Navigation Links
Calorie restricted diet prevents pancreatic inflammation and cancer
Date:4/15/2008

SAN DIEGO - Prevention of weight gain with a restricted calorie diet sharply reduced the development of pancreatic lesions that lead to cancer in preclinical research reported today by researchers from The University of Texas at Austin and The University of Texas M. D. Anderson Cancer Center at the American Association for Cancer Research annual meeting.

The research sheds light on the connection between obesity, calorie intake and pancreatic cancer by comparing a calorie restricted diet, an overweight diet and an obesity-inducing diet in a strain of mice that spontaneously develops pancreatic lesions that lead to cancer.

"Obesity is a known risk factor for pancreatic cancer, but the mechanism underlying that relationship is unknown," said senior author Stephen D. Hursting, Ph.D., professor in M. D. Anderson's Department of Carcinogenesis and Chair of the Division of Nutritional Sciences at the University of Texas. "Our findings indicate that calorie restriction hinders development of pancreatic cancer, which could have implications for prevention and treatment of pancreatic tumors caused by chronic inflammation and obesity."

The group's analysis points to a connection between calorie intake and a protein called Insulin-like Growth Factor (IGF) -1, with obesity increasing and calorie restriction decreasing levels of IGF-1. IGF-1 is an important growth factor known to stimulate the growth of many types of cancer cells. Inflammatory signaling proteins also were found to be reduced in the blood of the calorie-restricted mice.

"Mice on the heavier diets had significantly more lesions and larger lesions than those on the restricted calorie diet," said first author Laura Lashinger, Ph.D., a post-doctoral fellow in Hursting's laboratory. The strain of mice, developed by Susan Fischer, professor in M. D. Anderson's Department of Carcinogenesis, spontaneously develops lesions associated with pancreatitis - inflammation of the pancreas. These lesions develop into pancreatic cancer and virtually all of these mice die within six to eight months.

The researchers fed the calorie restricted group a diet that was 30 percent lower in calories than that consumed by the overweight group and 50 percent lower than the obese group. Only 7.5 percent of mice on the calorie-restricted diet developed pancreatic lesions at the end of the experiment, and these lesions were so small that none exhibited symptoms of illness. For mice on the overweight diet, 45 percent developed lesions, as did 57.5 percent of those on the obesity-inducing diet. Lesions were also much larger in the overweight and obese mice than the calorie restricted mice.

While calorie restriction has been shown to have an anti-cancer effect in multiple species and for a variety of tumor types, its impact had not been well-studied in a model of pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer death and remains mostly intractable to existing treatments.

The decline in blood levels of inflammatory proteins in the calorie restricted mice makes sense, Lashinger notes, because fat tissue is a major source of inflammatory factors such as cytokines.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Calorie restriction inhibits, obesity fuels development of epithelial cancers
2. Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can
3. Calorie restriction limits and obesity fuels development of epithelial cancers
4. New Survey Shows 90 Percent of Women Do Not Fully Understand the Calories They Eat
5. Hostess(R) 100 Calorie Pack Cup Cakes Named A Most Memorable New Product of 2007
6. New Guacamole 100-Calorie Packs - The Solution for Clashing February Holidays
7. Eat This, Not That!(TM): 5 Smart Super Bowl Swaps That Will Save You Hundreds of Calories
8. With Calorie Counting on Holiday Hiatus, NutriSystem Offers Advanced Resolution for 2008
9. Doubled calorie intake from beverages likely contributes to adult obesity
10. Empty-Calorie Diet Tied to Preclinical Heart Disease
11. Calorie-Starved Rats Live Longer: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Calorie restricted diet prevents pancreatic inflammation and cancer
(Date:5/3/2016)... ... May 03, 2016 , ... Elizabeth Murray has always loved walking one ... with one on her shoulder and one on her arm. But she got to ... years of mitral valve prolapse. , The valves of the heart wouldn’t close properly ...
(Date:5/3/2016)... Pasadena, CA (PRWEB) , ... May 03, 2016 ... ... tuition-free, accredited American online university, has announced today the launch of its Associates ... Nobel Laureate and President Emeritus of The Rockefeller University, Dr. Torsten N. Wiesel; ...
(Date:5/3/2016)... , ... May 03, 2016 , ... Boston Children’s Hospital ... rehearse tough medical situations or practice tricky or rare procedures in an environment that ... the SIM Center is also available to inventors and “hackers” to develop and test ...
(Date:5/3/2016)... ... 03, 2016 , ... Park Cities Pet Sitter has openings for both full-time ... 75205, 75206, 75209, 75219, 75220, 75225, 75229, 75230, 75231 and 75235 zip codes. ... Plano, Preston Hollow and Park Cities areas of the Metroplex. Candidates must love ...
(Date:5/3/2016)... York, NY (PRWEB) , ... May 03, 2016 ... ... solutions for the healthcare industry, announced today that Legacy Health is expanding its ... Efficient Works platform), after a highly successful initial proof of concept. The Portland, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016  As a teenager, an active and ... which damaged his heart. He continued enjoying sports and ... 2013, Shepherd,s heart was giving out and he was ... 20, 2013, the Mesa, Arizona ... Like a heart transplant, the SynCardia TAH-t is the ...
(Date:5/3/2016)... 3, 2016   BIOTRONIK , a leader ... Food and Drug Administration (FDA) approval of Iperia ... heart failure patients with access to diagnostic magnetic ... remote monitoring with daily automatic transmission and closed ... in response to physiological demands. ...
(Date:5/3/2016)... LAKE OSWEGO, Ore. , May 3, 2016 /PRNewswire/ ... about the importance of extending care beyond the implant ... Scientific Sessions, May 4-7 in San Francisco ... tasked with continually delivering the highest quality of patient ... ensuring patients are cared for each and every tomorrow," ...
Breaking Medicine Technology: