Navigation Links
Calcium plus vitamin D supplementation is not associated with a reduced breast cancer risk
Date:11/11/2008

Taking calcium and vitamin D supplements does not reduce breast cancer incidence in postmenopausal women, according to data from a randomized, doubled-blind, placebo-controlled trial published online November 11 in the Journal of the National Cancer Institute.

Several observational and preclinical studies have suggested that vitamin D supplements may reduce breast cancer risk, but results have been inconsistent.

To test this possibility, researchers evaluated breast cancer incidence as a secondary endpoint in the Women's Health Initiative study in 36,282 postmenopausal women who were randomly assigned to take 1,000 mg of calcium plus 400 IU of vitamin D daily or to daily placebo. (The primary endpoint of the study was effect of the supplements on hip fracture.) Baseline 25-hydroxyvitamin D levels were determined in all 1,067 breast cancer cases and 1,067 matched control subjects.

In the current analysis, Rowan Chlebowski, M.D., Ph.D., of the Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center and colleagues found that the incidence of invasive breast cancer was similar in the supplement and placebo groups, with 528 and 546 cases, respectively. Additionally, 25-hydroxyvitamin D levels were only modestly associated with dietary and supplement vitamin D intake and were not associated with breast cancer risk in a nested case-control analysis.

These findings call into question recommendations for evaluation of higher vitamin D dosage in future studies, according to the authors. Furthermore, as 25-hydroxyvitamin D levels were strongly associated with leanness and high physical activity, which both influence breast cancer risk, prior observational studies relating vitamin D levels to breast cancer risk may have been influenced by these factors. "The main findings do not support a causal relationship between calcium and vitamin D supplement use and reduced breast cancer incidence" the authors conclude.

In an accompanying editorial, Corey Speers and Powel Brown, M.D., Ph.D., of Baylor College of Medicine in Houston applaud the authors' efforts to test the question in such a rigorous manner. Although the editorialists agree that these data do not support an association between calcium and vitamin D supplementation and breast cancer incidence, they argue that further investigation is still needed to adequately answer the question, including looking for genetic influences on vitamin D serum levels, testing supplements in premenopausal women, and following study participants for a longer follow-up period.

"Because preclinical, epidemiological, and clinical trial results of vitamin D supplementation are conflicting, additional studies will be needed to determine whether vitamin D plus calcium will prevent breast cancer. However, this article by Chlebowski [and colleagues] offers an important first step in addressing this issue," the editorialists write. "The potential health benefits of vitamin D and calcium may yet still have a bright future."


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Daily Calcium Does Protect Bone
2. International study strengthens case for daily calcium pill
3. Coronary Artery Calcium May Raise Womens Heart Risk
4. Calcium Supplements Could Raise Heart Risks in Postmenopausal Women
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. High Calcium Intake May Not Help Prevent Fractures, Reports The Harvard Health Letter
7. Calcium Scans Help Predict Coronary Risk
8. African Americans at Risk for Low Calcium Intake - New Survey Finds Those Experiencing Symptoms of Lactose Intolerance May be Sidelining Dairy in Their Diets
9. Study shows that administering calcium and magnesium effectively reduces neurological sensitivity
10. Coronary calcium distribution tied to heart attack risk
11. New Calcium Measure Better Predictor of Heart Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... 20, 2017 , ... Announced that Clear Global ... services market) has entered into an agreement on September 1, 2017 with The ... is the first private Dental School to launch an online, accredited Post Graduate ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... gather for the National Athletic Trainers’ Association Annual Clinical Symposium and Expo. New ... It is also when Athletic Trainers are acknowledged by their peers with accolades ...
(Date:9/20/2017)... ... 2017 , ... Five consumer packaged goods (CPG) products were selected by the ... Nopavera Plus was named to the short list in the Specialty Supplements ... during presentations at SupplySide Central on Sept. 27 and 28 at Mandalay Bay Resort ...
(Date:9/20/2017)... Eugene, OR (PRWEB) , ... September 20, 2017 , ... ... OSHA 10- and 30-Hour and HAZWOPER 8-, 24- and 40-Hour courses from now until ... , In addition to offering these discounted prices to all businesses and government ...
(Date:9/20/2017)... ... ... “RECYCLED Ezekiel's Plan for Freedom from ADDICTION”: A Bible-inspired ... the creation of published author, Bill Miller. Bill Miller has a unique ... than a decade of addiction to prescription drugs. He has a Bachelor ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... N.Y. , Sept. 6, 2017   PDI , ... announced it will host an educational session focused on ... bloodstream infection (CLABSI) prevention at the 2017 Annual Scientific ... which will take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s ...
(Date:9/5/2017)... N.J. , Sept. 5, 2017  Getinge, ... has created a vibrant charitable donation program -- ... and support congenital heart defect research by The ... providers and the general public are encouraged to ... and submit the completed artwork to the gallery ...
(Date:9/1/2017)... 1, 2017  Bayer will present the latest research from ... Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... preclinical and clinical data on Bayer,s marketed portfolio and late-stage ... "We value the ... cancer research at ESMO," said Carsten Brunn , Head ...
Breaking Medicine Technology: