Navigation Links
Caffeine's effect on the brain's adenosine receptors visualized for the first time
Date:11/1/2012

Reston, Va. (November 1, 2012) Molecular imaging with positron emission tomography (PET) has enabled scientists for the first time to visualize binding sites of caffeine in the living human brain to explore possible positive and negative effects of caffeine consumption. According to research published in the November issue of The Journal of Nuclear Medicine, PET imaging with F-18-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (F-18-CPFPX) shows that repeated intake of caffeinated beverages throughout a day results in up to 50 percent occupancy of the brain's A1 adenosine receptors.

"The effects of caffeine to the human body are generally attributed to the cerebral adenosine receptors. In the human brain the A1 adenosine receptor is the most abundant," said David Elmenhorst, MD, lead author of "Caffeine Occupancy of Human Cerebral A1 Adenosine Receptors: In Vivo Quantification with F-18-CPFPX and PET." "In vitro studies have shown that commonly consumed quantities of caffeine have led to a high A1 adenosine occupancy. Our study aimed to measure the A1 adenosine receptor occupancy with in vivo imaging."

Fifteen male volunteers participated in the study. They abstained from caffeine intake for 36 hours and then underwent a PET scan with F-18-CPFPX. Caffeine was then introduced in short intravenous infusions, increasing in amount. To estimate the occupancy of A1 adenosine receptors by caffeine, the distribution volume at the baseline period of the PET scan was compared with the distribution volume after caffeine administration. Researchers determined that the concentration of the caffeine that displaces 50 percent of the binding of F-18-CPFPX to the A1 adenosine receptor was 13 mg/L, or approximately four to five cups of coffee.

An important finding of the study is that in most regular coffee drinkers about half of the A1 adenosine receptors may be occupied by caffeine. It is likely that this blockage of a substantial amount
'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. New MS drug proves effective where others have failed
2. New study shows effects of prehistoric nocturnal life on mammalian vision
3. Health inequalities could be reduced by more effective health care, says new study
4. Health inequalities could be reduced by more effective healthcare, says new study
5. Genes May Determine Aspirins Effect on Advanced Colon Cancer
6. As painkiller overdoses mount, researchers outline effective approaches to curb epidemic
7. Is magnetic therapy effective for tinnitus?
8. Considerably more patients may benefit from effective antidiabetic drug
9. Surgery more profound effect than anesthesia on brain pathology, cognition in Alzheimers mice
10. NIH-funded analysis estimates effective PrEP dosing
11. Effects of stopping alcohol consumption on subsequent risk of esophageal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Park City, Utah (PRWEB) May 18, 2013 ... new information on insurance agents’ role in ... flexible alternatives to traditional employer sponsored health benefits, ... defined contribution and health reimbursement arrangements ... Department of Health and Human Services (HHS) recently ...
(Date:5/18/2013)... “World Healthcare IT Market: Trends & Forecast (2010 – ... and opportunities in North America, Europe, Asia, & Rest ... 89 market data tables , 20 ... , http://www.marketsandmarkets.com/Market-Reports/healthcare-information-technology-market-136.html , Early buyers will ... IT market is expected to grow from $99.6 billion ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 As ... courts throughout the country, Bernstein Liebhard LLP notes that ... patients often suffer tissue damage before they experience any ... according to Science Daily will appear in the Journal ... recipients underwent MRI screens of their hips. The ...
(Date:5/18/2013)... The “Sleep Apnea Diagnostic & Therapeutic Devices Market ... (ASV), Oral Appliances, Nasal EPAP, Neurostimulation] Global End-user Analysis, ... the major market drivers, restraints, and opportunities in North ... Browse , 147 market data ... 318 pagesand in-depth TOC of “Sleep ...
(Date:5/18/2013)... The Ayurvedic practitioner program will be offered in ... Program is available in Mexico via Live Internet or ... practiced for over 5,000 years. In Ayurvedic medicine ( ... when an individual lives in harmony with their environment, ... aims to heal an individual in all levels (physically, ...
Breaking Medicine News(10 mins):Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 2Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 3Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 4Health News:Healthcare IT Market to reach US$ 162.2 Billion by 2015 at a CAGR of 10.2% - New Report by MarketandMarkets 2Health News:Healthcare IT Market to reach US$ 162.2 Billion by 2015 at a CAGR of 10.2% - New Report by MarketandMarkets 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 2Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 4Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 2Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 3Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2
... , PHILADELPHIA, Dec. 24 Congressman Chaka Fattah ... of comprehensive healthcare reform legislation: , "Senate Democrats deserve ... We have work to do, but I am confident that ... differences. Early in the new year we will be sending ...
... WASHINGTON, Dec. 24 Today,s passage of health care reform in ... one day be a promise we will make to every person ... for you. You will be able to afford coverage and insurance ... Jeff Blum said other steps will include final passage after conference ...
... , AARP Idaho Says Now Is the Time for ... Idaho, Dec. 24 Before the sun was up ... health care costs received a glimmer of hope from Washington, D.C. ... AARP says the Idaho congressional delegation can play a key role ...
... THURSDAY, Dec. 24 (HealthDay News) -- Acetaminophen -- best ... physical pain, but a new study suggests that the ... of rejection. , Researchers assigned 62 healthy college undergraduate ... 1,000 milligrams of acetaminophen daily, while the others took ...
... Dec. 24 "The Senate,s historic vote today helps move ... transformational national long-term services and supports insurance program (CLASS) to ... The Senate bill also includes means by which every American, ... problems. It will stimulate innovation in future models of ...
... , NEW YORK, Dec. 24 ... the Children,s Health Fund , a ... disadvantaged and medically underserved children, today released the following statement on ... Harry Reid: , "First and foremost, we applaud the Senate ...
Cached Medicine News:Health News:A Promise to Keep. Senate Vote is the First Step Toward the Promise of Quality, Affordable Health Care for All 2Health News:Health Care Reform Moves One Step Closer to Bringing Relief to Idaho Families 2Health News:Tylenol May Ease Headaches and Heartaches 2Health News:Tylenol May Ease Headaches and Heartaches 3Health News:Children & Health Reform: Where We Stand 2Health News:Children & Health Reform: Where We Stand 3
(Date:5/17/2013)... DIEGO , May 17, 2013  Sorrento ... that its Fast-Track Advanced Technology Small Business Technology ... Institute of Allergy and Infectious Diseases (NIAID), a ... supporting the development of novel human antibody therapeutics ... aureus or Staph) infections, including methicillin-resistant ...
(Date:5/17/2013)... Ill. , May 17, 2013  Sony Biotechnology ... Sony SP6800 Spectral Analyzer (SP6800).  Sony will be exhibiting ... which will be held at the San ... Diego, California , from May 20 - 22.  ... second analytical system, incorporating commercial audio-visual technologies into new ...
(Date:5/17/2013)... May 17, 2013 /PRNewswire-iReach/ -- The escalation of ... is placing renewed emphasis on alternate delivery technologies. ... a number of factors are converging to create ... and their delivery device partners . These include ... the growing trend toward self-administration for chronic diseases, ...
Breaking Medicine Technology:Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 3Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 4Sony Biotechnology Inc.'s New Technology for Science Provides Researchers Results in Color 2Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 2Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 3
... microbiology testing reveals that one in every six wood pallets that transport food ... of pathogens that spread easily and endanger the nation,s food supply and the ... , Either E. ... in people with lowered immune systems, were found on one in every six ...
... N.J. , June 16 Armed with a clear ... miles away, more than 900 local Roche employees are participating today ... to raise funds to support children infected and affected by HIV/AIDS ... volunteer for the 5K Walk, which takes them through the township ...
Cached Medicine Technology:Consumers at Risk: One in Six Wood Pallets in Los Angeles Discovered With Potentially Deadly Pathogens 2Consumers at Risk: One in Six Wood Pallets in Los Angeles Discovered With Potentially Deadly Pathogens 3Consumers at Risk: One in Six Wood Pallets in Los Angeles Discovered With Potentially Deadly Pathogens 4Roche Holds Seventh Annual Children's Walk 2Roche Holds Seventh Annual Children's Walk 3Roche Holds Seventh Annual Children's Walk 4Roche Holds Seventh Annual Children's Walk 5
... 266 amino acids and is variably N-glycosylated. The ... of between 43 and 56 kDa. Insulin-like growth ... high affinity but do not bind insulin. Of ... at this time, IGFBP-3 has been shown to ...
... is ideal for hospital laboratories, blood bank ... pharmaceutical laboratories. It fully automates the entire ... assays from different manufacturers. The Genesis RMP ... to 600'000 tests, using 4 needles, 8 ...
... assays are designed for ... 2000, a high-throughput, continuous ... IMMULITE 2000 offers testing ... a rapidly expanding menu ...
... Enzyme-linked immunosorbent assays for ... IgG antibodies to extractable nuclear ... (Ro), or SS-B (La)] in ... SS-B (La) antibodies aid in ...
Medicine Products: