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Caffeine's effect on the brain's adenosine receptors visualized for the first time
Date:11/1/2012

of cerebral A1 adenosine receptors will result in adaptive changes and lead to chronic alterations of receptor express and availability.

"There is substantial evidence that caffeine is protective against neurodegenerative diseases like Parkinson's or Alzheimer's disease," noted Elmenhorst. "Several investigations show that moderate coffee consumption of 3 to 5 cups per day at mid-life is linked to a reduced risk of dementia in late life. The present study provides evidence that typical caffeine doses result in a high A1 adenosine receptor occupancy and supports the view that the A1 adenosine receptor deserves broader attention in the context of neurodegenerative disorders."

Caffeine is the most commonly consumed psychoactive substance worldwide and an active ingredient in innumerable food and beverages. Eighty percent of U.S. adults consume caffeine every day; the average for adults is 200 mg of caffeine per day (two 5-ounce cups of coffee or four sodas). It affects an individual's alertness, attention, cognitive performance, as well as reduces sleepiness.


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Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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