date:3/28/2017)... ... March 28, 2017 , ... Silicon Valley Hair Institute, the San Francisco Bay ... post about women’s hair loss. Although hair transplant procedures can be seen as more ... or genetics can be two reasons a woman may see her hair thinning. , ...
(Date:3/28/2017)... ... 2017 , ... “A Prophets Bones”: a thrilling adventure that reveals the mystery of Kevin’s purpose. ... that his parents and teachers had asked of him that he had neglected to do, ... defy the Almighty Creator. There were some who would have felt themselves to be special ...
(Date:3/27/2017)... ... March 27, 2017 , ... Drs. ... smile makeovers without requiring a referral. Trimble Dental offers a variety of ... dentistry and dental implants. Whether patients have discolored, crooked or missing teeth in ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... to the OSEHRA popHealth Community in 2014. It is the culmination ... the Developer Open Source Project Group. OSEHRA Organizational Member Zato Health co-funded the ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017 ... attention to these four stocks: The Medicines Co. ... Pharmaceuticals Inc. (NASDAQ: PCRX), and Supernus Pharmaceuticals Inc. ... in the Generic Drugs space which is governed ... The key growth drivers for the industry are wholesalers, ...
(Date:3/28/2017)... 2017 RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced that ... Patent Office (JPO) for the composition of matter ... for the treatment or prevention of fibrotic disorders, ... proliferative retinopathy (Japanese Patent #: 6060071).  This patent ...
(Date:3/27/2017)... SINGAPORE , March 27, 2017 ... a digital health and data analytics company, signed ... collaborations for improving healthcare delivery in the region. ... Institute for Global Health Research and Technology (BIGHEART) ... relationship on several topics related to healthcare IT ...
Breaking Medicine Technology: