Navigation Links
Caloric restriction has a protective effect on chromosomes
Date:1/23/2013

One of the indicators of a cell's health is the state of its DNA and containersthe chromosomesso when these fuse together or suffer anomalies, they can become the source of illnesses like cancer and/or ageing processes.

According to a study carried out by a team led by Mara Blasco, the director of the Spanish National Cancer Research Centre (CNIO) and head of the Telomeres and Telomerase Group, a sustained lowering of food intake over time results in an increase of telomere lengththe ends of chromosomesin adult mice, which has a protective effect on the DNA and genetic material.

These beneficial effects on the youth of the chromosomes translate to a lower incidence of cancer and other age-related illnesses. The journal PLOS ONE is to publish the details of this study in its online edition this week.

A lower incidence of cancer and better health

To carry out the study, researchers used young micejust three months oldand reduced their caloric intake by 40% before observing them until the end of their life cycle.

"We see that mice that undergo caloric restriction show a lower telomere shortening rate than those fed with a normal diet," says Blasco. "These mice therefore have longer telomeres as adults, as well as lower rates of chromosome anomalies," she adds.

To study the effects of this phenomenon on the health of the mammals, researchers observed the incidence of age-related illnesses like cancer. The mice that had been fed a lower calorie intake showed a reduction in the incidence of cancer. Furthermore, these mice also showed a lower incidence of other age-related illnesses such as osteoporosis, greater glucose uptake or improvements in motor coordination.

When the researchers carried out these same experiments with a variety of mice that produce more telomerasea protein that lengthens telomeres and protects chromosomesthey observed that these mice not only enjoyed better health but also lived up to 20% longer.

"We believe that such a significant increase in longevity is due to the protective effect against cancer produced by caloric restrictionincidences fall by 40% if we compare them with the mice that produce more telomerase and have a normal dietand, added to the presence of longer telomeres, this makes the mice live longer and better," says Blasco.

Despite the effects of caloric restriction depending on the genetic characteristics of each organism, this study opens the way to studying the effect other factors and lifestyle habits, such as smoking or exercise, might have on ageing.

Furthermore, it is calculated that there are currently more than 10,000 people in the world on some form of controlled caloric restriction, so the observation of these individuals will be decisive in discovering the effects of this type of diet on humans.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Are restrictions to scientific research costing lives?
2. Time restrictions on TV advertisements ineffective in reducing youth exposure to alcohol ads
3. Many Americans Back Nicotine Restrictions in Cigarettes: Survey
4. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
5. Study identifies possible protective blood factors against Type 2 diabetes
6. NIH team describes protective role of skin microbiota
7. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
8. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
9. National study shows protective eyewear reduces eye, head, and facial injuries
10. Alcohol provides protective effect, reduces mortality substantial
11. Protective communities may reduce risk of drinking in teens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
(Date:10/12/2017)... ... , ... In the United States, single-family home owners pay ... York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is $7,000 a ... rates, which contributes to the relatively lower cost of living in places like ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the University of California Berkeley, and other leading institutions in announcing the launch ... of institutions to change the way animals are raised for food. , Founding ...
(Date:10/12/2017)... San Antonio, Texas (PRWEB) , ... October 12, ... ... medical device and biologics manufacturer, has expanded its executive staff with the addition ... Development. , In this role, Slott will develop the national distribution and sales ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading ... announced that its MyDario product is expected to appear on The Dr. ... The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show ... The segment ...
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
Breaking Medicine Technology: