Navigation Links
Calorie-burning brown fat is a potential obesity treatment, researchers say

A new study suggests that many adults have large amounts of brown fat, the "good" fat that burns calories to keep us warm, and that it may be possible to make even more of this tissue.

The study's lead author, Aaron Cypess, MD, PhD, will present the results Sunday at The Endocrine Society's 93rd Annual Meeting in Boston.

"We are now even more optimistic that brown fat could be used for treating obesity and diabetes," said Cypess, an assistant professor at Harvard Medical School and the Joslin Diabetes Center in Boston.

Cypess heads the research team that two years ago published a study showing that brown fat is present in adults, not just in infants and small mammals, as scientists had thought. Although most adult fat is calorie-storing white fat, most adults have some brown fat in an area extending from the front of the neck to the chest, he reported at The Endocrine Society's meeting in 2009.

Now they have learned that brown fat cells lie in deeper fat, not superficial fat, and that the number of regions of brown fat varies by person, Cypess reported. They discovered this by measuring the expression of a protein found exclusively in brown fat, called uncoupling protein-1. However, even in those regions where many brown fat cells are present, they are mixed with white fat cells.

"It's a marbling at the cellular level," Cypess said. "We wondered: Wouldn't it be nice if you could grow more brown fat? The answer is yes."

In their new study, the researchers succeeded in growing mature human brown fat cells from preadipocytes, or pre-fat cells, that they obtained from a fresh sample of brown fat taken from the neck of a patient having routine surgery. The process took about two weeks in a laboratory dish but likely occurs more quickly in the body, Cypess said.

"Some of these preadipocytes may have the choice to become either white or brown fat," he said.

In another experiment, Cypess and his colleagues measured how many calories brown fat burns. To do so, they measured the fat cells' oxygen consumption rate in both cultures and surgical tissue samples from volunteers.

"We demonstrated that brown fat burns up a substantial number of calories," Cypess said. "We have an organ in our body whose job it is to generate heat and burn calories."

Although Cypess said stimulating the growth of additional brown fat may be a promising treatment of obesity, it cannot replace traditional approaches such as diet and exercise. He said, "As powerful as brown fat could be at burning calories, we can easily out-eat the benefit."


Contact: Aaron Lohr
The Endocrine Society

Related medicine news :

1. Brown Fat Cells May One Day Help Combat Obesity
2. Nobel laureates Brown, Goldstein to give inaugural Stadtman award lecture
3. Univ. of Kentucky Sanders-Brown Center on Aging awarded Alzheimers drug discovery research grant
4. Researchers Turn White Fat to Energy-Burning Brown Fat in Mice
5. Brown Rice Bests White for Diabetes Prevention
6. God is a Brown Girl Too Awakens Women to Love at its July Retreat in New York
7. Brown Rice Tied to Better Heart Health in Study
8. Cause and potential treatment found for cancer drugs kidney toxicity
9. Potential new drug candidate found for Alzheimers disease
10. The Potential to Modify the Course of Parkinsons Disease
11. Potentially Toxic Flame Retardants Found in Baby Products
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Dr. Poneh Ghasri, dentist in West Hollywood ... 2015. The research, which was conducted at the Dental Institute at King's College London ... between stress during pregnancy and future dental health in the child. For years, researchers ...
(Date:10/13/2015)... ... October 13, 2015 , ... Protein is essential to good health. ... bone, and blood. But how much protein does the average man need in order ... according to the October 2015 issue of Harvard Men's Health Watch . Most ...
(Date:10/13/2015)... Waycross, GA (PRWEB) , ... October 13, 2015 ... ... charitable nonprofit promoting the establishment of telemedicine programs in communities throughout Georgia, along ... (FTP) announce the collective schedule for their regional telehealth summits for Fall 2015. ...
(Date:10/13/2015)... ... 13, 2015 , ... According to an ESPN report published on ... teammate accidentally elbowed him in the left eye during the first day of practice ... of a series of setbacks, including a knee injury that has interfered with his ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an ongoing effort ... , a Southlake, Texas, child development and pediatric therapy center, is working with ... families about their options for receiving this kind of care for affected children. ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Fla. , Oct. 13, 2015   Vigilant ... of solutions that aid in the early detection and ... has awarded Vigilant,s founder and CEO, Matthew H.J. ... Year Award, which recognizes an entrepreneur who has made ... life sciences industry in the leadership of ...
(Date:10/13/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... serving the pharmaceutical, biotechnology, and medical device industries, ... version of OncoWuXi, the first App in the ... and data on the go.  The OncoWuXi App ... to identify relevant tumor models for use in ...
(Date:10/13/2015)... 13, 2015   Happy Vitals ®, ... home testing kit for breast milk.  The ... an unparalleled, detailed assessment of the nutrition ... carbs and key vitamins—all charted over time ... health tracking.  In addition, Happy Vitals also offers ...
Breaking Medicine Technology: