Navigation Links
Caffeine Could Stave Off Multiple Sclerosis
Date:6/30/2008

Finding may help scientists develop drug to treat autoimmune disease, researcher says

MONDAY, June 30 (HealthDay News) -- Caffeine just might prevent multiple sclerosis, a new animal study suggests.

Giving mice the equivalent of 6 to 8 cups of coffee a day prevented mice from getting the animal model equivalent of MS, said Dr. Linda Thompson, of the Oklahoma Medical Research Foundation, and a member of the team reporting the finding in this week's issue of the Proceedings of the National Academy of Sciences.

Multiple sclerosis, an autoimmune disease, affects about 400,000 Americans, according to the National Multiple Sclerosis Society. The T-cells from the body's immune system attack the myelin, the fatty sheath that normally protects the nerve fibers in the central nervous system. This, in turn, produces scar tissue and triggers the symptoms of MS, which can include numbness, weakness, lack of muscle coordination and problems with bladder control, speech and vision.

Here's why the coffee warded off MS, Thompson explained: It prevented the molecule adenosine, one of the four building blocks of DNA, from binding to the adenosine receptor at the cellular level. When adenosine cannot bind to receptors at the cellular level, this in turn prevents T-cells from reaching the central nervous system and setting off the events that lead to the animal version of MS.

"From a scientific point of view, the bottom line is, adenosine in this mouse model is needed for the disease-causing T-cells to get into the central nervous system," Thompson said. "That was the big, unexpected finding."

The discovery shows how important the adenosine molecule is in allowing immune cells to infiltrate the central nervous system. In the animals, the T-cells were activated, but they couldn't get into the central nervous system, because the caffeine was bound to the adenosine receptors.

Dr. John Richert, executive vice president of research and clinical programs for the National Multiple Sclerosis Society, said the new finding is "potentially big news many years down the road."

But he cautioned that the research is in the early stages, and the whole process needs to be studied in humans.

Thompson agreed.

"First, we have to learn if adenosine plays the same role in people," she said. "In humans, it is not known if adenosine regulates the entry of T-cells into the central nervous system."

If the same findings bear out in humans, she said, the hope is to develop a drug that would degrade adenosine, prevent it from being formed, or prevent T-cells from getting into the central nervous system. She noted that the discovery holds promise for other autoimmune diseases, including lupus and rheumatoid arthritis.

The challenge, she said, is that adenosine receptors "are everywhere in the body." So, the drug would have to be specific enough to only act on the adenosine receptors that control access of the T-cells to the central nervous system.

Even so, Richert said, "it's a potential therapeutic target that needs to be explored."

More information

To learn more about multiple sclerosis, visit the National Multiple Sclerosis Society.



SOURCES: Linda Thompson, Ph.D., member, Oklahoma Medical Research Foundation, Oklahoma City; John Richert, M.D., executive vice president, research and clinical programs, National Multiple Sclerosis Society, New York, N.Y.; June 30, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Caffeine May Block High Cholesterol Linked to Alzheimers
2. HowToDoThings.com Brews Up New Uses for Coffee That Will Perk You Up in Recognition of Marchs Caffeine Awareness Month
3. Good Morning America! Wake Up to Thinner Legs by Wearing Your Caffeine!
4. Caffeine Could Spell Trouble for Diabetics
5. Cutting caffeine may help control diabetes
6. Caffeine May Lower Ovarian Cancer Risk
7. Ovarian cancer risk not affected by alcohol and smoking, but reduced by caffeine
8. Once Again, Caffeine Linked to Miscarriage
9. New Kaiser Permanente study fortifies caffeines link to miscarriage
10. Kaiser Permanente study shows link between caffeine and miscarriage
11. Bedford Laboratories(TM) Announces the Acquisition of CAFCIT(R) (Caffeine Citrate) Injection CAFCIT(R) (Caffeine Citrate) Oral Solution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caffeine Could Stave Off Multiple Sclerosis
(Date:4/29/2016)... ... 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 out of ... them second place for Tampa’s Best Places to Work. They were ranked in the ... great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. “We work ...
(Date:4/29/2016)... ... 29, 2016 , ... The infertility specialists at HRC Fertility/Orange County (HRC/OC) -- ... A. Potter -- are proud of the recent release of their 2014 in vitro ... SART published the latest verified data for 375 U.S. member clinics. *Preliminary data ...
(Date:4/29/2016)... ... April 29, 2016 , ... Natren, Inc. recently sent representatives ... Petbiotics ™, as they fondly call them. As animal lovers, they were ... their non-profit organizations. Animal rescues across the nation face huge hurdles rescuing animals ...
(Date:4/29/2016)... ... April 29, 2016 , ... HEALTHCAREfirst , the ... services, and Deyta Analytics, recently announced the recipients of the fourth annual Hospice ... as measured from the caregiver’s point of view. The official list of recipients ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... study detailing the company’s use of Microsoft Dynamics GP for one their long-term ... a solution that integrated Dynamics GP with key clinical management systems, and delivered ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016   Zillion Group today ... technology platform, which specializes in live video consultation. ... digital products, Zillion enables companies to realize the ... to take control of their health. ... – including one-to-one, group and webcast scheduled or ...
(Date:4/27/2016)... Oasmia Pharmaceutical AB (NASDAQ: ... new generation of drugs within human and veterinary ... Paclical/Apealea in the Phase III study that included ... cancer. These preliminary results showed non-inferiority between the ... versus Taxol in combination with carboplatin. In fact, ...
(Date:4/26/2016)... , April 26, 2016 Hill-Rom Holdings, Inc. ... a management presentation at the Deutsche Bank 41 st ... 2:50 p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at http://edge.media-server.com/m/p/mr4uxgas . ... hour after conclusion of the live event and accessible at ...
Breaking Medicine Technology: