Navigation Links
Calcium in early life may prevent obesity later
Date:5/13/2010

There's no denying that people need calcium for strong, healthy bones. But new research from North Carolina State University suggests that not getting enough calcium in the earliest days of life could have a more profound, lifelong impact on bone health and perhaps even obesity than previously thought.

During an 18-day trial involving 24 newborn pigs, the researchers documented markedly lower levels of bone density and strength in 12 piglets fed a calcium-deficient diet compared to 12 piglets that received more calcium. Not only that, but when researchers looked at certain stem cells in bone marrow, they found that many of these cells in the calcium-deficient piglets appeared to have already been programmed to become fat cells instead of bone-forming cells.

Because these programmed mesenchymal stem cells replicate to provide all the bone-forming cells for an animal's entire life, very early calcium deficiency may have predisposed the piglets to have bones that contain more fat and less mineral. That could make those pigs more prone to osteoporosis and obesity in later life, said Dr. Chad Stahl, an associate professor of animal science who led the study.

In a longer-term study that Stahl plans to begin this month, the researchers will look at whether that's the case: By conducting a longer feeding trial, the scientists will be able to see if the changes persist through sexual maturity, which occurs for pigs at around eight months of age.

The researchers are using pigs as a model for human health because pigs and humans are similar when it comes to bone growth and nutrition. Pigs are one of the few animals known to experience bone breaks related to osteoporosis, Stahl said.

One of the most surprising findings of the 18-day feeding study was that while the calcium-deficient pigs had substantially lower bone strength and density, blood tests didn't indicate any difference in levels of the hormonal form of vitamin D, which regulates the amount of calcium circulating in the blood of older children and adults. Stahl said this suggests that calcium regulation in newborns isn't dependent on vitamin D.

Stahl thinks the research is relevant to the infant food industry and suggests the significance of the nutritional status of breastfeeding mothers. It also points to a need for greater emphasis in very early life on bone health, not just during those times when children are growing most rapidly.

"While the importance of calcium nutrition throughout childhood and adolescence is well-recognized, our work suggests that calcium nutrition of the neonate may be of greater importance to lifelong bone health, due to its programming effects on mesenchymal stem cells," Stahl reported at the recent Experimental Biology 2010 meeting in Anaheim. "It also points to a potential paradigm shift in which health professionals might want to begin thinking about osteoporosis not so much as a disease of the elderly, but instead as a pediatric disease with later onset.

"For me," Stahl said, "the biggest message is that calcium nutrition, or mineral nutrition as a whole, needs to be a priority from day one. Early life nutrition is setting children up physiologically for the rest of their lives."


'/>"/>

Contact: Dr. Chad Stahl
chad_stahl@ncsu.edu
919-513-1512
North Carolina State University
Source:Eurekalert

Related medicine news :

1. Calcium Scan Improves Heart Risk Prediction
2. SumNuts Vitamin Nuts Launched, Enhanced with Vitamin D3 and Calcium
3. Report: AdvaCALCalcium Builds Bone Best
4. AlgaeCal Inc is Pleased to Announce The First Ever Certified Organic Calcium: Algas Calcareas
5. Vitamin D Plus Calcium Guards Against Fractures
6. A role for calcium in taste perception
7. Infectious diseases caused two-thirds of the nearly 9 million child deaths globally in 2008
8. JCI online early table of contents: May 17, 2010
9. Medical costs of cancer have nearly doubled over the past 2 decades
10. Whole body MRI is highly accurate in the early detection of breast cancer metastases
11. Effects of TV, Drug Exposures in Early Life May Be Long-Lasting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
Breaking Medicine Technology: