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Calorie restriction inhibits, obesity fuels development of epithelial cancers
Date:4/14/2008

cent and 15 percent, a control diet including 10 percent kilocalories from fat, and an obesity-inducing diet consisting of 60 percent kilocalories from fat . Agents were then given to the mice to induce premalignant lesions called papillomas, which are precursors to cancer.

Those on the calorie restricted diets had statistically significant inhibition of papilloma formation compared with the other two diets.

In a separate experiment the development of carcinomas and the effect of dietary energy balance on conversion of papillomas to carcinomas was evaluated. This study demonstrated that dietary energy balance determines the number of carcinomas found through its effects on the number of premalignant lesions but does not affect the rate of malignant conversion.

Akt and mTOR pathways are known to be important for skin tumor development in this model system. In addition, increased Akt and mTOR signaling are linked to the growth, proliferation and survival of many human cancers.

"These findings provide the basis for future translational studies targeting Akt/mTOR pathways through combinations of lifestyle and pharmacologic approaches to prevent and control obesity-related epithelial cancers in humans," DiGiovanni said.


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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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