Navigation Links
CXCR4: A new drug target in lung cancer
Date:4/29/2010

Geneva, 29 April 2010 -- Lung cancer patients whose tumors over-express a cell surface molecule called CXCR4 do significantly worse than those who do not, Canadian researchers have found. Their work, reported at the 2nd European Lung Cancer Conference in Geneva, highlights the exciting possibility that the molecule could soon become a new target for personalized cancer therapy.

CXCR4 is a receptor that is found on the surface of many different cell types in the body. It plays a role in immune system signaling between cells.

In cancer, evidence that CXCR4 is involved in the growth of tumors and their spreading throughout the body (metastasis) has been growing in recent years. For example, researchers have shown in studies in mice that blocking the action of CXCR4 inhibits metastasis. But its precise role in determining outcome and metastatic tendency, especially in lung cancer, is incompletely investigated.

Dr Gwyn Bebb and colleagues from the Tom Baker Cancer Centre in Calgary, Canada set out to explore whether patients whose tumors expressed high levels of the receptor had a worse prognosis than other lung cancer patients.

They studied tumor samples from 103 patients from the Glans-Look lung cancer database who were diagnosed with stage IV non-small-cell lung cancer (cancer which had already spread to other parts of the body) between 2003 and 2006. They found that 10.7% of the tumors over-expressed CXCR4. Those over-expressers had a significantly worse clinical outcome, with a median overall survival of 2.7 months, compared to 6.1 months among low-expressers.

If confirmed in an expanded series of 170 patients from the Glans-Look database, these results will suggest that new strategies to block CXCR4 should be tested in patients whose cancers over-express the molecule, the researchers say.

"I am quite excited about the possibility of using CXCR4 as a therapeutic target, but we need to learn more about its
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sundial Creations Announces the Debut of SheaMoisture Organic Hair Care Exclusively at Target
2. Site Steering Launches Keyword Targeted Small Business Internet Video Advertising Program That Achieves First Page Search Results Within Days
3. Global Summit on International Breast Health Targets Breast Health Improvements in Developing Countries, June 9-11, 2010, in Chicago
4. FDA Targets Safety Problems With Infusion Drug Pumps
5. Gene-Targeted Therapy Might Help Prevent Paralysis
6. Team finds promising new drug target for Alzheimers disease
7. Global Leader Readied For Healthy Aging Boom, Targets Wall Street With New Center In Trump Building
8. New targeted therapy effective in treating advanced prostate cancer
9. Targeting the blood-brain barrier may delay progression of Alzheimers disease
10. Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients
11. New Study on Elder Care Marketing Reveals Fresh Insights in Targeting Aging Population
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Padre Murphy's and Owner Tom Boyle ... Pro Player Health Alliance (PPHA). The PPHA's passion for ... everyone, including NFL greats, treated for obstructive sleep apnea (OSA) ... supporting the cause in the valley. The most recent plans ...
(Date:1/22/2015)... 22, 2015 Blue Cross and Blue Shield ... exemplify what it means to “Live Fearless.” , ... to share their stories about how they or someone they ... others by living in the moment. By telling these types ...
(Date:1/22/2015)... A new white paper by The Beryl ... the long-term care environment as well as provides recommendations ... paper, “The Power of Person-Centeredness in Long-Term Care: A ... the patient, resident and family experience in long-term care ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... 1, Health Carrier Review Act Puts New Resource on the ... Carrier , BOISE, Idaho, Dec. 30 Idaho consumers ... necessary health and medical services will have a new tool ... Health Carrier External Review Act, starting January 1, the Idaho ...
... ... Advantage, a Division of Catalina Lifesciences, Inc. Announces The Promotion of Bret Petkus to ... ... of Catalina Lifesciences, Inc. Announces The Promotion of Bret Petkus to Vice-President of North ...
... , , ALISO VIEJO, Calif., ... ) today announced that the U.S. Food and Drug Administration ... seeking marketing approval for the investigational drug retigabine, a neuronal ... patients with partial-onset seizures. In addition, the European Medicines ...
... , , , ... and online presence specifically created to help ease employment stress ... of "The Happy Hour Effect(TM) Balance Plan" just in time ... http://www.newscom.com/cgi-bin/prnh/20091130/CG16928LOGO ) , This synergistic program consists of ...
... working out to avoid cardiac emergency , WEDNESDAY, Dec. 30 ... brings a surge in colds and flu. But did you ... , Frigid air causes blood vessels to constrict as the ... director of education and outreach at the Ronald O. Perelman ...
... , ... Bariatric Advantage, the market leader in peri-operative nutritional support products ... to over 350 patients in 2009! The program named RECOVER has ... every state in the union participating in this program. The programs ...
Cached Medicine News:Health News:AARP Commends Idaho for Tackling Wrongfully Denied Health Claims 2Health News:Bariatric Advantage, a Division of Catalina Lifesciences, Inc. Announces Appointment of Bret Petkus to Vice-President of North American Sales. 2Health News:FDA Accepts NDA Filing for Retigabine 2Health News:New Year's Resolutions Just Got Easier - Happy Hour Effect LLC to Launch 'The Happy Hour Effect(TM) Balance Plan' in 2010 2Health News:New Year's Resolutions Just Got Easier - Happy Hour Effect LLC to Launch 'The Happy Hour Effect(TM) Balance Plan' in 2010 3Health News:Heart Attacks More Common in Winter 2Health News:Bariatric Advantage Sets a Milestone in "Giving" with RECOVER Program Reaching Hundreds of Needy Weight Loss Surgery Patients in 2009 2
(Date:1/23/2015)... and BOSTON , January 23, 2015 ... discovery and development company, is delighted to announce that the ... awarded to Miles Congreve (Vice President of Chemistry), ... Malcolm Weir (Chief Executive Officer and co-founder) for ...
(Date:1/22/2015)... privately held medical device company, announced today that it ... Corporation (Tokyo Stock Exchange TYO: 8001) to sell its ... in Japan . ViewRay,s technology, the ... MRI-guided radiation therapy system that images and treats cancer ...
(Date:1/22/2015)... UPI ), a medical device company that develops, ... dysfunctions, today reported financial results for the fiscal 2015 ... for the Company,s Urgent ®  PC Neuromodulation System grew ... as compared to $3.9 million in the third quarter ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18
... 2011 Niiki Pharma announced today that it will ... study for its lead product, NKP-1339, at the 2011 ... NKP-1339 is a novel transferrin targeted ruthenium based anti-cancer ... key regulator of mis-folded protein processing. In preclinical studies, ...
... On August 1-3, 2011, coinciding with National Convenient ... the Convenient Care Association will present the 4th annual ... the Gaylord Palms hotel in Orlando, Fla. ... education conference designed specifically for the growing field of ...
Cached Medicine Technology:Novel First-in-Class Anti-Cancer Agent in Development by Niiki Pharma Shows Promising Phase I Results 22011 Retail Clinician Education Congress to Offer Exclusive Accreditation and Networking Opportunities for Retail Healthcare Professionals 2
...
The PICO50 is used for arterial line sampling....
The PICO70 is a self-filling sampler for arterial puncture....
... never handled like this before. ... mind, the Spiroflex catheters unique ... and hydrophilic coating provide outstanding ... in with ease and track ...
Medicine Products: