Navigation Links
Calcium may be the key to understanding Alzheimer's disease
Date:7/18/2008

PHILADELPHIA, PA - Researchers at the University of Pennsylvania School of Medicine have shown that mutations in two proteins associated with familial Alzheimer's disease disrupt the flow of calcium ions within neurons. The two proteins, called PS1 and PS2 (presenilin 1 and 2), interact with a calcium release channel in an intracellular cell compartment.

"The 'calcium dysregulation' hypothesis for inherited, early onset familial Alzheimer's disease has been suggested by previous research findings, but our current study identifies a molecular mechanism that makes this hypothesis very compelling," says lead author J. Kevin Foskett, PhD, Professor of Physiology. "Mutated PS1 and PS2 caused exaggerated cellular calcium signaling in cells through a calcium channel in the endoplasmic reticulum called the inositol trisphosphate receptor [InsP3R], suggesting that it or other proteins in this calcium signaling pathway could be targets for new Alzheimer's disease therapies." The study appeared in the June 26 issue of Neuron.

Alzheimer's disease affects as many as 5 million Americans, 5 percent of whom have the familial form. The hallmark of the disease is the accumulation of tangles and plaques of amyloid beta protein in the brain. "The amyloid hypothesis has long been invoked to explain the cause of Alzheimer's" says Foskett. In the Neuron study, cells that carried the disease-causing mutated form of PS1 showed increased processing of amyloid beta that depended on the interaction of the PS proteins with the InsP3R. This observation links mis-regulation of calcium inside cells with the production of amyloid, a characteristic feature in the brains of people with Alzheimer's disease.

Current therapies for Alzheimer's include drugs that treat the symptoms of cognitive loss and dementia. Drugs that address the pathology of Alzheimer's are only experimental. For example, a vaccine that stimulates antibodies to amyloid beta is currently being
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study finds coronary arterial calcium scans help detect overall death risk in the elderly
2. Arterial Calcium Scans Can Predict Death Risk
3. New Calcium Measure Better Predictor of Heart Risks
4. Coronary calcium distribution tied to heart attack risk
5. Study shows that administering calcium and magnesium effectively reduces neurological sensitivity
6. African Americans at Risk for Low Calcium Intake - New Survey Finds Those Experiencing Symptoms of Lactose Intolerance May be Sidelining Dairy in Their Diets
7. Calcium Scans Help Predict Coronary Risk
8. High Calcium Intake May Not Help Prevent Fractures, Reports The Harvard Health Letter
9. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
10. Calcium Supplements Could Raise Heart Risks in Postmenopausal Women
11. Coronary Artery Calcium May Raise Womens Heart Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... September 18, 2014 Companies in the ... carbon dioxide, selling it to downstream industries in either ... carbon dioxide are food and beverage manufacturers. Food producers ... fruits, vegetables or pizzas. The gas is also used ... the compound to carbonate soft drinks, beer and other ...
(Date:9/18/2014)... supplements of selenium or vitamin E don,t seem ... men, a new study indicates. Previous animal research ... cataracts. To investigate this further, William Christen, from Brigham ... and his colleagues examined data from a randomized, placebo-controlled ... initially designed to study prevention of prostate cancer. ...
(Date:9/18/2014)... TayganPoint Consulting Group, a leading ... and co-founder John Cassimatis was named as one ... 2014, recognizing the region’s top healthcare and life ... of the year. , The Innovation Awards celebrate ... continue to shape the medical industry in Greater ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Stealth ... and wellness advocate, and Frank Davis, founder of ... Whole-food Nutrition, are pleased to announce the new ... to make delicious, nutrition-packed meals using Activz whole-food ... the next step in the Stealth Health ...
(Date:9/18/2014)... expect to pay higher employee contributions for their health ... officers about the impact of the Patient Protection and ... conducted by the Darla Moore School of Business at ... Patrick Wright, a professor in strategic human resource management, ... Officers. The survey is distributed to more than 560 ...
Breaking Medicine News(10 mins):Health News:Carbon Dioxide Production in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Carbon Dioxide Production in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Vitamin E, Selenium Supplements Don't Seem to Prevent Cataracts 2Health News:TayganPoint Executive Receives Prestigious Award from Philadelphia Business Journal 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 3Health News:Survey: Fortune 500 employees can expect to pay more for health insurance 2Health News:Survey: Fortune 500 employees can expect to pay more for health insurance 3
... director of chemical and food safety programs with Pew Health ... response to the introduction of the Food Safety Modernization Act ... , "In the midst of an ongoing peanut product recall, ... not be more timely. The FSMA contains key improvements that ...
... The Greater Baltimore Committee is seeking nominations for ... Thursday, March 12, 2009. Those interested in nominating a ... . The four award categories are: Entrepreneurial, Best New ... Nominators will be asked to submit documentation and narratives ...
... Feb. 4 Speaker Nancy Pelosi and parents and children ... a photo opportunity this morning before the final House vote ... this afternoon. Below are the Speaker,s remarks and answer to ... in the House of Representatives and in the Congress of ...
... architect of BurrellesLuce 2.0, will be the featured speaker at the ... of America. , ... Livingston, NJ (PRWEB) February 4, 2009 -- Jeffrey ... , will be the featured speaker at the Feb. 11th luncheon ...
... Compuware Corporation (Nasdaq:, CPWR ) today announced ... Health,Initiative with a collaborative network for the secure ... The VIP Health,Initiative was formed by Scripps Mercy ... to enhance the quality of care,delivered while also ...
... Saturday, February 7 -- 8 a.m. - 3 p.m.DETROIT, Feb. ... more to smile about.With the help of dentists, dental hygienists, ... School of Dentistry will provide free oral health care ... Saturday, Feb. 7 from 8 a.m. to 3 p.m. on ...
Cached Medicine News:Health News:Statement From Pew Health & Human Services Policy Program on the Introduction of the Delauro Food Safety Modernization Act 2Health News:GBC Seeks Nominations for Fourth Annual Bioscience Awards 2Health News:Pelosi: 'Today is a Very Special Day for Us in the House; We Are Going to Help 11 Million Children' 2Health News:BurrellesLuce IT Expert to Explore Web 3.0's Potential PR Impact At February Luncheon Meeting of Westchester/Fairfield PRSA 2Health News:BurrellesLuce IT Expert to Explore Web 3.0's Potential PR Impact At February Luncheon Meeting of Westchester/Fairfield PRSA 3Health News:Compuware Covisint to Network VIP Health Initiative and Its Physicians, Enabling Improved Collaboration, Better Care 2Health News:Compuware Covisint to Network VIP Health Initiative and Its Physicians, Enabling Improved Collaboration, Better Care 3Health News:UDM School of Dentistry 'Gives Kids A Smile' 2
(Date:9/18/2014)...   3D Systems   (NYSE: DDD ) ... , a new robotic surgery skills and procedural training simulator, ... ERUS exhibition in Amsterdam, The Netherlands ... minimally invasive surgery represents a growing portion of overall surgical ... for robotic surgery has increased, and it is expected that ...
(Date:9/18/2014)...  Neurotrope, Inc. (OTCQB: NTRP) today announced the appointment ... the Company,s Board of Directors, effective September 12, 2014. ... the Board of seven members. Dr. Altstiel will also ... and a member of the Audit and Compensation Committees ... Scientific Advisory Board, a position he has held since ...
(Date:9/18/2014)... , Sept. 18, 2014 Australian biomarker discovery ... US trial of its MiStat™ prostate cancer screening test, ... regulatory approval upon completion. Minomic,s proprietary MiStat™ ... presence of a proprietary biomarker known as the MIL-38 ... prostate cancer cells. Researchers at 11 ...
Breaking Medicine Technology:3D Systems Introduces New Simbionix Robotics Training Platform 23D Systems Introduces New Simbionix Robotics Training Platform 3Larry D. Altstiel, M.D., Ph.D. Joins Neurotrope Board of Directors 2Larry D. Altstiel, M.D., Ph.D. Joins Neurotrope Board of Directors 3Larry D. Altstiel, M.D., Ph.D. Joins Neurotrope Board of Directors 4Minomic Launches US Pilot Study of MiStat(TM) Novel Prostate Cancer Screening Technology 2
... EATONTOWN, N.J. , Jan. 14 Osteotech, Inc. (Nasdaq: ... products for regenerative healing, today reported preliminary unaudited revenue for the ... $24.6 million for the same period in 2008.  During ... revenue from sales of its new innovative products all currently in ...
... and NORTH BRUNSWICK, N.J. , Jan. 14 ... that they have achieved the initial milestone of a research ... vitro test for potential allergic reactions to substances that could ... "Allergy Test on a Chip™," is intended to comprise a ...
Cached Medicine Technology:Osteotech Announces Preliminary Fourth Quarter 2009 Revenue 2Osteotech Announces Preliminary Fourth Quarter 2009 Revenue 3Osteotech Announces Preliminary Fourth Quarter 2009 Revenue 4L'OREAL and Hurel Corporation Announce R&D Collaboration to Develop a Non-Animal Alternative, Microfluidic Biochip 2L'OREAL and Hurel Corporation Announce R&D Collaboration to Develop a Non-Animal Alternative, Microfluidic Biochip 3
Used to negotiate tortuous vessels....
BiodivYsio stent with biocompatible coating (phosphorylcholine)...
... The CYPHER Sirolimus-eluting Coronary Stent ... drug, called "sirolimus", a controlled-release ... delivery platform. Upon placement, sirolimus ... and impedes the process of ...
PT wires combine the enhanced durability of a linear elastic nitinol distal core and a highly resilient polymer tip. This provides excellent access in difficult cases involving severe tortuosity, tig...
Medicine Products: