Navigation Links
CXCR4: A new drug target in lung cancer
Date:4/29/2010

Geneva, 29 April 2010 -- Lung cancer patients whose tumors over-express a cell surface molecule called CXCR4 do significantly worse than those who do not, Canadian researchers have found. Their work, reported at the 2nd European Lung Cancer Conference in Geneva, highlights the exciting possibility that the molecule could soon become a new target for personalized cancer therapy.

CXCR4 is a receptor that is found on the surface of many different cell types in the body. It plays a role in immune system signaling between cells.

In cancer, evidence that CXCR4 is involved in the growth of tumors and their spreading throughout the body (metastasis) has been growing in recent years. For example, researchers have shown in studies in mice that blocking the action of CXCR4 inhibits metastasis. But its precise role in determining outcome and metastatic tendency, especially in lung cancer, is incompletely investigated.

Dr Gwyn Bebb and colleagues from the Tom Baker Cancer Centre in Calgary, Canada set out to explore whether patients whose tumors expressed high levels of the receptor had a worse prognosis than other lung cancer patients.

They studied tumor samples from 103 patients from the Glans-Look lung cancer database who were diagnosed with stage IV non-small-cell lung cancer (cancer which had already spread to other parts of the body) between 2003 and 2006. They found that 10.7% of the tumors over-expressed CXCR4. Those over-expressers had a significantly worse clinical outcome, with a median overall survival of 2.7 months, compared to 6.1 months among low-expressers.

If confirmed in an expanded series of 170 patients from the Glans-Look database, these results will suggest that new strategies to block CXCR4 should be tested in patients whose cancers over-express the molecule, the researchers say.

"I am quite excited about the possibility of using CXCR4 as a therapeutic target, but we need to learn more about its
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sundial Creations Announces the Debut of SheaMoisture Organic Hair Care Exclusively at Target
2. Site Steering Launches Keyword Targeted Small Business Internet Video Advertising Program That Achieves First Page Search Results Within Days
3. Global Summit on International Breast Health Targets Breast Health Improvements in Developing Countries, June 9-11, 2010, in Chicago
4. FDA Targets Safety Problems With Infusion Drug Pumps
5. Gene-Targeted Therapy Might Help Prevent Paralysis
6. Team finds promising new drug target for Alzheimers disease
7. Global Leader Readied For Healthy Aging Boom, Targets Wall Street With New Center In Trump Building
8. New targeted therapy effective in treating advanced prostate cancer
9. Targeting the blood-brain barrier may delay progression of Alzheimers disease
10. Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients
11. New Study on Elder Care Marketing Reveals Fresh Insights in Targeting Aging Population
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... July 06, 2015 , ... MD Now, the leading and ... The newly constructed urgent care center will serve residents and visitors in the Cutler ... being MD Now’s 22nd South Florida location, the new facility will be the fourth ...
(Date:7/6/2015)... ... July 06, 2015 , ... The School ... funds to support a three-year effort to reduce rates of diabetes and cardiovascular ... in partnership with the Morehouse School of Medicine’s Prevention Research Center and the ...
(Date:7/6/2015)... Pompano Beach, Florida (PRWEB) , ... July 06, ... ... call center solutions, announced today that Randstad Technologies selected Aspect Software Unified IP ... provider in the United States, selected Aspect Unified IP as its future call ...
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... Thanks to ... Health and Hospice received the Music & Memory Certification for hospice patients and adult ... power of music not only to patients but also to their families and volunteers. ...
(Date:7/5/2015)... ... , ... City Sports, the Boston-based specialty sporting goods retailer, has renewed their ... triathletes this summer with ethos, the owner and operator of the Boston Triathlon. , ... p.m. at the North End Greenway. The event will help new triathletes prepare for ...
Breaking Medicine News(10 mins):Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 3Health News:Georgia State, Morehouse Partner To Tackle Diabetes, Heart Disease In Atlanta’s Minority Communities 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 2Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 4Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 3
... try to emulate,others, lifestyles, adopt someone,s new fad ... in frustration and failure," writes Larry G.,Patten. "These ... own idea of great,health.", In "Champion Health" ... offering in his Champion Series of,self-improvement books, Patten ...
... see modest tie between displeasure, peripheral artery disease ... Sexual dissatisfaction in postmenopausal women isn,t associated with ... that sexual dysfunction in some men is predictive ... been examined in women. , In this study, ...
... Health Care Quality Act, Would Save Thousands of Lives,Billions ... top companies joined forces Wednesday, April 2, 2008, with ... "Wired for Health Care,Quality Act," a measure to bring ... To view the Multimedia News Release, go to:, ...
... /Xinhua-PRNewswire-FirstCall/ -- China,Nepstar Chain Drugstore Ltd. (NYSE: ... drugstore chain in China based on the number ... been awarded the,title of "Best Drugstore Chain of ... trade publication in the Drugstore industry in China., ...
... The undersigned,organizations from around the state are releasing ... candidates campaigning here now,to draw attention to Pennsylvania,s efforts ... HB 2098 and HB 2005., An Open Letter, ... Senator Obama:, Healthcare has been central to each ...
... /PRNewswire-FirstCall/ - Haemacure Corporation (TSX,: HAE), a ... protein products for commercialization,disclosed today the results ... on,the use of its proprietary lead product ... the formation of post-surgical adhesions., The ...
Cached Medicine News:Health News:'Champion Health': Learn How to Create a Unique, Personalized Health Plan That Works and Keeps Working 2Health News:Postmenopausal Women's Sexual Dissatisfaction Not Linked to Heart Troubles 2Health News:Video: Senators and CEOs Urge Passage of Health IT Bill Now 2Health News:Video: Senators and CEOs Urge Passage of Health IT Bill Now 3Health News:China Nepstar Chain Drugstore Awarded Prestigious Title of '2007 Best Drugstore Chain in China' by China Drugstore Magazine 2Health News:China Nepstar Chain Drugstore Awarded Prestigious Title of '2007 Best Drugstore Chain in China' by China Drugstore Magazine 3Health News:Open Letter to Presidential Candidates on State Health Care Reform 2Health News:Haemacure Discloses Positive Results of a preclinical study of its fibrin sealant in adhesion prevention and opens a new opportunity in a market with a significant unmet medical need 2Health News:Haemacure Discloses Positive Results of a preclinical study of its fibrin sealant in adhesion prevention and opens a new opportunity in a market with a significant unmet medical need 3
(Date:7/6/2015)... July 6, 2015  Student-athletes at community colleges ... from a recently established partnership between ImPACT Applications, ... . The partnership enables member institutions of ... ImPACT ® concussion baseline and post-injury testing ... of community colleges in California ...
(Date:7/6/2015)... July 6, 2015  Array BioPharma Inc. (Nasdaq: ... Executive Officer, Ron Squarer , will present ... New York City.  The public is welcome to ... the Array BioPharma website. Event: Cantor Fitzgerald 2015 Healthcare ... p.m. Eastern Time Webcast: www.arraybiopharma.com About Array BioPharma ...
(Date:7/6/2015)...  EnteroMedics Inc. (NASDAQ: ETRM ), a developer ... treat obesity, metabolic diseases, and other gastrointestinal disorders, today ... its previously announced underwritten public offering of 40,229,886 units ... unit. Canaccord Genuity was acting as ... as co-manager for the offering. The offering ...
Breaking Medicine Technology:California Community College Athletic Departments to Benefit from ImPACT Concussion Baseline Testing Offered by Student Insurance 2California Community College Athletic Departments to Benefit from ImPACT Concussion Baseline Testing Offered by Student Insurance 3EnteroMedics Inc. Announces Termination of Public Offering of Common Stock and Warrants 2
... CHENGDU, China , June 28 ... biopharmaceutical company that specializes,in patented biopharmaceutical, modernized traditional Chinese ... product portfolio at,the 45th 2010 National New Special Drugs ... 8th , till July 10th . Tianyin,s portfolio ...
... SAN DIEGO , June 28 ADVENTRX Pharmaceuticals, ... added to the Russell Microcap® Index on June 25, 2010 , ... , , ... available only to companies listed on a national exchange, is consistent with ...
Cached Medicine Technology:Tianyin Promotes its Flagship Product Portfolio at the 45th 2010 National New Special Drugs Trade Fair in July at Beijing 2Tianyin Promotes its Flagship Product Portfolio at the 45th 2010 National New Special Drugs Trade Fair in July at Beijing 3ADVENTRX Added to Russell Microcap Index 2
... The pharmaceutical subset of the ... 21 of the Code of ... and final rules published in ... updated regularly as released by ...
... measuring principle - Pupil Zone Imaging Method ... offers high accuracy and reliability in refraction ... measurement (3.3 mm) using a mire ring, ... 4 points, both of which offer reliable ...
The combination of new measuring principle - Pupil Zone Imaging Method - and unique technology - SLD - offers high accuracy and reliability in refraction measurement....
... The ISI Free-Standing upper extremity table ... and in-office procedures. This table features ... and an extra-durable, hour-glass shaped Lexan ... stable -- this table is our ...
Medicine Products: