Navigation Links
Calcium may be the key to understanding Alzheimer's disease
Date:7/18/2008

PHILADELPHIA, PA - Researchers at the University of Pennsylvania School of Medicine have shown that mutations in two proteins associated with familial Alzheimer's disease disrupt the flow of calcium ions within neurons. The two proteins, called PS1 and PS2 (presenilin 1 and 2), interact with a calcium release channel in an intracellular cell compartment.

"The 'calcium dysregulation' hypothesis for inherited, early onset familial Alzheimer's disease has been suggested by previous research findings, but our current study identifies a molecular mechanism that makes this hypothesis very compelling," says lead author J. Kevin Foskett, PhD, Professor of Physiology. "Mutated PS1 and PS2 caused exaggerated cellular calcium signaling in cells through a calcium channel in the endoplasmic reticulum called the inositol trisphosphate receptor [InsP3R], suggesting that it or other proteins in this calcium signaling pathway could be targets for new Alzheimer's disease therapies." The study appeared in the June 26 issue of Neuron.

Alzheimer's disease affects as many as 5 million Americans, 5 percent of whom have the familial form. The hallmark of the disease is the accumulation of tangles and plaques of amyloid beta protein in the brain. "The amyloid hypothesis has long been invoked to explain the cause of Alzheimer's" says Foskett. In the Neuron study, cells that carried the disease-causing mutated form of PS1 showed increased processing of amyloid beta that depended on the interaction of the PS proteins with the InsP3R. This observation links mis-regulation of calcium inside cells with the production of amyloid, a characteristic feature in the brains of people with Alzheimer's disease.

Current therapies for Alzheimer's include drugs that treat the symptoms of cognitive loss and dementia. Drugs that address the pathology of Alzheimer's are only experimental. For example, a vaccine that stimulates antibodies to amyloid beta is currently being
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study finds coronary arterial calcium scans help detect overall death risk in the elderly
2. Arterial Calcium Scans Can Predict Death Risk
3. New Calcium Measure Better Predictor of Heart Risks
4. Coronary calcium distribution tied to heart attack risk
5. Study shows that administering calcium and magnesium effectively reduces neurological sensitivity
6. African Americans at Risk for Low Calcium Intake - New Survey Finds Those Experiencing Symptoms of Lactose Intolerance May be Sidelining Dairy in Their Diets
7. Calcium Scans Help Predict Coronary Risk
8. High Calcium Intake May Not Help Prevent Fractures, Reports The Harvard Health Letter
9. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
10. Calcium Supplements Could Raise Heart Risks in Postmenopausal Women
11. Coronary Artery Calcium May Raise Womens Heart Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... injection drug users in Russia might contribute to ... study, conducted by researchers from Boston University Schools ... St. Petersburg Pavlov State University, sought to discover ... outcomes of a cohort of HIV-positive people with ... were arrested by police were more likely to ...
(Date:7/9/2014)... been a sharp increase in the number of cancer ... online, interactive service that allows patients to view laboratory ... appointments, and renew prescriptions. , Over a six-year period, ... each year increased five-fold, while the number of total ... a study by Dr. David Gerber , Associate ...
(Date:7/9/2014)... may smell of flatulence and have a reputation for being ... hydrogen sulfide is now being being found to offer potential ... stroke, heart attacks and dementia. A new compound (AP39), designed ... key to future therapies, by targeting delivery of very small ... inside cells. , Scientists in Exeter have already found ...
(Date:7/9/2014)... and poor printing on prescription labels handed out ... to errors in taking medication, according to new ... (Canadian National Institute for the Blind)., The study, ... , found that labels on prescription medications dispensed ... guidelines for legibility. , By simply following recommended ...
(Date:7/9/2014)... in Western societies. One frequently cited reason is that ... infections than previous generations, thereby delaying maturation of the ... Academy, University of Gothenburg, monitored children until the age ... in relation to allergic disease. All of the children ... half of them on farms that produced milk.,Lower risk ...
Breaking Medicine News(10 mins):Health News:BU researchers relate arrests with HIV risk environment 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Rotten egg gas holds key to healthcare therapies 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... impact film scenes have on their kids, , , TUESDAY, March ... drinking alcohol should be factored into movie ratings, fewer than ... rating for a film. , And, only about one-quarter ... on its own to justify an R rating. Yet, ...
... analyst for Lincoln Park Zoo,s Urban Wildlife Institute was ... worldwide to receive the prestigious Smith Fellowship from the ... It is recognized as the nation,s premier post doctoral ... is aimed at finding solutions to the most urgent ...
... WESTLAKE VILLAGE, Calif., March 3 /PRNewswire/ ... announced today that it is expanding the states ... SOC is the country,s largest private provider of ... managed more than 5,500 emergency neurology consultations to ...
... partnership with the Forum, Unveil Disease "Hot Spots" - ... - an alliance of patient advocates, dialysis ... quality of care for individuals with kidney disease and ... the racial disparity among those suffering from Chronic Kidney ...
... America, Inc., a leading medical diagnostic instrument manufacturer ... of the Sysmex WAM eLearning program to its ... the U.S. Sysmex WAM eLearning gives customers a ... WAM users and as a tool to assist ...
... entitled Motorcycle Cancer? is sending a ... seat extremely low frequency electromagnetic field (ELF EMF) ... Randall Dale Chipkar. "Science proves electromagnetic danger and ... read up to 500 milliGauss of ELF EMF ...
Cached Medicine News:Health News:Smoking, Drinking Should Matter in Movie Ratings, Parent Survey Finds 2Health News:Smoking, Drinking Should Matter in Movie Ratings, Parent Survey Finds 3Health News:Lincoln Park Zoo researcher awarded prestigious conservation biology fellowship 2Health News:Specialists On Call Expands Access to Emergency Neurology On-Call Services in Montana 2Health News:Kidney Care Partners Raises Alarm on Racial Disparities in Kidney Disease; Joins With National Minority Quality Forum to Educate Public, Congress During National Kidney Month 2Health News:Kidney Care Partners Raises Alarm on Racial Disparities in Kidney Disease; Joins With National Minority Quality Forum to Educate Public, Congress During National Kidney Month 3Health News:Sysmex America Introduces On Demand Middleware Training Tool 2Health News:Motorcycle Cancer Risk: Motorcycle Cop Cancer Concern from ELF EMFs Penetrating Motorcycle Seats 2
(Date:1/15/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ... by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), ... of Solta Medical, Inc. (NASDAQ: SLTM ) ...
(Date:1/14/2014)... , Jan. 14, 2014 HeartWare International, Inc ... of less invasive, miniaturized circulatory support technologies that are ... that it expects revenues for the fourth quarter of ... 2013 revenues to approximately $208 million. "Our ...
(Date:1/14/2014)... Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw ... with accompanying instrumentation to place and insert the screw ... soft tissue (e.g. ligament) repair or reconstruction as it ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... 2009 Convention -- When Shawnae Jebbia won the Miss USA ... career. She appeared at events throughout the world, worked as ... world unexpectedly changed when she was diagnosed with hearing loss. ... had a difficult time understanding and accepting the sudden hearing ...
... eResearchTechnology, Inc. (ERT), (Nasdaq: ERES ), a leading provider ... medical device and related industries, announced today results for the ... Unless otherwise noted, all comparative numbers refer to changes from ... , Financial highlights for the third quarter of 2009: ...
Cached Medicine Technology:Former Miss USA Shawnae Jebbia Shines with Siemens Pure 2Former Miss USA Shawnae Jebbia Shines with Siemens Pure 3ERT Reports Third Quarter 2009 Results 2ERT Reports Third Quarter 2009 Results 3ERT Reports Third Quarter 2009 Results 4ERT Reports Third Quarter 2009 Results 5ERT Reports Third Quarter 2009 Results 6ERT Reports Third Quarter 2009 Results 7ERT Reports Third Quarter 2009 Results 8ERT Reports Third Quarter 2009 Results 9ERT Reports Third Quarter 2009 Results 10ERT Reports Third Quarter 2009 Results 11ERT Reports Third Quarter 2009 Results 12ERT Reports Third Quarter 2009 Results 13
8 X 1 Red Filter. Color Filters are designed to filter out all other color regions of the visible spectrum except the specified color. Color Filters are excellent for contrast enhancement and color r...
Features a twist-on backswitch, with a diffused, cobalt blue light beam....
Heavy duty, all purpose illuminator available in black only. Unique Clip Switch automatically turns off when returned to pocket. Pre-focused lens tip Heine XHL Halogen bulb for bright, concentrated l...
... A child-friendly vision ... and takes just seconds. ... the first objective, accurate ... reliable early detection of ...
Medicine Products: